CIDeRplusGeneral Information:
| Id: | 8,967 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Cieslak M and Roszek K(2014) Purinergic signaling in the pancreas and the therapeutic potential of ecto-nucleotidases in diabetes Acta Biochim. Pol. 61: 655-662 [PMID: 25522227] |
Interaction Information:
| Comment | The granules inside the pancreatic cells contain not only insulin but also ATP and ADP - their release is regulated by the activation of P2X2 receptor present on the beta-cells. Moreover, other molecules as 5-hydroxytryptamine, gamma-aminobutyric acid, glutamate and zinc are released together with ATP and may affect the autocrine secretion of insulin. |
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Formal Description Interaction-ID: 93867 |
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