General Information:

Id: 885
Diseases: Parkinson disease
Mus musculus
BTO:0002701 brain, synaptosome
article
Reference: Fallon L et al.(2006) A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling. Nat. Cell Biol. 8: 834-842 [PMID: 16862145]

Interaction Information:

Comment EGF treatment induces both Akt and Erk phosphorylation in synaptosomes.
Formal Description
Interaction-ID: 5213

gene/protein

EGF

increases_phosphorylation of

gene/protein

AKT1

Drugbank entries Show/Hide entries for EGF or AKT1
Comment EGF treatment induces both Akt and Erk phosphorylation in synaptosomes.
Formal Description
Interaction-ID: 5214

gene/protein

EGF

increases_phosphorylation of

gene/protein

MAPK1

Drugbank entries Show/Hide entries for EGF or MAPK1
Comment Akt-, but not Erk-signalling is significantly decreased in parkin knockout compared with wild-type synaptosomes.
Formal Description
Interaction-ID: 5221

gene/protein

PRKN

NOT increases_phosphorylation of

gene/protein

MAPK1

in synaptosomes
Drugbank entries Show/Hide entries for MAPK1
Comment Akt-, but not Erk-signalling is significantly decreased in parkin knockout compared with wild-type synaptosomes.
Formal Description
Interaction-ID: 5223

gene/protein

PRKN

increases_activity of

process

protein kinase B signaling

in synaptosomes
Comment Akt-, but not Erk-signalling is significantly decreased in parkin knockout compared with wild-type synaptosomes.
Formal Description
Interaction-ID: 5224

gene/protein

PRKN

NOT increases_phosphorylation of

gene/protein

AKT1

in synaptosomes
Drugbank entries Show/Hide entries for AKT1
Comment Akt signaling plays a role in neuronal survival.
Formal Description
Interaction-ID: 5225

process

protein kinase B signaling

decreases_activity of

process

neuron death