CIDeRplusGeneral Information:
| Id: | 8,674 |
| Diseases: |
Metabolic
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| Rattus norvegicus | |
| article/cited | |
| Reference: | [PMID: 7395984] |
Interaction Information:
| Comment | Adenosine 5'-monophosphate (AMP) deaminase, an enzyme of the IMP salvage pathway, catalyzes the irreversible deamination of AMP to IMP and ammonia. IMP may be reaminated to AMP by adenylosuccinate synthetase (catalyzing the reaction IMP+aspartate+GTP to adenylosuccinate+GDP+phosphate) and adenylosuccinate lyase (catalyzing the reaction adenylosuccinate to AMP+fumarate). (cited information) |
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Formal Description Interaction-ID: 90079 |
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| Comment | Adenosine 5'-monophosphate (AMP) deaminase, an enzyme of the IMP salvage pathway, catalyzes the irreversible deamination of AMP to IMP and ammonia. IMP may be reaminated to AMP by adenylosuccinate synthetase (catalyzing the reaction IMP+aspartate+GTP to adenylosuccinate+GDP+phosphate) and adenylosuccinate lyase (catalyzing the reaction adenylosuccinate to AMP+fumarate). (cited information) |
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Formal Description Interaction-ID: 90080 |
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| Comment | Adenosine 5'-monophosphate (AMP) deaminase, an enzyme of the IMP salvage pathway, catalyzes the irreversible deamination of AMP to IMP and ammonia. IMP may be reaminated to AMP by adenylosuccinate synthetase (catalyzing the reaction IMP+aspartate+GTP to adenylosuccinate+GDP+phosphate) and adenylosuccinate lyase (catalyzing the reaction adenylosuccinate to AMP+fumarate). (cited information) |
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Formal Description Interaction-ID: 90081 |
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| Comment | Adenosine 5'-monophosphate (AMP) deaminase, an enzyme of the IMP salvage pathway, catalyzes the irreversible deamination of AMP to IMP and ammonia. IMP may be reaminated to AMP by adenylosuccinate synthetase (catalyzing the reaction IMP+aspartate+GTP to adenylosuccinate+GDP+phosphate) and adenylosuccinate lyase (catalyzing the reaction adenylosuccinate to AMP+fumarate). (cited information) |
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Formal Description Interaction-ID: 90189 |
gene/protein Adenylosuccinate synthetase increases_quantity of drug/chemical compound |
| Comment | Adenosine 5'-monophosphate (AMP) deaminase, an enzyme of the IMP salvage pathway, catalyzes the irreversible deamination of AMP to IMP and ammonia. IMP may be reaminated to AMP by adenylosuccinate synthetase (catalyzing the reaction IMP+aspartate+GTP to adenylosuccinate+GDP+phosphate) and adenylosuccinate lyase (catalyzing the reaction adenylosuccinate to AMP+fumarate). (cited information) |
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Formal Description Interaction-ID: 90190 |
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| Comment | Adenosine 5'-monophosphate (AMP) deaminase, an enzyme of the IMP salvage pathway, catalyzes the irreversible deamination of AMP to IMP and ammonia. IMP may be reaminated to AMP by adenylosuccinate synthetase (catalyzing the reaction IMP+aspartate+GTP to adenylosuccinate+GDP+phosphate) and adenylosuccinate lyase (catalyzing the reaction adenylosuccinate to AMP+fumarate). (cited information) |
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Formal Description Interaction-ID: 90194 |
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| Comment | Adenosine 5'-monophosphate (AMP) deaminase, an enzyme of the IMP salvage pathway, catalyzes the irreversible deamination of AMP to IMP and ammonia. IMP may be reaminated to AMP by adenylosuccinate synthetase (catalyzing the reaction IMP+aspartate+GTP to adenylosuccinate+GDP+phosphate) and adenylosuccinate lyase (catalyzing the reaction adenylosuccinate to AMP+fumarate). (cited information) |
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Formal Description Interaction-ID: 90195 |
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| Comment | Adenosine 5'-monophosphate (AMP) deaminase, an enzyme of the IMP salvage pathway, catalyzes the irreversible deamination of AMP to IMP and ammonia. IMP may be reaminated to AMP by adenylosuccinate synthetase (catalyzing the reaction IMP+aspartate+GTP to adenylosuccinate+GDP+phosphate) and adenylosuccinate lyase (catalyzing the reaction adenylosuccinate to AMP+fumarate). (cited information) |
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Formal Description Interaction-ID: 90196 |
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| Comment | Adenosine 5'-monophosphate (AMP) deaminase, an enzyme of the IMP salvage pathway, catalyzes the irreversible deamination of AMP to IMP and ammonia. IMP may be reaminated to AMP by adenylosuccinate synthetase (catalyzing the reaction IMP+aspartate+GTP to adenylosuccinate+GDP+phosphate) and adenylosuccinate lyase (catalyzing the reaction adenylosuccinate to AMP+fumarate). (cited information) |
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Formal Description Interaction-ID: 90200 |
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| Drugbank entries | Show/Hide entries for |
| Comment | Adenosine 5'-monophosphate (AMP) deaminase, an enzyme of the IMP salvage pathway, catalyzes the irreversible deamination of AMP to IMP and ammonia. IMP may be reaminated to AMP by adenylosuccinate synthetase (catalyzing the reaction IMP+aspartate+GTP to adenylosuccinate+GDP+phosphate) and adenylosuccinate lyase (catalyzing the reaction adenylosuccinate to AMP+fumarate). (cited information) |
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Formal Description Interaction-ID: 90201 |
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| Comment | Fumarate produced during reamination of IMP to AMP catalyzed by ADSL, could supply 4-carbon intermediates to support the Krebs cycle during accelerated aerobic metabolism. (cited information) |
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Formal Description Interaction-ID: 90203 |
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| Drugbank entries | Show/Hide entries for Fumarate |
| Comment | AMP deaminase is activated by accumulation of ADP, AMP or by decreasing pH. |
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Formal Description Interaction-ID: 90205 |
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| Comment | AMP deaminase is activated by accumulation of ADP, AMP or by decreasing pH. |
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Formal Description Interaction-ID: 90206 |
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| Comment | AMP deaminase is activated by accumulation of ADP, AMP or by decreasing pH. |
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Formal Description Interaction-ID: 90207 |
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| Comment | Hadacidin is a competitive inhibitor of aspartate binding to adenylosuccinate synthetase, thereby inhibiting IMP reamination. |
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Formal Description Interaction-ID: 90208 |
drug/chemical compound Hadacidin decreases_activity of gene/protein Adenylosuccinate synthetase |
| Drugbank entries | Show/Hide entries for Hadacidin |
| Comment | Adenylosuccinate synthetase activity is inhibited by GDP, ADP, AMP, and IMP. |
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Formal Description Interaction-ID: 90210 |
drug/chemical compound decreases_activity of gene/protein Adenylosuccinate synthetase |
| Comment | Adenylosuccinate synthetase activity is inhibited by GDP, ADP, AMP, and IMP. |
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Formal Description Interaction-ID: 90211 |
drug/chemical compound decreases_activity of gene/protein Adenylosuccinate synthetase |
| Comment | Adenylosuccinate synthetase activity is inhibited by GDP, ADP, AMP, and IMP. |
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Formal Description Interaction-ID: 90212 |
drug/chemical compound decreases_activity of gene/protein Adenylosuccinate synthetase |
| Comment | Adenylosuccinate synthetase activity is inhibited by GDP, ADP, AMP, and IMP. |
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Formal Description Interaction-ID: 90213 |
drug/chemical compound decreases_activity of gene/protein Adenylosuccinate synthetase |
| Comment | AMP deaminase is inhibited under resting conditions. |
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Formal Description Interaction-ID: 90221 |
environment resting condition decreases_activity of gene/protein AMP deaminase |
| Comment | Gastrocnemius and plantaris muscles were stimulated tetanically for 3 min and allowed to recover in situ for 30 min. This intense stimulation results in conversion of about half the total adenine nucleotide pool (chiefly ATP) to IMP, which is subsequently reaminated during the recovery period. The concentration of ammonia and lactate increases as well. IMP and ammonia accumulate under rigorous tetanic contractions. |
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Formal Description Interaction-ID: 90227 |
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| Comment | Gastrocnemius and plantaris muscles were stimulated tetanically for 3 min and allowed to recover in situ for 30 min. This intense stimulation results in conversion of about half the total adenine nucleotide pool (chiefly ATP) to IMP, which is subsequently reaminated during the recovery period. IMP and ammonia accumulate under rigorous tetanic contractions. The concentration of ammonia and lactate increases as well. |
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Formal Description Interaction-ID: 90229 |
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| Comment | Gastrocnemius and plantaris muscles were stimulated tetanically for 3 min and allowed to recover in situ for 30 min. This intense stimulation results in conversion of about half the total adenine nucleotide pool (chiefly ATP) to IMP, which is subsequently reaminated during the recovery period. IMP and ammonia accumulate under rigorous tetanic contractions. The concentration of ammonia and lactate increases as well. |
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Formal Description Interaction-ID: 90231 |
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| Comment | Gastrocnemius and plantaris muscles were stimulated tetanically for 3 min and allowed to recover in situ for 30 min. This intense stimulation results in conversion of about half the total adenine nucleotide pool (chiefly ATP) to IMP, which is subsequently reaminated during the recovery period. IMP and ammonia accumulate under rigorous tetanic contractions. The concentration of ammonia and lactate increases as well. |
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Formal Description Interaction-ID: 90232 |
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| Comment | The level of AMP deaminase is much higher in fast muscles than the level of the other two enzymes of the purine nucleotide pathway, adenylosuccinate synthetase and adenylosuccinate lyase. This suggests that the rate of IMP reamination might be negligible relative to the rate of IMP formation during intense stimulation. |
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Formal Description Interaction-ID: 90234 |
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| Comment | The level of AMP deaminase is much higher in fast muscles than the level of the other two enzymes of the purine nucleotide pathway, adenylosuccinate synthetase and adenylosuccinate lyase. This suggests that the rate of IMP reamination might be negligible relative to the rate of IMP formation during intense stimulation. |
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Formal Description Interaction-ID: 90237 |
process decreases_activity of gene/protein Adenylosuccinate synthetase |
| Comment | The level of AMP deaminase is much higher in fast muscles than the level of the other two enzymes of the purine nucleotide pathway, adenylosuccinate synthetase and adenylosuccinate lyase. This suggests that the rate of IMP reamination might be negligible relative to the rate of IMP formation during intense stimulation. |
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Formal Description Interaction-ID: 90238 |
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| Comment | AMP deaminase is activated by ADP and AMP and inhibited by GTP and phosphate. This explains, why AMP deamination occurs to a significant extent in fast muscle only when the capacity for generation of ATP by aerobic metabolism is exceeded by the rate of ATP utlization. (cited information) |
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Formal Description Interaction-ID: 90307 |
drug/chemical compound decreases_activity of gene/protein AMP deaminase |
| Comment | AMP deaminase is activated by ADP and AMP and inhibited by GTP and phosphate. This explains, why AMP deamination occurs to a significant extent in fast muscle only when the capacity for generation of ATP by aerobic metabolism is exceeded by the rate of ATP utlization. (cited information) |
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Formal Description Interaction-ID: 90310 |
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| Comment | Lactate accumulation due to intense muscle work might result in a decrease of intracellular pH. Low pH contributes to the activation of AMP deaminase. (cited information) |
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Formal Description Interaction-ID: 90312 |
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| Comment | AMP deamination may also contribute to the control of glycolysis in fast muscle by supplying ammonium ion, an activator of phosphofructokinase. (cited information) |
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Formal Description Interaction-ID: 90313 |
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| Comment | AMP deamination may also contribute to the control of glycolysis in fast muscle by supplying ammonium ion, an activator of phosphofructokinase. (cited information) |
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Formal Description Interaction-ID: 90316 |
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| Comment | Adenosine 5'-monophosphate (AMP) deaminase, an enzyme of the IMP salvage pathway, catalyzes the irreversible deamination of AMP to IMP and ammonia. IMP may be reaminated to AMP by adenylosuccinate synthetase (catalyzing the reaction IMP+aspartate+GTP to adenylosuccinate+GDP+phosphate) and adenylosuccinate lyase (catalyzing the reaction adenylosuccinate to AMP+fumarate). (cited information) |
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Formal Description Interaction-ID: 90352 |
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| Comment | Adenosine 5'-monophosphate (AMP) deaminase, an enzyme of the IMP salvage pathway, catalyzes the irreversible deamination of AMP to IMP and ammonia. IMP may be reaminated to AMP by adenylosuccinate synthetase (catalyzing the reaction IMP+aspartate+GTP to adenylosuccinate+GDP+phosphate) and adenylosuccinate lyase (catalyzing the reaction adenylosuccinate to AMP+fumarate). (cited information) |
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Formal Description Interaction-ID: 90353 |
drug/chemical compound increases_quantity of drug/chemical compound |
| Comment | Adenosine 5'-monophosphate (AMP) deaminase, an enzyme of the IMP salvage pathway, catalyzes the irreversible deamination of AMP to IMP and ammonia. IMP may be reaminated to AMP by adenylosuccinate synthetase (catalyzing the reaction IMP+aspartate+GTP to adenylosuccinate+GDP+phosphate) and adenylosuccinate lyase (catalyzing the reaction adenylosuccinate to AMP+fumarate). (cited information) |
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Formal Description Interaction-ID: 90354 |
drug/chemical compound increases_quantity of drug/chemical compound |
| Comment | AMP deamination may also contribute to the control of glycolysis in fast muscle by supplying ammonium ion, an activator of phosphofructokinase. (cited information) |
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Formal Description Interaction-ID: 91239 |
gene/protein Phosphofructokinase increases_activity of process |
| Comment | AMP deamination may also contribute to the control of glycolysis in fast muscle by supplying ammonium ion, an activator of phosphofructokinase. (cited information) |
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Formal Description Interaction-ID: 91240 |
drug/chemical compound increases_activity of gene/protein Phosphofructokinase |
| Comment | Adenosine 5'-monophosphate (AMP) deaminase, an enzyme of the IMP salvage pathway, catalyzes the irreversible deamination of AMP to IMP and ammonia. IMP may be reaminated to AMP by adenylosuccinate synthetase (catalyzing the reaction IMP+aspartate+GTP to adenylosuccinate+GDP+phosphate) and adenylosuccinate lyase (catalyzing the reaction adenylosuccinate to AMP+fumarate). (cited information) |
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Formal Description Interaction-ID: 91574 |
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| Drugbank entries | Show/Hide entries for |