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Field	Query

	Field	Term

General Information:

Id:	938
Diseases:	Parkinson disease
Organism:	Mus musculus
Organism Model:	cNurr1DATCre mouse
Tissue/Cell line:	BTO:0000138 midbrain
Publication type:	article
Reference:	Kadkhodaei B et al.(2009) Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons. J. Neurosci. 29 [PMID: 20016108]

Interaction Information:

Comment	Nurr1 deficiency in maturing mDA neurons resulted in rapid loss of striatal DA, loss of mDA neuron markers, and neuron degeneration.
Formal Description Interaction-ID: 5677	gene/protein NR4A2 affects_quantity of drug/chemical compound Dopamine in brain
Drugbank entries	Show/Hide entries for
Drugbank DB00988	Dopamine agonist DRD1
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00988	Dopamine agonist DRD5
Drugbank DB00988	Dopamine agonist DRD2
Drugbank DB00988	Dopamine agonist DRD3
Drugbank DB00988	Dopamine agonist DRD4
Drugbank DB00988	Dopamine inducer SLC6A3

Comment	Nurr1 deficiency in maturing mDA neurons resulted in rapid loss of striatal DA, loss of mDA neuron markers, and neuron degeneration.
Formal Description Interaction-ID: 5680	gene/protein NR4A2 decreases_activity of process neuron death in brain

Comment	The transcription factor Nurr1 is essential for early differentiation of midbrain dopamine neurons but continues to be expressed into adulthood. In Parkinson disease, Nurr1 expression is diminished.
Formal Description Interaction-ID: 5683	disease Parkinson disease decreases_quantity of gene/protein NR4A2

Comment	Nurr1 is involved in dopaminergic neuron differentiation.
Formal Description Interaction-ID: 5687	gene/protein NR4A2 increases_activity of process dopaminergic neuron differentiation

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