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Field	Query

	Field	Term

General Information:

Id:	9,836
Diseases:	Cardiomyopathy, dilated
Organism:	Mammalia
Publication type:	article
Reference:	Rafiq K et al.(2014) c-Cbl inhibition improves cardiac function and survival in response to myocardial ischemia Circulation 129: 2031-2043 [PMID: 24583314]

Interaction Information:

Comment	Cardiac explants from human donors were assessed for c-Cbl expression using Western blot and immunohistochemistry. Figure 1C shows increased c-Cbl immunostaining in both ischemic (ICM) and dilated cardiomyopathies (DCM) compared to non-failing hearts.
Formal Description Interaction-ID: 103633	phenotype cardiac ischemia increases_expression of gene/protein CBL in human patients

Comment	Cardiac explants from human donors were assessed for c-Cbl expression using Western blot and immunohistochemistry. Figure 1C shows increased c-Cbl immunostaining in both ischemic (ICM) and dilated cardiomyopathies (DCM) compared to non-failing hearts.
Formal Description Interaction-ID: 103634	disease Cardiomyopathy, dilated increases_expression of gene/protein CBL in human patients

Comment	c-Cbl protein was highly expressed in fetal hearts at 12.5 day and this expression decreased gradually throughout fetal life (-17 ¬Ī3% at E19.5 compared to E12.5).
Formal Description Interaction-ID: 103635	process embryo development decreases_dissociation of gene/protein CBL in hearts; of healthy mouse models

Comment	After birth, c-Cbl expression decreased significantly at 3d and 7d post-natal (-30 ¬Ī2% at 1d, -37 ¬Ī2% at 3d, and -46 ¬Ī3% at 7d compared to E12.5) and reached low but detectable levels in adult hearts (-80 ¬Ī5% compared to E12.5).
Formal Description Interaction-ID: 103636	process parturition decreases_expression of gene/protein CBL in hearts; of healthy mouse models after birth

Comment	After birth, c-Cbl expression decreased significantly at 3d and 7d post-natal (-30 ¬Ī2% at 1d, -37 ¬Ī2% at 3d, and -46 ¬Ī3% at 7d compared to E12.5) and reached low but detectable levels in adult hearts (-80 ¬Ī5% compared to E12.5).
Formal Description Interaction-ID: 103637	process aging decreases_expression of gene/protein CBL in hearts; of healthy mouse models after birth

Comment	Myocytes challenged with hypertrophic agonists norepinephrine (primarily an alpha-adrenergic receptor agonist), isoproterenol (a non-selective alpha-adrenergic receptor agonist), thrombin, or TNF-alpha for 48 hours showed an increase in c-Cbl accumulation compared to controls in neonatal rat cardiomyocytes.
Formal Description Interaction-ID: 103638	drug/chemical compound Noradrenaline increases_quantity of gene/protein CBL in cardiomyocytes; of neonatal rats

Comment	Myocytes challenged with hypertrophic agonists norepinephrine (primarily an alpha-adrenergic receptor agonist), isoproterenol (a non-selective alpha-adrenergic receptor agonist), thrombin, or TNF-alpha for 48 hours showed an increase in c-Cbl accumulation compared to controls in neonatal rat cardiomyocytes.
Formal Description Interaction-ID: 103639	complex/PPI Thrombin increases_quantity of gene/protein CBL in cardiomyocytes; of neonatal rats

Comment	Myocytes challenged with hypertrophic agonists norepinephrine (primarily an alpha-adrenergic receptor agonist), isoproterenol (a non-selective alpha-adrenergic receptor agonist), thrombin, or TNF-alpha for 48 hours showed an increase in c-Cbl accumulation compared to controls in neonatal rat cardiomyocytes.
Formal Description Interaction-ID: 103640	gene/protein TNF increases_quantity of gene/protein CBL in cardiomyocytes; of neonatal rats
Drugbank entries	Show/Hide entries for TNF
Drugbank DB00005	Etanercept antibody TNF
Drugbank DB00051	Adalimumab antibody TNF
Drugbank DB00065	Infliximab inhibitor TNF
Drugbank DB00608	Chloroquine not specified TNF
Drugbank DB01041	Thalidomide inhibitor TNF
Drugbank DB01296	Glucosamine not specified TNF
Drugbank DB01407	Clenbuterol other/unknown TNF
Drugbank DB01411	Pranlukast other/unknown TNF
Drugbank DB01427	Amrinone inhibitor TNF
Drugbank DB00051	Adalimumab antibody TNF
Drugbank DB00065	Infliximab inhibitor TNF
Drugbank DB01427	Amrinone inhibitor TNF

Comment	Myocytes challenged with hypertrophic agonists norepinephrine (primarily an alpha-adrenergic receptor agonist), isoproterenol (a non-selective alpha-adrenergic receptor agonist), thrombin, or TNF-alpha for 48 hours showed an increase in c-Cbl accumulation compared to controls in neonatal rat cardiomyocytes.
Formal Description Interaction-ID: 103641	drug/chemical compound Isoproterenol increases_quantity of gene/protein CBL in cardiomyocytes; of neonatal rats
Drugbank entries	Show/Hide entries for Isoproterenol
Drugbank DB01064	Isoproterenol agonist ADRB1
Drugbank DB01064	Isoproterenol agonist ADRB2
Drugbank DB01064	Isoproterenol agonist PIK3R1
Drugbank DB01064	Isoproterenol agonist ADRB3
Drugbank DB01064	Isoproterenol inducer MAPK1
Drugbank DB01064	Isoproterenol agonist PIK3R2
Drugbank DB01064	Isoproterenol agonist PIK3R3

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