CIDeRplusGeneral Information:
| Id: | 9,689 |
| Diseases: |
Anxiety disorders
Major depressive disorder - [OMIM] Metabolic |
| Mammalia | |
| review | |
| Reference: | Higuchi Y et al.(2017) Regulatory Pathways of Monoamine Oxidase A during Social Stress Front Neurosci 11: 604 [PMID: 29163009] |
Interaction Information:
| Comment | An association between SIRT1 single nucleotide polymorphism and several psychiatric disorders, including social phobia (rs12778366), anxiety disorder (rs10997870), and panic disorder (rs12778366 and rs10997870) has been reported which indicates that SIRT1 is associated with mental disorders in humans. |
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Formal Description Interaction-ID: 102224 |
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| Comment | An association between SIRT1 SNP (rs10997875) and MDD in Japanese subjects has also been reported. |
|
Formal Description Interaction-ID: 102242 |
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| Comment | Patients with MDD show significantly lower SIRT1 mRNA levels in peripheral white blood cells in depressive states whereas this reduction in SIRT1 mRNA is not observed in MDD patients in remissive state, implying that SIRT1 in peripheral white blood cells could be utilized as a potential state-dependent biomarker for MDD. |
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Formal Description Interaction-ID: 102243 |
disease decreases_expression of gene/protein |
| Comment | In animal models, chronic social defeat stress increases SIRT1 mRNA and protein levels in the nucleus accumbens. |
|
Formal Description Interaction-ID: 102244 |
environment chronic social defeat stress increases_expression of gene/protein |
| Comment | Brain-specific SIRT1 knockout mice show lower MAOA gene expression levels, higher 5-HT levels, lower 5-HIAA levels in the brain and less susceptibility to social defeat stress, compared to wild-type mice. |
|
Formal Description Interaction-ID: 102245 |
organism model SIRT1 KO mouse decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for MAOA |
| Comment | SIRT1 overexpression mice show higher MAO-A gene expression levels, lower 5-HT levels, and higher 5-HIAA levels in the brain, compared to wild-type mice. |
|
Formal Description Interaction-ID: 102246 |
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| Drugbank entries | Show/Hide entries for MAOA |
| Comment | NHLH2 deacetylated on lysine 49 by SIRT1 can activate the transcription of MAO-A by binding to NHLH2-binding sites in the MAO-A promoter region. |
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Formal Description Interaction-ID: 102249 |
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| Drugbank entries | Show/Hide entries for MAOA |
| Comment | FOXO1 is involved in the valproate-induced activation of MAO-A gene expression, catalytic activity, and promoter activity. FOXO1 represses the transcription of MAO-A by directly binding to a FOXO1-binding site of the MAO-A promoter. |
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Formal Description Interaction-ID: 102250 |
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| Drugbank entries | Show/Hide entries for Valproic acid or MAOA |
| Comment | SIRT1 deacetylates the FOXO1 and represses its activity in HeLa cells. |
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Formal Description Interaction-ID: 102251 |
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| Comment | NHLH2 acts as an activator of 5-HT metabolism, while FOXO1 acts as a repressor in SIRT1 signaling. |
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Formal Description Interaction-ID: 102252 |
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| Comment | A factor changed by social stress in animal models or depression in human is SERT/SLC6A4 (decreased in mouse and human). |
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Formal Description Interaction-ID: 102253 |
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| Drugbank entries | Show/Hide entries for SLC6A4 |
| Comment | A factor changed by social stress in animal models or depression in human is MAOA (decreased in mouse and increased in human and rat). |
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Formal Description Interaction-ID: 102254 |
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| Drugbank entries | Show/Hide entries for MAOA |
| Comment | A factor changed by social stress in animal models is SIRT1 (increased in mouse). |
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Formal Description Interaction-ID: 102255 |
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| Comment | A factor changed by social stress in animal models is serotonin/5-HT (increased in mouse, decreased in rat). |
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Formal Description Interaction-ID: 102256 |
process increases_quantity of drug/chemical compound |
| Comment | A factor changed by social stress in animal models or depression in human is KLF11 (increased in human, mouse, rat). |
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Formal Description Interaction-ID: 102257 |
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| Comment | A factor changed by depression in human is R1 (decreased in human). |
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Formal Description Interaction-ID: 102258 |
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| Comment | A factor changed by social stress in animal models is CRH (decreased in rat, increased in mouse). |
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Formal Description Interaction-ID: 102259 |
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| Drugbank entries | Show/Hide entries for CRH |
| Comment | A factor changed by social stress in animal models is CRH-R1 (increased in rat). |
|
Formal Description Interaction-ID: 102260 |
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| Comment | Corticosterone treatment decreases 5-HT1A receptor in the hippocampus but increases the 5-HT2 receptor in the frontal cortex in rats. |
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Formal Description Interaction-ID: 102261 |
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| Drugbank entries | Show/Hide entries for HTR1A |
| Comment | KLF11 activates the transcription of MAO-A by binding to SP1 binding sites. |
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Formal Description Interaction-ID: 102262 |
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| Drugbank entries | Show/Hide entries for MAOA |
| Comment | NHLH2 deacetylated by SIRT1 acts as a transcriptional activator of MAO-A. |
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Formal Description Interaction-ID: 102263 |
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| Drugbank entries | Show/Hide entries for MAOA |
| Comment | FOXO1 deacetylated by SIRT1 functions as a transcriptional suppressor of MAO-A. |
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Formal Description Interaction-ID: 102264 |
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| Comment | R1 represses the transcription of MAO-A gene by binding to SP1 binding sites. |
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Formal Description Interaction-ID: 102265 |
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| Drugbank entries | Show/Hide entries for MAOA |
| Comment | RINES/RNF80 promotes the ubiquitination and degradation of MAO-A protein. |
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Formal Description Interaction-ID: 102266 |
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| Drugbank entries | Show/Hide entries for MAOA |
| Comment | RINES/RNF80 promotes the ubiquitination and degradation of MAO-A protein. |
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Formal Description Interaction-ID: 102267 |
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| Drugbank entries | Show/Hide entries for MAOA |
| Comment | R1 represses the transcription of MAO-A gene by binding to SP1 binding sites. |
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Formal Description Interaction-ID: 102268 |
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| Drugbank entries | Show/Hide entries for MAOA |
| Comment | NHLH2 deacetylated by SIRT1 acts as a transcriptional activator of MAO-A. |
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Formal Description Interaction-ID: 102269 |
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| Comment | FOXO1 deacetylated by SIRT1 functions as a transcriptional suppressor of MAO-A. |
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Formal Description Interaction-ID: 102270 |
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| Drugbank entries | Show/Hide entries for MAOA |
| Comment | Corticosterone treatment decreases 5-HT1A receptor in the hippocampus but increases the 5-HT2 receptor in the frontal cortex in rats. |
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Formal Description Interaction-ID: 102271 |
drug/chemical compound increases_quantity of gene/protein HTR2 |
| Comment | 5-HT signals influence the HPA-axis through the regulation of CRH levels in the brain. Intracerebroventricular injection of 5-HT induces the increase in CRH gene expression in the hypothalamic paraventricular nucleus of rats, which is abolished by pretreatment with a selective 5-HT1A receptor antagonist or a selective 5-HT3 receptor antagonist, rather than a selective 5-HT2A/2C receptor antagonist. |
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Formal Description Interaction-ID: 102272 |
drug/chemical compound affects_activity of process HPA axis |
| Comment | CRH mRNA expression is increased by the intracerebroventricular administration of 5-HTP (precursor of 5-HT) and fluoxetine (selective serotonin reuptake inhibitor) as well as the intracerebroventricular administration of specific 5-HT1A, 5-HT1B, 5-HT2A, or 5-HT2C receptor agonist but not by specific 5-HT3 receptor agonist. |
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Formal Description Interaction-ID: 102273 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for CRH |
| Comment | A factor changed by social stress in animal models is CRH (decreased in rat, increased in mouse). |
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Formal Description Interaction-ID: 102274 |
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| Drugbank entries | Show/Hide entries for CRH |
| Comment | A factor changed by social stress in animal models or depression in human is KLF11 (increased in human, mouse, rat). |
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Formal Description Interaction-ID: 102275 |
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| Comment | A factor changed by social stress in animal models is serotonin/5-HT (increased in mouse, decreased in rat). |
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Formal Description Interaction-ID: 102276 |
process decreases_quantity of drug/chemical compound |
| Comment | A factor changed by social stress in animal models or depression in human is MAOA (decreased in mouse and increased in human and rat). |
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Formal Description Interaction-ID: 102277 |
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| Drugbank entries | Show/Hide entries for MAOA |
| Comment | A factor changed by social stress in animal models or depression in human is MAOA (decreased in mouse and increased in human and rat). |
|
Formal Description Interaction-ID: 102278 |
|
| Drugbank entries | Show/Hide entries for MAOA |
| Comment | A factor changed by social stress in animal models or depression in human is SERT/SLC6A4 (decreased in mouse and human). |
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Formal Description Interaction-ID: 102279 |
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| Drugbank entries | Show/Hide entries for SLC6A4 |
| Comment | NHLH2 acts as an activator of 5-HT metabolism, while FOXO1 acts as a repressor in SIRT1 signaling. |
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Formal Description Interaction-ID: 102280 |
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| Comment | FOXO1 is involved in the valproate-induced activation of MAO-A gene expression, catalytic activity, and promoter activity. FOXO1 represses the transcription of MAO-A by directly binding to a FOXO1-binding site of the MAO-A promoter. |
|
Formal Description Interaction-ID: 102281 |
|
| Drugbank entries | Show/Hide entries for Valproic acid or MAOA |
| Comment | CRH mRNA expression is increased by the intracerebroventricular administration of 5-HTP (precursor of 5-HT) and fluoxetine (selective serotonin reuptake inhibitor) as well as the intracerebroventricular administration of specific 5-HT1A, 5-HT1B, 5-HT2A, or 5-HT2C receptor agonist but not by specific 5-HT3 receptor agonist. |
|
Formal Description Interaction-ID: 102282 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Fluoxetine or CRH |
| Comment | CRH mRNA expression is increased by the intracerebroventricular administration of 5-HTP (precursor of 5-HT) and fluoxetine (selective serotonin reuptake inhibitor) as well as the intracerebroventricular administration of specific 5-HT1A, 5-HT1B, 5-HT2A, or 5-HT2C receptor agonist but not by specific 5-HT3 receptor agonist. |
|
Formal Description Interaction-ID: 102283 |
drug/chemical compound HTR1A agonist increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for CRH |
| Comment | CRH mRNA expression is increased by the intracerebroventricular administration of 5-HTP (precursor of 5-HT) and fluoxetine (selective serotonin reuptake inhibitor) as well as the intracerebroventricular administration of specific 5-HT1A, 5-HT1B, 5-HT2A, or 5-HT2C receptor agonist but not by specific 5-HT3 receptor agonist. |
|
Formal Description Interaction-ID: 102284 |
drug/chemical compound HTR1B agonist increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for CRH |
| Comment | CRH mRNA expression is increased by the intracerebroventricular administration of 5-HTP (precursor of 5-HT) and fluoxetine (selective serotonin reuptake inhibitor) as well as the intracerebroventricular administration of specific 5-HT1A, 5-HT1B, 5-HT2A, or 5-HT2C receptor agonist but not by specific 5-HT3 receptor agonist. |
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Formal Description Interaction-ID: 102285 |
drug/chemical compound HTR2C agonist increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for CRH |
| Comment | 5-HT signals influence the HPA-axis through the regulation of CRH levels in the brain. Intracerebroventricular injection of 5-HT induces the increase in CRH gene expression in the hypothalamic paraventricular nucleus of rats, which is abolished by pretreatment with a selective 5-HT1A receptor antagonist or a selective 5-HT3 receptor antagonist, rather than a selective 5-HT2A/2C receptor antagonist. |
|
Formal Description Interaction-ID: 102286 |
|
| Drugbank entries | Show/Hide entries for CRH |
| Comment | SIRT1 overexpression mice show higher MAO-A gene expression levels, lower 5-HT levels, and higher 5-HIAA levels in the brain, compared to wild-type mice. |
|
Formal Description Interaction-ID: 102288 |
|
| Comment | SIRT1 overexpression mice show higher MAO-A gene expression levels, lower 5-HT levels, and higher 5-HIAA levels in the brain, compared to wild-type mice. |
|
Formal Description Interaction-ID: 102289 |
gene/protein increases_quantity of drug/chemical compound |
| Comment | Brain-specific SIRT1 knockout mice show lower MAOA gene expression levels, higher 5-HT levels, lower 5-HIAA levels in the brain and less susceptibility to social defeat stress, compared to wild-type mice. |
|
Formal Description Interaction-ID: 102290 |
organism model SIRT1 KO mouse increases_quantity of drug/chemical compound |
| Comment | Brain-specific SIRT1 knockout mice show lower MAOA gene expression levels, higher 5-HT levels, lower 5-HIAA levels in the brain and less susceptibility to social defeat stress, compared to wild-type mice. |
|
Formal Description Interaction-ID: 102291 |
organism model SIRT1 KO mouse decreases_quantity of drug/chemical compound |
| Comment | Patients with MDD show significantly lower SIRT1 mRNA levels in peripheral white blood cells in depressive states whereas this reduction in SIRT1 mRNA is not observed in MDD patients in remissive state, implying that SIRT1 in peripheral white blood cells could be utilized as a potential state-dependent biomarker for MDD. |
|
Formal Description Interaction-ID: 102292 |
disease NOT affects_expression of gene/protein |
| Comment | An association between SIRT1 single nucleotide polymorphism and several psychiatric disorders, including social phobia (rs12778366), anxiety disorder (rs10997870), and panic disorder (rs12778366 and rs10997870) has been reported which indicates that SIRT1 is associated with mental disorders in humans. |
|
Formal Description Interaction-ID: 102293 |
|
| Comment | An association between SIRT1 single nucleotide polymorphism and several psychiatric disorders, including social phobia (rs12778366), anxiety disorder (rs10997870), and panic disorder (rs12778366 and rs10997870) has been reported which indicates that SIRT1 is associated with mental disorders in humans. |
|
Formal Description Interaction-ID: 102294 |
|
| Comment | An association between SIRT1 single nucleotide polymorphism and several psychiatric disorders, including social phobia (rs12778366), anxiety disorder (rs10997870), and panic disorder (rs12778366 and rs10997870) has been reported which indicates that SIRT1 is associated with mental disorders in humans. |
|
Formal Description Interaction-ID: 102295 |
|
| Comment | An association between SIRT1 SNP (rs10997875) and MDD in Japanese subjects has also been reported. |
|
Formal Description Interaction-ID: 104453 |
|
| Comment | In animal models, chronic social defeat stress increases SIRT1 mRNA and protein levels in the nucleus accumbens. |
|
Formal Description Interaction-ID: 136249 |
environment chronic social defeat stress increases_quantity of gene/protein |