General Information:

Id: 921
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0000932 neuroblastoma cell line; SK-N-SH neuroblastoma cells
article
Reference: Gomes E and Rockwell P(2008) p38 MAPK as a negative regulator of VEGF/VEGFR2 signaling pathway in serum deprived human SK-N-SH neuroblastoma cells Neurosci. Lett. 431: 95-100 [PMID: 18178312]

Interaction Information:

Comment SB202190 is a selective inhibitor of p38 MAPK (MAPK14).
Formal Description
Interaction-ID: 5561

drug/chemical compound

SB202190

decreases_activity of

gene/protein

MAPK14

Drugbank entries Show/Hide entries for MAPK14
Comment SU1498 is a selective inhibitor of VEGFR2 (KDR).
Formal Description
Interaction-ID: 5563

drug/chemical compound

SU1498

decreases_activity of

gene/protein

KDR

Drugbank entries Show/Hide entries for KDR
Comment Inhibition of VEGFR2 by SU1498 in serum starved neuroblastoma cells reduced the viability of the cells.
Formal Description
Interaction-ID: 5564

drug/chemical compound

SU1498

increases_activity of

process

cell death

Comment Inhibition of p38 MAPK (MAPK14) by SB202190 in serum starved neuroblastoma cells increases the viability of the cells.
Formal Description
Interaction-ID: 5567

drug/chemical compound

SB202190

decreases_activity of

process

cell death

Comment VEGFR2 inhibition abrogated Akt and ERK1/2 activation in VEGF treated cells irrespective of p38 MAPK inhibition.
Formal Description
Interaction-ID: 5568

gene/protein

KDR

increases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for KDR or AKT1
Comment VEGFR2 inhibition abrogated Akt and ERK1/2 activation in VEGF treated cells irrespective of p38 MAPK inhibition.
Formal Description
Interaction-ID: 128940

gene/protein

KDR

increases_activity of

process

ERK1 and ERK2 cascade

Drugbank entries Show/Hide entries for KDR