General Information:

Id: 8,655
Diseases: Metabolic
Homo sapiens
article
Reference: Kaya M et al.(2006) Plasma concentrations and urinary excretion of purine bases (uric acid, hypoxanthine, and xanthine) and oxypurinol after rigorous exercise Metab. Clin. Exp. 55: 103-107 [PMID: 16324927]

Interaction Information:

Comment To investigate the effects of exercise on the plasma concentrations and urinary excretion of purine bases(hypoxanthine, xanthine) and oxypurinol, 3 experiments were performed with 6 healthy male subjects. The first was a combination of allopurinol intake (300 mg) and exercise (VO2max, 70%) (combination experiment), the second was exercise alone (exercise-alone experiment), and the third was allopurinol intake alone (allopurinol-alone experiment). In the exercise-alone experiment, exercise increased the concentrations of purine bases and noradrenaline in plasma, lactic acid in blood.
Formal Description
Interaction-ID: 89697

environment

rigorous exercise

increases_quantity of

drug/chemical compound

Hypoxanthine

in plasma; of health male subjects in exercise-alone experiment in period 2, as compared with those values at period 1
Drugbank entries Show/Hide entries for
Comment To investigate the effects of exercise on the plasma concentrations and urinary excretion of purine bases(hypoxanthine, xanthine) and oxypurinol, 3 experiments were performed with 6 healthy male subjects. The first was a combination of allopurinol intake (300 mg) and exercise (VO2max, 70%) (combination experiment), the second was exercise alone (exercise-alone experiment), and the third was allopurinol intake alone (allopurinol-alone experiment). In the exercise-alone experiment, exercise increased the concentrations of purine bases and noradrenaline in plasma, lactic acid in blood.
Formal Description
Interaction-ID: 90936

environment

rigorous exercise

increases_quantity of

drug/chemical compound

Xanthine

in plasma; of healthy male subjects in exercise-alone experiment in period 2, as compared with those values at period 1
Drugbank entries Show/Hide entries for
Comment To investigate the effects of exercise on the plasma concentrations and urinary excretion of purine bases(hypoxanthine, xanthine) and oxypurinol, 3 experiments were performed with 6 healthy male subjects. The first was a combination of allopurinol intake (300 mg) and exercise (VO2max, 70%) (combination experiment), the second was exercise alone (exercise-alone experiment), and the third was allopurinol intake alone (allopurinol-alone experiment). In the exercise-alone experiment, exercise increased the concentrations of purine bases and noradrenaline in plasma, lactic acid in blood.
Formal Description
Interaction-ID: 90938

environment

rigorous exercise

increases_quantity of

drug/chemical compound

Noradrenaline

in plasma; of healthy male subjects in exercise-alone experiment
Comment To investigate the effects of exercise on the plasma concentrations and urinary excretion of purine bases(hypoxanthine, xanthine) and oxypurinol, 3 experiments were performed with 6 healthy male subjects. The first was a combination of allopurinol intake (300 mg) and exercise (VO2max, 70%) (combination experiment), the second was exercise alone (exercise-alone experiment), and the third was allopurinol intake alone (allopurinol-alone experiment). In the exercise-alone experiment, exercise increased the concentrations of purine bases and noradrenaline in plasma, lactic acid in blood.
Formal Description
Interaction-ID: 90939

environment

rigorous exercise

increases_quantity of

drug/chemical compound

Lactate

in blood; of healthy male subjects in exercise-alone experiment