|
119
|
| 5054 |
XBP1
|
|
affects_activity of
|
autophagy
|
|
|
19762508
|
Amyotrophic lateral sclerosis
|
|
123
|
| 429 |
XBP1
|
|
affects_activity of
|
autophagy
|
|
|
19762508
|
Amyotrophic lateral sclerosis
|
|
124
|
| 430 |
Amyotrophic lateral sclerosis
|
|
increases_activity of
|
autophagy
|
|
|
19762508
|
Amyotrophic lateral sclerosis
|
|
156
|
| 597 |
PINK1
|
|
decreases_activity of
|
autophagy
|
|
| 11733 |
O2-
|
|
increases_activity of
|
autophagy
|
|
|
19279012
|
Parkinson disease
|
|
215
|
| 850 |
autophagy
|
|
decreases_quantity of
|
MEF2D
|
|
| 13596 |
SNCA-p.A53T
|
|
decreases_activity of
|
autophagy
|
thus increasing the amount of MEF2D
|
|
19119233
|
Parkinson disease
|
|
227
|
| 923 |
autophagy
|
|
decreases_quantity of
|
SNCA
|
|
|
18566453
|
Parkinson disease
|
|
228
|
| 10397 |
autophagy
|
|
decreases_quantity of
|
SNCA
|
|
|
18566453
|
Parkinson disease
|
|
338
|
| 3026 |
autophagy
|
NOT |
decreases_quantity of
|
LRRK2
|
|
|
18367605
|
Parkinson disease
|
|
453
|
| 2008 |
LRRK2
|
|
affects_activity of
|
autophagy
|
|
| 2009 |
LRRK2-p.R1441C
|
|
decreases_activity of
|
autophagy
|
|
|
19770575
|
Neurological
|
|
460
|
| 2074 |
SQSTM1
|
|
affects_activity of
|
autophagy
|
|
|
19765191
|
Amyotrophic lateral sclerosis
|
|
463
|
| 2169 |
Phosphatidylinositol 3,5-bisphosphate
|
|
affects_activity of
|
autophagy
|
|
|
19793721
|
Amyotrophic lateral sclerosis
Charcot-Marie-Tooth disease, type 4J
|
|
470
|
| 2172 |
LRRK2
|
|
affects_activity of
|
autophagy
|
|
|
19640926
|
Parkinson disease
|
|
471
|
| 2165 |
Phosphatidylinositol 3,5-bisphosphate
|
|
affects_activity of
|
autophagy
|
|
|
19793721
|
Amyotrophic lateral sclerosis
Charcot-Marie-Tooth disease, type 4J
|
|
473
|
| 2184 |
MAP1LC3A
|
|
affects_activity of
|
autophagy
|
|
| 2201 |
autophagy
|
|
decreases_activity of
|
neuron projection development
|
|
|
18182054
|
Parkinson disease
|
|
474
|
| 2233 |
Lithium
|
|
increases_activity of
|
autophagy
|
|
|
18250315
|
Amyotrophic lateral sclerosis
|
|
475
|
| 2208 |
MAP1LC3A
|
|
affects_activity of
|
autophagy
|
|
| 2210 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
|
|
increases_activity of
|
macroautophagy
|
|
| 2211 |
BECN1
|
|
increases_activity of
|
autophagy
|
|
| 2213 |
U0126
|
|
decreases_activity of
|
autophagy
|
if autophagy has been induced by MPP treatment
|
|
17200184
|
Parkinson disease
|
|
477
|
| 2239 |
Ammonium chloride
|
|
decreases_activity of
|
autophagy
|
|
|
15333840
|
Parkinson disease
|
|
479
|
| 2249 |
response to starvation
|
|
increases_activity of
|
macroautophagy
|
|
| 2250 |
response to starvation
|
|
increases_activity of
|
autophagy
|
|
| 2257 |
autophagy
|
|
decreases_quantity of
|
SNCA
|
|
| 2266 |
SNCA-p.A30P
|
|
decreases_activity of
|
autophagy
|
|
| 2267 |
SNCA-p.A53T
|
|
decreases_activity of
|
autophagy
|
|
| 2268 |
autophagy
|
NOT |
decreases_quantity of
|
SNCA-p.A30P
|
|
| 2269 |
autophagy
|
NOT |
decreases_quantity of
|
SNCA-p.A53T
|
|
|
15333840
|
Parkinson disease
|
|
489
|
| 2313 |
PINK1
|
|
increases_activity of
|
autophagy
|
|
| 2314 |
PINK1-p.W437X
|
NOT |
increases_activity of
|
autophagy
|
|
| 2348 |
PINK1-p.G309D
|
|
increases_activity of
|
autophagy
|
|
|
20057503
|
Parkinson disease
|
|
504
|
| 2498 |
alpha-synuclein inclusion body
|
|
decreases_activity of
|
autophagy
|
|
| 2499 |
SNCA
|
|
decreases_activity of
|
autophagy
|
if SNCA is overexpressed
|
| 2504 |
BECN1
|
|
increases_activity of
|
autophagy
|
|
| 2506 |
Rapamycin
|
|
increases_activity of
|
autophagy
|
|
| 2507 |
autophagy
|
|
decreases_quantity of
|
alpha-synuclein inclusion body
|
|
|
19864570
|
Dementia, Lewy body
Parkinson disease
|
|
510
|
| 2536 |
BECN1
|
|
increases_activity of
|
autophagy
|
|
|
19864570
|
Dementia, Lewy body
Parkinson disease
Synucleinopathy
|
|
515
|
| 2546 |
Rapamycin
|
|
increases_activity of
|
autophagy
|
|
| 2552 |
autophagy
|
|
decreases_activity of
|
neuron death
|
|
|
19682553
|
Neurological
|
|
850
|
| 5061 |
XBP1
|
|
affects_activity of
|
autophagy
|
in female mice
|
|
19762508
|
Amyotrophic lateral sclerosis
|
|
1,089
|
| 6907 |
Lithium
|
|
increases_activity of
|
autophagy
|
|
|
18250315
|
Amyotrophic lateral sclerosis
|
|
1,101
|
| 6996 |
EHNA
|
|
decreases_activity of
|
autophagy
|
|
| 6997 |
Dynein complex
|
|
increases_activity of
|
autophagy
|
|
|
15980862
|
Amyotrophic lateral sclerosis
Huntington disease
|
|
1,104
|
| 7002 |
DYNC1H1-mut
|
|
decreases_activity of
|
autophagy
|
|
|
15980862
|
Amyotrophic lateral sclerosis
Huntington disease
|
|
1,363
|
| 9330 |
LAMP2
|
|
affects_activity of
|
autophagy
|
|
|
18550537
|
Parkinson disease
|
|
1,365
|
| 9331 |
autophagy
|
|
decreases_quantity of
|
UCHL1
|
|
| 9338 |
UCHL1-p.I93M
|
|
decreases_activity of
|
autophagy
|
probably due to stronger binding to LAMP2
|
| 9339 |
autophagy
|
|
decreases_quantity of
|
SNCA
|
|
|
18550537
|
Parkinson disease
|
|
1,387
|
| 9567 |
UBQLN1
|
|
affects_activity of
|
autophagy
|
|
|
19112176
|
Amyotrophic lateral sclerosis
|
|
1,429
|
| 9993 |
SNCA
|
|
decreases_activity of
|
macroautophagy
|
if SNCA is overexpressed
|
| 9995 |
RAB1A
|
|
increases_activity of
|
macroautophagy
|
independently of the secretory pathway
|
| 10000 |
ATG9
|
|
affects_activity of
|
macroautophagy
|
|
|
20855506
|
Parkinson disease
|
CIDeRplus