General Information:

Id: 9,139
Diseases: Gastrointestinal
Mental
Metabolic
Mammalia
review
Reference: Lyte M(2014) Microbial endocrinology and the microbiota-gut-brain axis Adv. Exp. Med. Biol. 817: 3-24 [PMID: 24997027]

Interaction Information:

Comment Reduced anxiety-like and depressive-like behavior in mice fed the probiotic strain L.rhamnosus (JB-1) was observed. Following probiotic administration they were able to demonstrate changes in the level of GABA(Aalpha2) mRNA in those brain regions associated with that specific behavior.
Formal Description
Interaction-ID: 96349

environment

Lactobacillus rhamnosus (JB-1)

increases_activity of

environment

Probiotics

in mice; fed the probiotic strain L.rhamnosus (JB-1)
Comment A study demonstrated that Lactobacillus brevis (FPA 3709) is able to produce GABA.
Formal Description
Interaction-ID: 97551

environment

Lactobacillus brevis (FPA 3709)

increases_quantity of

drug/chemical compound

GABA

Comment Reduced anxiety-like and depressive-like behavior in mice fed the probiotic strain L.rhamnosus (JB-1) was observed. Following probiotic administration they were able to demonstrate changes in the level of GABA(Aalpha2) mRNA in those brain regions associated with that specific behavior.
Formal Description
Interaction-ID: 97552

environment

Lactobacillus rhamnosus (JB-1)

decreases_activity of

phenotype

increased anxiety-related response

in mice; fed the probiotic strain L.rhamnosus (JB-1)
Comment Reduced anxiety-like and depressive-like behavior in mice fed the probiotic strain L.rhamnosus (JB-1) was observed. Following probiotic administration they were able to demonstrate changes in the level of GABA(Aalpha2) mRNA in those brain regions associated with that specific behavior.
Formal Description
Interaction-ID: 97553

environment

Lactobacillus rhamnosus (JB-1)

decreases_activity of

phenotype

abnormal depression-related behavior

in mice; fed the probiotic strain L.rhamnosus (JB-1)
Comment Reduced anxiety-like and depressive-like behavior in mice fed the probiotic strain L.rhamnosus (JB-1) was observed. Following probiotic administration they were able to demonstrate changes in the level of GABA(Aalpha2) mRNA in those brain regions associated with that specific behavior.
Formal Description
Interaction-ID: 97554

environment

Lactobacillus rhamnosus (JB-1)

affects_expression of

gene/protein

GABRA2

in mice; concerning GABA(Aalpha2) mRNA in those brain regions associated with anxiety-like and depressive-like behavior
Drugbank entries Show/Hide entries for GABRA2