|
158
|
| 13610 |
MAPK3
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
|
17906618
|
Parkinson disease
|
|
467
|
| 2132 |
LRRK2
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
| 2133 |
LRRK2-p.Y1699C
|
NOT |
increases_activity of
|
ERK1 and ERK2 cascade
|
|
| 4409 |
ERK1 and ERK2 cascade
|
|
decreases_activity of
|
response to oxidative stress
|
if oxidative stress has been induced by H2O2
|
|
18675914
|
Parkinson disease
|
|
685
|
| 3736 |
PD98059
|
|
decreases_activity of
|
ERK1 and ERK2 cascade
|
via inhibiting MEK1
|
|
19769964
|
Parkinson disease
|
|
921
|
| 128940 |
KDR
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
|
18178312
|
Amyotrophic lateral sclerosis
|
|
1,002
|
| 6239 |
MAP2K1
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
| 6245 |
ERK1 and ERK2 cascade
|
|
increases_activity of
|
NFE2L2
|
|
| 6253 |
Luteolin
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
|
17982879
|
Parkinson disease
|
|
1,070
|
| 6750 |
ERK1 and ERK2 cascade
|
|
increases_expression of
|
PARK7
|
|
| 6751 |
Dopamine
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
|
18974921
|
Parkinson disease
|
|
1,078
|
| 6809 |
LRRK2
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
| 6817 |
ERK1 and ERK2 cascade
|
|
increases_expression of
|
SNCA
|
|
|
20074637
|
Parkinson disease
|
|
1,145
|
| 7482 |
SNCA
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
|
17166628
|
Parkinson disease
|
|
1,211
|
| 8151 |
SNCA
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
via ERK1/ERK2 phosphorylation
|
|
17012252
|
Parkinson disease
|
|
1,236
|
| 8313 |
alpha-synuclein inclusion body
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
in microglia
|
| 8316 |
ERK1 and ERK2 cascade
|
|
increases_activity of
|
inflammatory response
|
in microglia
|
|
20074453
|
Parkinson disease
|
|
1,649
|
| 12100 |
ERK1 and ERK2 cascade
|
|
increases_quantity of
|
PAX6
|
|
|
17277739
|
Neurological
|
|
1,659
|
| 12242 |
Tg2576 mouse
|
|
affects_activity of
|
ERK1 and ERK2 cascade
|
|
| 12262 |
MAPK1
|
|
affects_activity of
|
ERK1 and ERK2 cascade
|
|
| 12264 |
MAPK3
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
|
12196559
|
Alzheimer disease
|
|
1,937
|
| 15005 |
MPL
|
|
affects_activity of
|
ERK1 and ERK2 cascade
|
|
|
20711984
|
Hematological
|
|
2,142
|
| 17868 |
Atenolol
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
|
20818929
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,110
|
| 28562 |
LEP
|
|
affects_activity of
|
ERK1 and ERK2 cascade
|
|
|
18790715
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,613
|
| 34082 |
Taurocholate
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
in liver
|
|
20305288
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,762
|
| 36622 |
Homocysteine thiolactone
|
|
decreases_activity of
|
ERK1 and ERK2 cascade
|
|
| 36630 |
Glutathione
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
after homocysteine thiolactone incubation
|
|
15691882
|
Diabetes mellitus, type II
Insulin resistance
|
|
4,322
|
| 44282 |
AGPAT2
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
|
22872237
|
Metabolic
Lipodystrophy
|
|
5,040
|
| 65978 |
GRIN2B
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
|
14622581
|
Neurological
|
|
5,795
|
| 54694 |
ERK1 and ERK2 cascade
|
|
increases_phosphorylation of
|
PDX1
|
|
|
17659992
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,948
|
| 56074 |
AGGF1
|
|
decreases_activity of
|
ERK1 and ERK2 cascade
|
|
|
23628701
|
Atherosclerosis
|
|
6,224
|
| 58250 |
Ouabain
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
| 58253 |
ERK1 and ERK2 cascade
|
|
affects_quantity of
|
CLDN3
|
|
| 58254 |
ERK1 and ERK2 cascade
|
|
affects_activity of
|
Tight junction complex
|
|
| 58256 |
ERK1 and ERK2 cascade
|
|
increases_activity of
|
cell population proliferation
|
|
|
24186357
|
Cancer
|
|
6,335
|
| 59432 |
ARF1
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
|
22025613
|
Breast cancer
Diabetes mellitus, type II
Insulin resistance
|
|
6,363
|
| 59919 |
cholesterol import
|
|
affects_activity of
|
ERK1 and ERK2 cascade
|
|
| 59927 |
epidermal growth factor receptor signaling pathway
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
| 59928 |
ERK1 and ERK2 cascade
|
|
increases_activity of
|
PKM2
|
|
|
26164081
|
Diabetes mellitus, type II
Pancreatic cancer
Insulin resistance
|
|
6,606
|
| 63640 |
FGFR4-KLB complex
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
in liver
|
| 63643 |
ERK1 and ERK2 cascade
|
|
decreases_expression of
|
CYP7A1
|
in liver
|
|
26579434
|
Colorectal cancer
Diabetes mellitus, type II
Insulin resistance
|
|
6,726
|
| 65024 |
USP39
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
in human melanoma A375 and M14 cell lines
|
|
27456357
|
Cancer
Metabolic
|
|
7,032
|
| 68978 |
INVS
|
|
affects_activity of
|
ERK1 and ERK2 cascade
|
|
|
|
Senior-Loken syndrome
Ciliopathy
|
|
7,279
|
| 71480 |
PLPP3
|
|
decreases_activity of
|
ERK1 and ERK2 cascade
|
|
| 71483 |
Lysophosphatidic acid
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
|
23104851
|
Coronary artery disease
|
|
7,406
|
| 72666 |
Lysophosphatidylcholine
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
|
17105874
|
Cardiovascular disease
|
|
7,526
|
| 74239 |
FGFR4
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
|
|
25073467
|
Gastrointestinal
Metabolic
|
CIDeRplus