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Field	Query

	Field	Term

General Information:

Id:	8,676
Diseases:	Diabetes mellitus, type II - [OMIM]
Organism:	Homo sapiens
Publication type:	article
Reference:	Lee SG et al.(2018) Fasting serum amino acids concentration is associated with insulin resistance and pro-inflammatory cytokines Diabetes Res. Clin. Pract. 140: 107-117 [PMID: 29601913]

Interaction Information:

Comment	Twenty AAs, TNF-alpha, and IL-6 were analyzed in fasting serum samples from a total of 198 individuals (56 drug-naive patients with T2DM, 69 patients IFG (impaired fasting glucose), and 73 healthy controls). In addition to branched chain amino acids BCAAs, fasting serum AAs such as glutamic acid, lysine, phenylalanine, arginine, alanine, tyrosine, aspartic acid, were higher in patients with T2DM and intermediately elevated in patients with IFG compared with normoglycemic controls.
Formal Description Interaction-ID: 90129	disease Diabetes mellitus, type II increases_quantity of drug/chemical compound Glutamate in fasting serum; of patients with T2DM compared to healthy controls

Comment	Twenty AAs, TNF-alpha, and IL-6 were analyzed in fasting serum samples from a total of 198 individuals (56 drug-naive patients with T2DM, 69 patients IFG (impaired fasting glucose), and 73 healthy controls). In addition to branched chain amino acids BCAAs, fasting serum AAs such as glutamic acid, lysine, phenylalanine, arginine, alanine, tyrosine, aspartic acid, were higher in patients with T2DM and intermediately elevated in patients with IFG compared with normoglycemic controls.
Formal Description Interaction-ID: 90131	disease Diabetes mellitus, type II increases_quantity of drug/chemical compound Lysine in fasting serum; of patients with T2DM compared to healthy controls

Comment	Twenty AAs, TNF-alpha, and IL-6 were analyzed in fasting serum samples from a total of 198 individuals (56 drug-naive patients with T2DM, 69 patients IFG (impaired fasting glucose), and 73 healthy controls). In addition to branched chain amino acids BCAAs, fasting serum AAs such as glutamic acid, lysine, phenylalanine, arginine, alanine, tyrosine, aspartic acid, were higher in patients with T2DM and intermediately elevated in patients with IFG compared with normoglycemic controls.
Formal Description Interaction-ID: 90133	disease Diabetes mellitus, type II increases_quantity of drug/chemical compound Phenylalanine in fasting serum; of patients with T2DM compared to healthy controls

Comment	Twenty AAs, TNF-alpha, and IL-6 were analyzed in fasting serum samples from a total of 198 individuals (56 drug-naive patients with T2DM, 69 patients IFG (impaired fasting glucose), and 73 healthy controls). In addition to branched chain amino acids BCAAs, fasting serum AAs such as glutamic acid, lysine, phenylalanine, arginine, alanine, tyrosine, aspartic acid, were higher in patients with T2DM and intermediately elevated in patients with IFG compared with normoglycemic controls.
Formal Description Interaction-ID: 90134	disease Diabetes mellitus, type II increases_quantity of drug/chemical compound Arginine in fasting serum; of patients with T2DM compared to healthy controls

Comment	Twenty AAs, TNF-alpha, and IL-6 were analyzed in fasting serum samples from a total of 198 individuals (56 drug-naive patients with T2DM, 69 patients IFG (impaired fasting glucose), and 73 healthy controls). In addition to branched chain amino acids BCAAs, fasting serum AAs such as glutamic acid, lysine, phenylalanine, arginine, alanine, tyrosine, aspartic acid, were higher in patients with T2DM and intermediately elevated in patients with IFG compared with normoglycemic controls.
Formal Description Interaction-ID: 90135	disease Diabetes mellitus, type II increases_quantity of drug/chemical compound Alanine in fasting serum; of patients with T2DM compared to healthy controls

Comment	Twenty AAs, TNF-alpha, and IL-6 were analyzed in fasting serum samples from a total of 198 individuals (56 drug-naive patients with T2DM, 69 patients IFG (impaired fasting glucose), and 73 healthy controls). In addition to branched chain amino acids BCAAs, fasting serum AAs such as glutamic acid, lysine, phenylalanine, arginine, alanine, tyrosine, aspartic acid, were higher in patients with T2DM and intermediately elevated in patients with IFG compared with normoglycemic controls.
Formal Description Interaction-ID: 90136	disease Diabetes mellitus, type II increases_quantity of drug/chemical compound Tyrosine in fasting serum; of patients with T2DM compared to healthy controls

Comment	Twenty AAs, TNF-alpha, and IL-6 were analyzed in fasting serum samples from a total of 198 individuals (56 drug-naive patients with T2DM, 69 patients IFG (impaired fasting glucose), and 73 healthy controls). In addition to branched chain amino acids BCAAs, fasting serum AAs such as glutamic acid, lysine, phenylalanine, arginine, alanine, tyrosine, aspartic acid, were higher in patients with T2DM and intermediately elevated in patients with IFG compared with normoglycemic controls.
Formal Description Interaction-ID: 90137	disease Diabetes mellitus, type II increases_quantity of drug/chemical compound Aspartate in fasting serum; of patients with T2DM compared to healthy controls

Comment	Twenty AAs, TNF-alpha, and IL-6 were analyzed in fasting serum samples from a total of 198 individuals (56 drug-naive patients with T2DM, 69 patients IFG (impaired fasting glucose), and 73 healthy controls). In addition to branched chain amino acids BCAAs, fasting serum AAs such as glutamic acid, lysine, phenylalanine, arginine, alanine, tyrosine, aspartic acid, were higher in patients with T2DM and intermediately elevated in patients with IFG compared with normoglycemic controls.
Formal Description Interaction-ID: 90138	phenotype hyperglycemia increases_quantity of drug/chemical compound Glutamate in fasting serum; of patients with IFG compared to healthy controls

Comment	Twenty AAs, TNF-alpha, and IL-6 were analyzed in fasting serum samples from a total of 198 individuals (56 drug-naive patients with T2DM, 69 patients IFG (impaired fasting glucose), and 73 healthy controls). In addition to branched chain amino acids BCAAs, fasting serum AAs such as glutamic acid, lysine, phenylalanine, arginine, alanine, tyrosine, aspartic acid, were higher in patients with T2DM and intermediately elevated in patients with IFG compared with normoglycemic controls.
Formal Description Interaction-ID: 90139	phenotype hyperglycemia increases_quantity of drug/chemical compound Lysine in fasting serum; of patients with IFG compared to healthy controls

Comment	Twenty AAs, TNF-alpha, and IL-6 were analyzed in fasting serum samples from a total of 198 individuals (56 drug-naive patients with T2DM, 69 patients IFG (impaired fasting glucose), and 73 healthy controls). In addition to branched chain amino acids BCAAs, fasting serum AAs such as glutamic acid, lysine, phenylalanine, arginine, alanine, tyrosine, aspartic acid, were higher in patients with T2DM and intermediately elevated in patients with IFG compared with normoglycemic controls.
Formal Description Interaction-ID: 90140	phenotype hyperglycemia increases_quantity of drug/chemical compound Phenylalanine in fasting serum; of patients with IFG compared to healthy controls

Comment	Twenty AAs, TNF-alpha, and IL-6 were analyzed in fasting serum samples from a total of 198 individuals (56 drug-naive patients with T2DM, 69 patients IFG (impaired fasting glucose), and 73 healthy controls). In addition to branched chain amino acids BCAAs, fasting serum AAs such as glutamic acid, lysine, phenylalanine, arginine, alanine, tyrosine, aspartic acid, were higher in patients with T2DM and intermediately elevated in patients with IFG compared with normoglycemic controls.
Formal Description Interaction-ID: 90141	phenotype hyperglycemia increases_quantity of drug/chemical compound Arginine in fasting serum; of patients with IFG compared to healthy controls

Comment	Twenty AAs, TNF-alpha, and IL-6 were analyzed in fasting serum samples from a total of 198 individuals (56 drug-naive patients with T2DM, 69 patients IFG (impaired fasting glucose), and 73 healthy controls). In addition to branched chain amino acids BCAAs, fasting serum AAs such as glutamic acid, lysine, phenylalanine, arginine, alanine, tyrosine, aspartic acid, were higher in patients with T2DM and intermediately elevated in patients with IFG compared with normoglycemic controls.
Formal Description Interaction-ID: 90142	phenotype hyperglycemia increases_quantity of drug/chemical compound Alanine in fasting serum; of patients with IFG compared to healthy controls

Comment	Twenty AAs, TNF-alpha, and IL-6 were analyzed in fasting serum samples from a total of 198 individuals (56 drug-naive patients with T2DM, 69 patients IFG (impaired fasting glucose), and 73 healthy controls). In addition to branched chain amino acids BCAAs, fasting serum AAs such as glutamic acid, lysine, phenylalanine, arginine, alanine, tyrosine, aspartic acid, were higher in patients with T2DM and intermediately elevated in patients with IFG compared with normoglycemic controls.
Formal Description Interaction-ID: 90143	phenotype hyperglycemia increases_quantity of drug/chemical compound Tyrosine in fasting serum; of patients with IFG compared to healthy controls

Comment	Twenty AAs, TNF-alpha, and IL-6 were analyzed in fasting serum samples from a total of 198 individuals (56 drug-na√Įve patients with T2DM, 69 patients IFG (impaired fasting glucose), and 73 healthy controls). In addition to branched chain amino acids BCAAs, fasting serum AAs such as glutamic acid, lysine, phenylalanine, arginine, alanine, tyrosine, aspartic acid, were higher in patients with T2DM and intermediately elevated in patients with IFG compared with normoglycemic controls.
Formal Description Interaction-ID: 90144	phenotype hyperglycemia increases_quantity of drug/chemical compound Aspartate in fasting serum; of patients with IFG compared to healthy controls

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