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Field	Query

	Field	Term

General Information:

Id:	9,659
Diseases:	Alzheimer disease - [OMIM] Mental
Organism:	Mus musculus
Publication type:	article/cited
Reference:	Yun HM et al.(2015) Serotonin 6 receptor controls Alzheimers disease and depression Oncotarget 6 [PMID: 26449188]

Interaction Information:

Comment	5-HT6R modulates cognitive impairment, amyloidogenesis, and neuroinflammation in the AD mouse model.
Formal Description Interaction-ID: 101927	gene/protein HTR6 affects_activity of phenotype cognitive impairment in the AD mouse model
Drugbank entries	Show/Hide entries for HTR6
Drugbank DB00246	Ziprasidone antagonist HTR6
Drugbank DB00334	Olanzapine antagonist HTR6
Drugbank DB00363	Clozapine antagonist HTR6
Drugbank DB01224	Quetiapine other/unknown HTR6
Drugbank DB01238	Aripiprazole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6
Drugbank DB06144	Sertindole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6

Comment	5-HT6R antagonist, SB271036 rescued memory impairment by attenuating the generation of Abeta via the inhibition of gamma-secretase activity and the inactivation of astrocytes and microglia in the AD mouse model.
Formal Description Interaction-ID: 101928	drug/chemical compound SB271036 decreases_activity of gene/protein HTR6
Drugbank entries	Show/Hide entries for HTR6
Drugbank DB00246	Ziprasidone antagonist HTR6
Drugbank DB00334	Olanzapine antagonist HTR6
Drugbank DB00363	Clozapine antagonist HTR6
Drugbank DB01224	Quetiapine other/unknown HTR6
Drugbank DB01238	Aripiprazole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6
Drugbank DB06144	Sertindole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6

Comment	The reduction of serotonin level was significantly recovered by SB271036, which was mediated by an indirect regulation of serotonergic neurons via GABA.
Formal Description Interaction-ID: 101929	drug/chemical compound SB271036 increases_quantity of drug/chemical compound Serotonin mediated by an indirect regulation of serotonergic neurons via GABA

Comment	Selective serotonin reuptake inhibitor (SSRI), fluoxetine significantly improved cognitive impairment and behavioral changes.
Formal Description Interaction-ID: 101930	drug/chemical compound Fluoxetine decreases_activity of phenotype cognitive impairment improving cognitive impairment and behavioral changes
Drugbank entries	Show/Hide entries for Fluoxetine
Drugbank DB00472	Fluoxetine inhibitor SLC6A4
Drugbank DB00472	Fluoxetine antagonist HTR2A
Drugbank DB00472	Fluoxetine inhibitor SLC6A4

Comment	5-HT6R regulates memory impairment and serotonin, which is reduced by GABA in the AD mouse model.
Formal Description Interaction-ID: 101931	gene/protein HTR6 affects_activity of phenotype memory impairment
Drugbank entries	Show/Hide entries for HTR6
Drugbank DB00246	Ziprasidone antagonist HTR6
Drugbank DB00334	Olanzapine antagonist HTR6
Drugbank DB00363	Clozapine antagonist HTR6
Drugbank DB01224	Quetiapine other/unknown HTR6
Drugbank DB01238	Aripiprazole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6
Drugbank DB06144	Sertindole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6

Comment	APBA1/2 related with amyloid beta A4 precursor protein (APP) metabolism in AD was correlated with 5-HT6R in depression patients, and regulated by 5-HT6R in the AD mouse model, suggesting significant implications for the network of 5-HT6R between AD and depression.
Formal Description Interaction-ID: 101932	gene/protein HTR6 affects_expression of gene/protein APBA1 in the AD mouse model
Drugbank entries	Show/Hide entries for HTR6
Drugbank DB00246	Ziprasidone antagonist HTR6
Drugbank DB00334	Olanzapine antagonist HTR6
Drugbank DB00363	Clozapine antagonist HTR6
Drugbank DB01224	Quetiapine other/unknown HTR6
Drugbank DB01238	Aripiprazole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6
Drugbank DB06144	Sertindole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6

Comment	Expression level of APBA2 (amyloid beta (A4) precursor protein-binding, family A, member 2) was significantly correlated with serotonin level in depression patients and AD mouse model.
Formal Description Interaction-ID: 101933	phenotype abnormal depression-related behavior affects_expression of gene/protein APBA2 in AD mouse model; expression level of APBA2 was significantly correlated with serotonin level

Comment	In APP mutant mice of AD, it was also found that level of 5-HT6R mRNA was reduced in parallel with APBA2.
Formal Description Interaction-ID: 101936	disease Alzheimer disease decreases_quantity of gene/protein HTR6 in APP mutant mice of AD; level of 5-HT6R mRNA was reduced in parallel with APBA2
Drugbank entries	Show/Hide entries for HTR6
Drugbank DB00246	Ziprasidone antagonist HTR6
Drugbank DB00334	Olanzapine antagonist HTR6
Drugbank DB00363	Clozapine antagonist HTR6
Drugbank DB01224	Quetiapine other/unknown HTR6
Drugbank DB01238	Aripiprazole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6
Drugbank DB06144	Sertindole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6

Comment	5-HT6R is expressed on dorsal raphe nucleus (DRN) and its target region, cortex and hippocampus regions (CA1, CA3, and DG), and WAY-181187 tonically decreased serotonin level, which was attenuated by SB271046. (cited information)
Formal Description Interaction-ID: 101937	gene/protein HTR6 is_expressed_in tissue/cell line dorsal raphe nucleus
Drugbank entries	Show/Hide entries for HTR6
Drugbank DB00246	Ziprasidone antagonist HTR6
Drugbank DB00334	Olanzapine antagonist HTR6
Drugbank DB00363	Clozapine antagonist HTR6
Drugbank DB01224	Quetiapine other/unknown HTR6
Drugbank DB01238	Aripiprazole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6
Drugbank DB06144	Sertindole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6

Comment	5-HT6R indirectly regulates serotonin level in the AD mouse model. It is suggested that 5-HT6R controls serotonin level via GABAergic neurons but not serotonergic neurons in the AD mouse model.
Formal Description Interaction-ID: 101938	gene/protein HTR6 affects_quantity of drug/chemical compound Serotonin in the AD mouse model; via an indirect regulation
Drugbank entries	Show/Hide entries for HTR6
Drugbank DB00246	Ziprasidone antagonist HTR6
Drugbank DB00334	Olanzapine antagonist HTR6
Drugbank DB00363	Clozapine antagonist HTR6
Drugbank DB01224	Quetiapine other/unknown HTR6
Drugbank DB01238	Aripiprazole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6
Drugbank DB06144	Sertindole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6

Comment	Scopolamine-induced cognitive dysfunction was attenuated by 5-HT6R.
Formal Description Interaction-ID: 101939	drug/chemical compound Scopolamine increases_activity of phenotype cognitive impairment
Drugbank entries	Show/Hide entries for Scopolamine
Drugbank DB00747	Scopolamine antagonist CHRM1
Drugbank DB00747	Scopolamine inhibitor SI
Drugbank DB00747	Scopolamine antagonist CHRM2
Drugbank DB00747	Scopolamine antagonist CHRM3
Drugbank DB00747	Scopolamine antagonist CHRM4
Drugbank DB00747	Scopolamine antagonist CHRM5
Drugbank DB00747	Scopolamine antagonist CHRM1

Comment	5-HT6R attenuated the amyloid generation in the AD mouse model. The effect of 5-HT6R is likely attributable to the activity of gamma-secretase but not beta-secretase activity.
Formal Description Interaction-ID: 101940	gene/protein HTR6 decreases_quantity of gene/protein Amyloid beta peptide in the AD mouse model
Drugbank entries	Show/Hide entries for HTR6
Drugbank DB00246	Ziprasidone antagonist HTR6
Drugbank DB00334	Olanzapine antagonist HTR6
Drugbank DB00363	Clozapine antagonist HTR6
Drugbank DB01224	Quetiapine other/unknown HTR6
Drugbank DB01238	Aripiprazole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6
Drugbank DB06144	Sertindole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6

Comment	SB270146 and Fluoxetine reduced gamma-secretase activity and did not affect beta-secretase activity in the AD mouse model.
Formal Description Interaction-ID: 101941	drug/chemical compound Fluoxetine decreases_activity of complex/PPI Gamma-secretase complex in the AD mouse model
Drugbank entries	Show/Hide entries for Fluoxetine
Drugbank DB00472	Fluoxetine inhibitor SLC6A4
Drugbank DB00472	Fluoxetine antagonist HTR2A
Drugbank DB00472	Fluoxetine inhibitor SLC6A4

Comment	Administration of SSRIs reduced brain Abeta levels in mice, and also two components of the gamma-secretase complex, presenilin (PS)-1 and nicastrin were significantly reduced in a SSRI, citalopram-treated mice. (cited information)
Formal Description Interaction-ID: 101942	drug/chemical compound SSRI decreases_quantity of gene/protein Amyloid beta peptide in brain of mouse

Comment	APBA1/2 directly interacted with APP and gamma-secretase and impaired gamma-secretase activity to inhibit Abeta metabolisms in AD. Thus, it is suggested that the regulation of APBA1/2 via 5-HT6R improves cognitive dysfunction in the AD mouse model by inhibiting gamma-secretase activity. (cited information)
Formal Description Interaction-ID: 101943	gene/protein APBA1 interacts (colocalizes) with gene/protein APP
Drugbank entries	Show/Hide entries for APP
Drugbank DB02235	Methionine Sulfoxide not specified APP
Drugbank DB02235	Methionine Sulfoxide not specified APP

Comment	Serotonin level was lowered by Abeta1-42 infusion, however SB271046 rescued serotonin level in AD mouse model.
Formal Description Interaction-ID: 101946	gene/protein Amyloid beta peptide (42) decreases_quantity of drug/chemical compound Serotonin in AD mouse model; by Abeta1-42 infusion

Comment	A selective serotonin reuptake inhibitor (SSRI), Fluoxetine showed significantly better performance on the water maze test in AD mouse model.
Formal Description Interaction-ID: 101947	drug/chemical compound Fluoxetine decreases_activity of disease Alzheimer disease in AD mouse model
Drugbank entries	Show/Hide entries for Fluoxetine
Drugbank DB00472	Fluoxetine inhibitor SLC6A4
Drugbank DB00472	Fluoxetine antagonist HTR2A
Drugbank DB00472	Fluoxetine inhibitor SLC6A4

Comment	Expression level of APBA2 (amyloid beta (A4) precursor protein-binding, family A, member 2) was significantly correlated with serotonin level in depression patients and AD mouse model.
Formal Description Interaction-ID: 101949	phenotype abnormal depression-related behavior affects_expression of drug/chemical compound Serotonin in AD mouse model; expression level of APBA2 was significantly correlated with serotonin level

Comment	5-HT6R modulates cognitive impairment, amyloidogenesis, and neuroinflammation in the AD mouse model.
Formal Description Interaction-ID: 101951	gene/protein HTR6 affects_activity of phenotype amyloidosis in the AD mouse model
Drugbank entries	Show/Hide entries for HTR6
Drugbank DB00246	Ziprasidone antagonist HTR6
Drugbank DB00334	Olanzapine antagonist HTR6
Drugbank DB00363	Clozapine antagonist HTR6
Drugbank DB01224	Quetiapine other/unknown HTR6
Drugbank DB01238	Aripiprazole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6
Drugbank DB06144	Sertindole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6

Comment	5-HT6R modulates cognitive impairment, amyloidogenesis, and neuroinflammation in the AD mouse model.
Formal Description Interaction-ID: 101952	gene/protein HTR6 affects_activity of phenotype neuroinflammation in the AD mouse model
Drugbank entries	Show/Hide entries for HTR6
Drugbank DB00246	Ziprasidone antagonist HTR6
Drugbank DB00334	Olanzapine antagonist HTR6
Drugbank DB00363	Clozapine antagonist HTR6
Drugbank DB01224	Quetiapine other/unknown HTR6
Drugbank DB01238	Aripiprazole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6
Drugbank DB06144	Sertindole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6

Comment	5-HT6R antagonist, SB271036 rescued memory impairment by attenuating the generation of Abeta via the inhibition of gamma-secretase activity and the inactivation of astrocytes and microglia in the AD mouse model.
Formal Description Interaction-ID: 101953	drug/chemical compound SB271036 decreases_quantity of gene/protein Amyloid beta peptide in the AD mouse model; attenuating the generation of Abeta via the inhibition of gamma-secretase activity and the inactivation of astrocytes and microglia

Comment	5-HT6R antagonist, SB271036 rescued memory impairment by attenuating the generation of Abeta via the inhibition of gamma-secretase activity and the inactivation of astrocytes and microglia in the AD mouse model.
Formal Description Interaction-ID: 101954	drug/chemical compound SB271036 decreases_activity of complex/PPI Gamma-secretase complex in the AD mouse model; attenuating the generation of Abeta via the inhibition of gamma-secretase activity and the inactivation of astrocytes and microglia

Comment	5-HT6R antagonist, SB271036 rescued memory impairment by attenuating the generation of Abeta via the inhibition of gamma-secretase activity and the inactivation of astrocytes and microglia in the AD mouse model.
Formal Description Interaction-ID: 101955	drug/chemical compound SB271036 decreases_activity of tissue/cell line astrocyte in the AD mouse model; attenuating the generation of Abeta via the inhibition of gamma-secretase activity and the inactivation of astrocytes and microglia

Comment	5-HT6R antagonist, SB271036 rescued memory impairment by attenuating the generation of Abeta via the inhibition of gamma-secretase activity and the inactivation of astrocytes and microglia in the AD mouse model.
Formal Description Interaction-ID: 101956	drug/chemical compound SB271036 decreases_activity of tissue/cell line microglia in the AD mouse model; attenuating the generation of Abeta via the inhibition of gamma-secretase activity and the inactivation of astrocytes and microglia

Comment	5-HT6R regulates memory impairment and serotonin, which is reduced by GABA in the AD mouse model.
Formal Description Interaction-ID: 101957	gene/protein HTR6 affects_quantity of drug/chemical compound Serotonin in the AD mouse model; concerning GABA reduced serotonin
Drugbank entries	Show/Hide entries for HTR6
Drugbank DB00246	Ziprasidone antagonist HTR6
Drugbank DB00334	Olanzapine antagonist HTR6
Drugbank DB00363	Clozapine antagonist HTR6
Drugbank DB01224	Quetiapine other/unknown HTR6
Drugbank DB01238	Aripiprazole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6
Drugbank DB06144	Sertindole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6

Comment	5-HT6R regulates memory impairment and serotonin, which is reduced by GABA in the AD mouse model.
Formal Description Interaction-ID: 101958	drug/chemical compound GABA decreases_quantity of drug/chemical compound Serotonin in the AD mouse model

Comment	APBA1/2 related with amyloid beta A4 precursor protein (APP) metabolism in AD was correlated with 5-HT6R in depression patients, and regulated by 5-HT6R in the AD mouse model, suggesting significant implications for the network of 5-HT6R between AD and depression.
Formal Description Interaction-ID: 101960	gene/protein HTR6 affects_expression of gene/protein APBA2 in the AD mouse model
Drugbank entries	Show/Hide entries for HTR6
Drugbank DB00246	Ziprasidone antagonist HTR6
Drugbank DB00334	Olanzapine antagonist HTR6
Drugbank DB00363	Clozapine antagonist HTR6
Drugbank DB01224	Quetiapine other/unknown HTR6
Drugbank DB01238	Aripiprazole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6
Drugbank DB06144	Sertindole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6

Comment	In APP mutant mice of AD, it was also found that level of 5-HT6R mRNA was reduced in parallel with APBA2.
Formal Description Interaction-ID: 101964	disease Alzheimer disease decreases_quantity of gene/protein APBA2 in APP mutant mice of AD; level of 5-HT6R mRNA was reduced in parallel with APBA2

Comment	5-HT6R is expressed on dorsal raphe nucleus (DRN) and its target region, cortex and hippocampus regions (CA1, CA3, and DG), and WAY-181187 tonically decreased serotonin level, which was attenuated by SB271046. (cited information)
Formal Description Interaction-ID: 101967	gene/protein HTR6 affects_activity of tissue/cell line cerebral cortex target region of 5-HT6R
Drugbank entries	Show/Hide entries for HTR6
Drugbank DB00246	Ziprasidone antagonist HTR6
Drugbank DB00334	Olanzapine antagonist HTR6
Drugbank DB00363	Clozapine antagonist HTR6
Drugbank DB01224	Quetiapine other/unknown HTR6
Drugbank DB01238	Aripiprazole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6
Drugbank DB06144	Sertindole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6

Comment	5-HT6R is expressed on dorsal raphe nucleus (DRN) and its target region, cortex and hippocampus regions (CA1, CA3, and DG), and WAY-181187 tonically decreased serotonin level, which was attenuated by SB271046. (cited information)
Formal Description Interaction-ID: 101969	gene/protein HTR6 affects_activity of tissue/cell line hippocampus target region of 5-HT6R; concerning the hippocampus regions CA1, CA3, and DG;
Drugbank entries	Show/Hide entries for HTR6
Drugbank DB00246	Ziprasidone antagonist HTR6
Drugbank DB00334	Olanzapine antagonist HTR6
Drugbank DB00363	Clozapine antagonist HTR6
Drugbank DB01224	Quetiapine other/unknown HTR6
Drugbank DB01238	Aripiprazole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6
Drugbank DB06144	Sertindole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6

Comment	Scopolamine-induced cognitive dysfunction was attenuated by 5-HT6R.
Formal Description Interaction-ID: 101971	gene/protein HTR6 decreases_activity of drug/chemical compound Scopolamine
Drugbank entries	Show/Hide entries for HTR6 or Scopolamine
Drugbank DB00246	Ziprasidone antagonist HTR6
Drugbank DB00334	Olanzapine antagonist HTR6
Drugbank DB00363	Clozapine antagonist HTR6
Drugbank DB01224	Quetiapine other/unknown HTR6
Drugbank DB01238	Aripiprazole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6
Drugbank DB06144	Sertindole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6
Drugbank DB00747	Scopolamine antagonist CHRM1
Drugbank DB00747	Scopolamine inhibitor SI
Drugbank DB00747	Scopolamine antagonist CHRM2
Drugbank DB00747	Scopolamine antagonist CHRM3
Drugbank DB00747	Scopolamine antagonist CHRM4
Drugbank DB00747	Scopolamine antagonist CHRM5
Drugbank DB00747	Scopolamine antagonist CHRM1

Comment	5-HT6R attenuated the amyloid generation in the AD mouse model. The effect of 5-HT6R is likely attributable to the activity of gamma-secretase but not beta-secretase activity.
Formal Description Interaction-ID: 101973	gene/protein HTR6 decreases_activity of disease Alzheimer disease in the AD mouse model; via attenuating the amyloid generation
Drugbank entries	Show/Hide entries for HTR6
Drugbank DB00246	Ziprasidone antagonist HTR6
Drugbank DB00334	Olanzapine antagonist HTR6
Drugbank DB00363	Clozapine antagonist HTR6
Drugbank DB01224	Quetiapine other/unknown HTR6
Drugbank DB01238	Aripiprazole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6
Drugbank DB06144	Sertindole antagonist HTR6
Drugbank DB01488	Dimethyltryptamine not specified HTR6

Comment	SB270146 and Fluoxetine reduced gamma-secretase activity and did not affect beta-secretase activity in the AD mouse model.
Formal Description Interaction-ID: 101974	drug/chemical compound SB270146 decreases_activity of complex/PPI Gamma-secretase complex in the AD mouse model

Comment	Administration of SSRIs reduced brain Abeta levels in mice, and also two components of the gamma-secretase complex, presenilin (PS)-1 and nicastrin were significantly reduced in a SSRI, citalopram-treated mice. (cited information)
Formal Description Interaction-ID: 101975	drug/chemical compound Citalopram decreases_activity of complex/PPI Gamma-secretase complex in mice; via reducing two components of the gamma-secretase complex, presenilin (PS)-1 and nicastrin
Drugbank entries	Show/Hide entries for Citalopram
Drugbank DB00215	Citalopram inhibitor SLC6A4
Drugbank DB00215	Citalopram inhibitor SLC6A4

Comment	Administration of SSRIs reduced brain Abeta levels in mice, and also two components of the gamma-secretase complex, presenilin (PS)-1 and nicastrin were significantly reduced in a SSRI, citalopram-treated mice. (cited information)
Formal Description Interaction-ID: 101976	drug/chemical compound Citalopram decreases_expression of gene/protein PSEN1 in mice
Drugbank entries	Show/Hide entries for Citalopram
Drugbank DB00215	Citalopram inhibitor SLC6A4
Drugbank DB00215	Citalopram inhibitor SLC6A4

Comment	Administration of SSRIs reduced brain Abeta levels in mice, and also two components of the gamma-secretase complex, presenilin (PS)-1 and nicastrin were significantly reduced in a SSRI, citalopram-treated mice. (cited information)
Formal Description Interaction-ID: 101977	drug/chemical compound Citalopram decreases_expression of gene/protein NCSTN in mice
Drugbank entries	Show/Hide entries for Citalopram
Drugbank DB00215	Citalopram inhibitor SLC6A4
Drugbank DB00215	Citalopram inhibitor SLC6A4

Comment	APBA1/2 directly interacted with APP and gamma-secretase and impaired gamma-secretase activity to inhibit Abeta metabolisms in AD. Thus, it is suggested that the regulation of APBA1/2 via 5-HT6R improves cognitive dysfunction in the AD mouse model by inhibiting gamma-secretase activity. (cited information)
Formal Description Interaction-ID: 101978	gene/protein APBA2 interacts (colocalizes) with gene/protein APP
Drugbank entries	Show/Hide entries for APP
Drugbank DB02235	Methionine Sulfoxide not specified APP
Drugbank DB02235	Methionine Sulfoxide not specified APP

Comment	APBA1/2 directly interacted with APP and gamma-secretase and impaired gamma-secretase activity to inhibit Abeta metabolisms in AD. Thus, it is suggested that the regulation of APBA1/2 via 5-HT6R improves cognitive dysfunction in the AD mouse model by inhibiting gamma-secretase activity. (cited information)
Formal Description Interaction-ID: 101979	gene/protein APBA1 interacts (colocalizes) with complex/PPI Gamma-secretase complex inhibiting Abeta metabolisms in AD

Comment	APBA1/2 directly interacted with APP and gamma-secretase and impaired gamma-secretase activity to inhibit Abeta metabolisms in AD. Thus, it is suggested that the regulation of APBA1/2 via 5-HT6R improves cognitive dysfunction in the AD mouse model by inhibiting gamma-secretase activity. (cited information)
Formal Description Interaction-ID: 101980	gene/protein APBA2 interacts (colocalizes) with complex/PPI Gamma-secretase complex inhibiting Abeta metabolisms in AD

Comment	APBA1/2 directly interacted with APP and gamma-secretase and impaired gamma-secretase activity to inhibit Abeta metabolisms in AD. Thus, it is suggested that the regulation of APBA1/2 via 5-HT6R improves cognitive dysfunction in the AD mouse model by inhibiting gamma-secretase activity. (cited information)
Formal Description Interaction-ID: 101981	gene/protein APBA1 decreases_activity of complex/PPI Gamma-secretase complex inhibiting Abeta metabolisms in AD

Comment	APBA1/2 directly interacted with APP and gamma-secretase and impaired gamma-secretase activity to inhibit Abeta metabolisms in AD. Thus, it is suggested that the regulation of APBA1/2 via 5-HT6R improves cognitive dysfunction in the AD mouse model by inhibiting gamma-secretase activity. (cited information)
Formal Description Interaction-ID: 101982	gene/protein APBA2 decreases_activity of complex/PPI Gamma-secretase complex inhibiting Abeta metabolisms in AD

Comment	Serotonin level was lowered by Abeta1-42 infusion, however SB271046 rescued serotonin level in AD mouse model.
Formal Description Interaction-ID: 101984	drug/chemical compound SB271046 decreases_activity of gene/protein Amyloid beta peptide (42) in AD mouse model; after Abeta1-42 infusion

Comment	Serotonin level was lowered by Abeta1-42 infusion, however SB271046 rescued serotonin level in AD mouse model.
Formal Description Interaction-ID: 101985	drug/chemical compound SB271046 increases_quantity of drug/chemical compound Serotonin in AD mouse model; concerning lowered serotonin level after Abeta1-42 infusion

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