General Information:

Id: 989
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Niso-Santano M et al.(2010) Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis Free Radic. Biol. Med. 48: 1370-1381 [PMID: 20202476]

Interaction Information:

Comment Paraquat is a well known complex I inhibitor releasing reactive oxygen species (ROS) and dopaminergic toxicants. It is widely used to model PD.
Formal Description
Interaction-ID: 6143

drug/chemical compound

Paraquat

decreases_activity of

complex/PPI

Mitochondrial respiratory chain complex I

Comment Paraquat is a well known complex I inhibitor releasing reactive oxygen species (ROS) and dopaminergic toxicants. It is widely used to model PD.
Formal Description
Interaction-ID: 6145

drug/chemical compound

Paraquat

increases_quantity of

drug/chemical compound

Reactive oxygen species

Comment Paraquat is a well known complex I inhibitor releasing reactive oxygen species (ROS) and dopaminergic toxicants. It is widely used to model PD.
Formal Description
Interaction-ID: 6154

drug/chemical compound

Paraquat

increases_activity of

process

neuron death

Comment Inhibition of p38 and JNK by addition of SB203580 or SP600125, protects against paraquat-induced apoptotic cell death.
Formal Description
Interaction-ID: 6161

gene/protein

p38 MAPK

increases_activity of

process

neuron death

induced by Paraquat
Comment Inhibition of p38 and JNK by addition of SB203580 or SP600125, protects against paraquat-induced apoptotic cell death.
Formal Description
Interaction-ID: 6162

gene/protein

MAPK8

increases_activity of

process

neuron death

induced by Paraquat
Drugbank entries Show/Hide entries for MAPK8
Comment PQ promoted ASK1 activation by dephosphorylation at Ser83 and Ser967 and phosphorylation at Thr845 residues.
Formal Description
Interaction-ID: 6163

drug/chemical compound

Paraquat

increases_activity of

gene/protein

MAP3K5

via modulation of the various phosphorylated forms of ASK1
Comment PQ-induced activation of ASK1 was almost completely abolished by preincubation with the free radical scavenger Vit E, indicating that activation of this stress kinase by PQ is due to its redox altering activity.
Formal Description
Interaction-ID: 6164

drug/chemical compound

alpha-Tocopherol

decreases_activity of

gene/protein

MAP3K5

if activity of ASK1 has been induced by PQ
Comment Paraquat activates ASK1 downstream signaling pathways.
Formal Description
Interaction-ID: 6165

drug/chemical compound

Paraquat

increases_activity of

process

stress-activated MAPK cascade

Comment Overexpression of ASK1 accelerates paraquat-induced apoptotic cell death via JNK and p38 activation in an oxidative-stress-dependent manner.
Formal Description
Interaction-ID: 6166

gene/protein

MAP3K5

increases_activity of

process

neuron apoptotic process

after PQ treatment
Comment TRX binds and inhibits ASK1.
Formal Description
Interaction-ID: 6167

gene/protein

TXN

interacts (colocalizes) with

gene/protein

MAP3K5

Comment TRX gene expression is regulated by the transcription factor NRF2.
Formal Description
Interaction-ID: 6168

gene/protein

NFE2L2

increases_expression of

gene/protein

TXN

Comment Trx levels were considerably increased in the presence of SFN in cells treated with PQ, correlating with an inhibition of ASK1 activation.
Formal Description
Interaction-ID: 6169

drug/chemical compound

Sulforaphane

increases_quantity of

gene/protein

TXN

after PQ treatment
Comment Pretreatment with SFN resulted in a significant decrease in apoptosis in the presence of PQ.
Formal Description
Interaction-ID: 6170

drug/chemical compound

Sulforaphane

decreases_activity of

process

neuron apoptotic process

after PQ treatment
Comment TRX binds and inhibits ASK1.
Formal Description
Interaction-ID: 6213

gene/protein

TXN

decreases_activity of

gene/protein

MAP3K5