CIDeRplusGeneral Information:
| Id: | 9,210 (click here to show other Interactions for entry) |
| Diseases: |
Gastrointestinal
Metabolic |
| Mus musculus | |
| article | |
| Reference: | Lyte M and Bailey MT(1997) Neuroendocrine-bacterial interactions in a neurotoxin-induced model of trauma J. Surg. Res. 70: 195-201 [PMID: 9245571] |
Interaction Information:
| Comment | To examine whether destruction of noradrenergic neurons may directly influence the growth of indigenous bacteria in vivo, the selective noradrenergic neurotoxic agent 6-hydroxydopamine (6-OHDA) was employed in a murine model of trauma-induced norepinephrine release. An increase of 3‚Äď5 logs in the total gram-negative population, most notably Escherichia coli, compared to controls on a per gram equivalent basis was observed at 1 day post-6-OHDA. Neurotoxin-induced alterations in cecal flora were completely inhibited by the prior administration of the catecholamine uptake blocker desipramine hydrochloride, indicating the specificity of the effect being due to the rereleased norepinephrine. |
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Formal Description Interaction-ID: 97685 |
drug/chemical compound increases_activity of environment altered gut microbiota composition |