General Information:

Id: 8,774
Diseases: Metabolic
Homo sapiens
article
Reference: Arinze IJ(2005) Facilitating understanding of the purine nucleotide cycle and the one-carbon pool: Part I: The purine nucleotide cycle Biochem Mol Biol Educ 33: 165-168 [PMID: 21638570]

Interaction Information:

Comment In the purine nucleotide cycle the amino group of aspartate is used in the adenylsuccinate synthetase reaction to convert IMP to adenylosuccinate.
Formal Description
Interaction-ID: 91289

drug/chemical compound

Aspartate

increases_quantity of

drug/chemical compound

Adenylosuccinate

via adenylosuccinate synthetase activity during the purine nucleotide cycle in the prsenece of IMP
Comment AMP allosterically stimulates phosphofructokinase 1 as well as glycogen phosphorylase b.
Formal Description
Interaction-ID: 91290

drug/chemical compound

AMP

increases_activity of

gene/protein

Glycogen phosphorylase

Comment Fumarate produced during the purine nucleotide cycle via the activity of ADSL, is funneled to the citric acid cycle. This enables the exercising muscle to make more ATP.
Formal Description
Interaction-ID: 91291

drug/chemical compound

Fumarate

increases_activity of

process

tricarboxylic acid cycle

Drugbank entries Show/Hide entries for Fumarate
Comment Fumarate produced during the purine nucleotide cycle via the activity of ADSL, is funneled to the citric acid cycle. This enables the exercising muscle to make more ATP.
Formal Description
Interaction-ID: 91292

process

tricarboxylic acid cycle

increases_quantity of

drug/chemical compound

ATP

Comment The muscle does not accumulate ammonia produced during the purine nucleotide cycle, instead it releases it in a nontoxic form as glutamine by the action of glutamine synthetase.
Formal Description
Interaction-ID: 91293

drug/chemical compound

NH3

increases_quantity of

drug/chemical compound

Glutamine

in muscle
Comment To replenish the citric acid cycle fumarate produced in the cytosol during the purine nucleotide cycle has to enter the mitochondrial matrix. Since the mitochondrial inner membrane does not possess a transporter for fumarate, it must first be converted to malate in the cytosol. Malate is then transportet into mitochondria via dicarboxylate carrier.
Formal Description
Interaction-ID: 91294

drug/chemical compound

Fumarate

increases_quantity of

drug/chemical compound

Malate

Drugbank entries Show/Hide entries for Fumarate
Comment The muscle does not accumulate ammonia produced during the purine nucleotide cycle, instead it releases it in a nontoxic form as glutamine by the action of glutamine synthetase.
Formal Description
Interaction-ID: 91295

gene/protein

GLUL

decreases_quantity of

drug/chemical compound

NH3

in muscle
Drugbank entries Show/Hide entries for GLUL
Comment The muscle does not accumulate ammonia produced during the purine nucleotide cycle, instead it releases it in a nontoxic form as glutamine by the action of glutamine synthetase.
Formal Description
Interaction-ID: 91296

gene/protein

GLUL

increases_quantity of

drug/chemical compound

Glutamine

in muscle
Drugbank entries Show/Hide entries for GLUL