CIDeRplusGeneral Information:
| Id: | 999 |
| Diseases: |
Alzheimer disease
- [OMIM]
|
| Mus musculus | |
| APPswe/PS1d9 transgenic mouse | |
| article | |
| Reference: | Garcia-Alloza M et al.(2006) Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model J. Neuropathol. Exp. Neurol. 65: 1082-1089 [PMID: 17086105] |
Interaction Information:
| Comment | Generation of reactive oxygen species occurs by amyloid deposits (senile plaques). |
|
Formal Description Interaction-ID: 6204 |
phenotype increases_quantity of drug/chemical compound Reactive oxygen species |
| Comment | Both Ginkgo biloba extract and vitamin E reduced the oxidative stress resulting from senile plaques in vivo. |
|
Formal Description Interaction-ID: 6205 |
|
| Comment | Both Ginkgo biloba extract and vitamin E lead to a progressive reversal of the structural changes in dystrophic neurites associated with senile plaques. |
|
Formal Description Interaction-ID: 6206 |
drug/chemical compound Ginkgo biloba decreases_activity of cellular component dystrophic neurite |
| Drugbank entries | Show/Hide entries for Ginkgo biloba |
| Comment | Both Ginkgo biloba extract and vitamin E lead to a progressive reversal of the structural changes in dystrophic neurites associated with senile plaques. |
|
Formal Description Interaction-ID: 6207 |
|
| Comment | Both Ginkgo biloba extract and vitamin E reduced the oxidative stress resulting from senile plaques in vivo. |
|
Formal Description Interaction-ID: 6208 |
|
| Drugbank entries | Show/Hide entries for Ginkgo biloba |
| Comment | Both Ginkgo biloba extract and vitamin E reduced the oxidative stress resulting from senile plaques in vivo. |
|
Formal Description Interaction-ID: 6209 |
|