CIDeRplusGeneral Information:
| Id: | 9,377 (click here to show other Interactions for entry) |
| Diseases: |
Hypophosphatasia, adult
- [OMIM]
Hypophosphatasia, childhood - [OMIM] Hypophosphatasia, infantile - [OMIM] |
| Mammalia | |
| review | |
| Reference: | Rader BA(2017) Alkaline Phosphatase, an Unconventional Immune Protein Front Immunol 8: 897 [PMID: 28824625] |
Interaction Information:
| Comment | Pyridoxal-5-phosphate, the active form of vitamin B6, is elevated in the serum of HPP patients. Hydrolysis of PLP to pyridoxal (PL) by TNAP facilitates diffusion of PL across cell membranes, where it is then re-phosphorylated into PLP. PLP is a versatile cofactor for an estimated 4% of enzymatic reactions and is used by over 110 enzymes to produce or metabolize various molecules. PLP-dependent enzymes in the brain are responsible for the production of important neurochemicals including serotonin, dopamine, and gamma-aminobutyric acid. The decrease in PLP and resulting decrease in PLP-dependent metabolism in the brain in perinatal HPP patients has been implicated as the cause of neonatal seizures. |
|
Formal Description Interaction-ID: 100041 |
drug/chemical compound increases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for Pyridoxal phosphate |