CIDeRplusGeneral Information:
| Id: | 908 |
| Diseases: |
Alzheimer disease
- [OMIM]
|
| Mammalia | |
| review | |
| Reference: | Sun AY et al.(2008) Botanical phenolics and brain health Neuromolecular Med. 10: 259-274 [PMID: 19191039] |
Interaction Information:
| Comment | Increase in oxidative stress is associated with early development of Alzheimer's disease. |
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Formal Description Interaction-ID: 5414 |
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| Comment | Amyloid beta peptides can confer specific action on the N-methyl-D-aspartic acid (NMDA) receptors. |
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Formal Description Interaction-ID: 5415 |
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| Comment | One part of the oxidative mechanism affects the quantity of amyloid beta peptides (39-43 aa). |
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Formal Description Interaction-ID: 5416 |
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| Comment | Excess production of reactive oxygen species (ROS) in the brain has been implicated as a common underlying factor for the etiology of a number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and stroke. |
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Formal Description Interaction-ID: 5418 |
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| Comment | Abeta can induce ROS production in neurons through an NMDA receptor-dependent process. |
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Formal Description Interaction-ID: 5419 |
gene/protein increases_quantity of drug/chemical compound Reactive oxygen species |
| Comment | In astrocytes Abeta treatment was shown to cause the decrease in mitochondrial membrane potential, and this was partly due to activation of phospholipase. |
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Formal Description Interaction-ID: 5420 |
gene/protein decreases_activity of process |
| Comment | Mitochondrial dysfunction is associated with increased production of ROS and release of cytochrome C, which in turn, triggers the apoptotic pathways. |
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Formal Description Interaction-ID: 5421 |
drug/chemical compound Reactive oxygen species increases_activity of phenotype |
| Comment | Mitochondrial dysfunction is associated with increased production of ROS and release of cytochrome C, which in turn, triggers the apoptotic pathways. |
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Formal Description Interaction-ID: 5422 |
phenotype increases_activity of process |
| Comment | Abeta-mediated ROS production is also linked to increased inflammatory responses, including increased production of cytokines, nitric oxide and eicosanoids. |
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Formal Description Interaction-ID: 5423 |
drug/chemical compound Reactive oxygen species increases_activity of process |
| Comment | Abeta-mediated ROS production is also linked to increased inflammatory responses, including increased production of cytokines, nitric oxide and eicosanoids. |
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Formal Description Interaction-ID: 5430 |
drug/chemical compound Reactive oxygen species increases_activity of process |
| Comment | Abeta-mediated ROS production is also linked to increased inflammatory responses, including increased production of cytokines, nitric oxide and eicosanoids. |
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Formal Description Interaction-ID: 5432 |
drug/chemical compound Reactive oxygen species increases_activity of |
| Comment | Abeta-mediated ROS production is also linked to increased inflammatory responses, including increased production of cytokines, nitric oxide and eicosanoids. |
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Formal Description Interaction-ID: 5435 |
drug/chemical compound Reactive oxygen species increases_activity of process |
| Comment | Abeta-induced ROS from NADPH oxidase in astrocytes is a key factor in mediating neuronal death. |
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Formal Description Interaction-ID: 5441 |
drug/chemical compound Reactive oxygen species increases_activity of process |
| Comment | Neuroprotective effects of resveratrol are known. |
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Formal Description Interaction-ID: 5512 |
drug/chemical compound increases_activity of |
| Drugbank entries | Show/Hide entries for Resveratrol |
| Comment | Resveratrol is found in a variety of plant species and is used to treat fevers, hyperlipidemia, atherosclerosis, and inflammation. |
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Formal Description Interaction-ID: 5514 |
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| Drugbank entries | Show/Hide entries for Resveratrol |
| Comment | Resveratrol is found in a variety of plant species and is used to treat fevers, hyperlipidemia, atherosclerosis, and inflammation. |
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Formal Description Interaction-ID: 5515 |
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| Drugbank entries | Show/Hide entries for Resveratrol |
| Comment | Resveratrol is found in a variety of plant species and is used to treat fevers, hyperlipidemia, atherosclerosis, and inflammation. |
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Formal Description Interaction-ID: 5516 |
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| Drugbank entries | Show/Hide entries for Resveratrol |
| Comment | Resveratrol is found in a variety of plant species and is used to treat fevers, hyperlipidemia, atherosclerosis, and inflammation. |
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Formal Description Interaction-ID: 5517 |
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| Drugbank entries | Show/Hide entries for Resveratrol |
| Comment | Several studies demonstrated the ability for resveratrol to protect neurons against Abeta induced toxicity. |
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Formal Description Interaction-ID: 5519 |
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| Drugbank entries | Show/Hide entries for Resveratrol |
| Comment | Red wine consumption significantly attenuated AD-type deterioration of spatial memory function and Abeta neuropathology in Tg2576 mice. |
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Formal Description Interaction-ID: 5523 |
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| Comment | Red wine consumption significantly attenuated AD-type deterioration of spatial memory function and Abeta neuropathology in Tg2576 mice. |
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Formal Description Interaction-ID: 5526 |
environment Red wine consumption decreases_activity of phenotype Abeta pathology |
| Comment | Reveratrol is able to reduce Abeta secretion in several cell lines via a mechanism that involves the proteasome. |
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Formal Description Interaction-ID: 5528 |
drug/chemical compound decreases_quantity of gene/protein |
| Drugbank entries | Show/Hide entries for Resveratrol |
| Comment | A number of studies have demonstrated the ability of resveratrol to suppress neuroinflammatory responses, e.g., attenuating iNOS and COX-2 expression. |
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Formal Description Interaction-ID: 5531 |
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| Drugbank entries | Show/Hide entries for Resveratrol or PTGS2 |
| Comment | A number of studies have demonstrated the ability of resveratrol to suppress neuroinflammatory responses, e.g., attenuating iNOS and COX-2 expression. |
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Formal Description Interaction-ID: 5536 |
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| Drugbank entries | Show/Hide entries for Resveratrol or NOS2 |
| Comment | Curcumin can bind amyloid directly and inhibit Abeta aggregation. |
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Formal Description Interaction-ID: 5543 |
drug/chemical compound interacts (colocalizes) with gene/protein |
| Comment | Curcumin can bind amyloid directly and inhibit Abeta aggregation as well as prevent fibril and oligomer formation. |
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Formal Description Interaction-ID: 5544 |
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| Comment | Red wine consumption significantly attenuated AD-type deterioration of spatial memory function and Abeta neuropathology in Tg2576 mice. |
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Formal Description Interaction-ID: 5546 |
environment Red wine consumption decreases_quantity of phenotype |
| Comment | Both low and high doses of curcumin significantly lowered oxidized proteins and interleukin-1beta, a proinflammatory cytokine elevated in the brains of Tg2576 mice. |
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Formal Description Interaction-ID: 5548 |
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| Comment | Both low and high doses of curcumin significantly lowered oxidized proteins and interleukin-1beta, a proinflammatory cytokine elevated in the brains of Tg2576 mice. |
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Formal Description Interaction-ID: 5549 |
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| Drugbank entries | Show/Hide entries for IL1B |
| Comment | Curcumin offers antioxidant, anti-inflammatory and cholesterol lowering properties, all are important on ameliorating the deleterious consequences of AD. |
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Formal Description Interaction-ID: 5551 |
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| Comment | Curcumin offers antioxidant, anti-inflammatory and cholesterol lowering properties, all are important on ameliorating the deleterious consequences of AD. |
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Formal Description Interaction-ID: 5557 |
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| Comment | Neuroprotective effects of curcumin are known. |
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Formal Description Interaction-ID: 5562 |
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| Comment | Effects of common botanicals on Alzheimer disease. |
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Formal Description Interaction-ID: 5743 |
environment Vaccinium (blueberry plant) supplementation affects_activity of disease |
| Comment | Effects of common botanicals on Alzheimer disease. |
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Formal Description Interaction-ID: 5744 |
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| Drugbank entries | Show/Hide entries for Resveratrol |
| Comment | Effects of common botanicals on Alzheimer disease. |
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Formal Description Interaction-ID: 5745 |
environment Allium sativum (garlic) supplementation affects_activity of disease |
| Comment | Effects of common botanicals on Alzheimer disease. |
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Formal Description Interaction-ID: 5748 |
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| Drugbank entries | Show/Hide entries for Ginseng |
| Comment | Effects of common botanicals on Alzheimer disease. |
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Formal Description Interaction-ID: 5749 |
drug/chemical compound Ginkgo biloba affects_activity of disease |
| Drugbank entries | Show/Hide entries for Ginkgo biloba |
| Comment | Effects of common botanicals on Alzheimer disease. |
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Formal Description Interaction-ID: 5750 |
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| Comment | Effects of common botanicals on Alzheimer disease. |
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Formal Description Interaction-ID: 5751 |
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| Comment | Effects of common botanicals on Alzheimer disease. |
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Formal Description Interaction-ID: 5753 |
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| Comment | One part of the oxidative mechanism affects the quantity of amyloid beta peptides (39-43 aa). |
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Formal Description Interaction-ID: 10906 |
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| Comment | Excess production of reactive oxygen species (ROS) in the brain has been implicated as a common underlying factor for the etiology of a number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and stroke. |
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Formal Description Interaction-ID: 10999 |
drug/chemical compound Reactive oxygen species increases_activity of disease Parkinson disease |
| Comment | Curcumin can bind amyloid directly and inhibit Abeta aggregation as well as prevent fibril and oligomer formation. |
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Formal Description Interaction-ID: 80156 |
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| Comment | Curcumin can bind amyloid directly and inhibit Abeta aggregation as well as prevent fibril and oligomer formation. |
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Formal Description Interaction-ID: 80157 |
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