CIDeRplusGeneral Information:
| Id: | 8,640 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Newsholme P and Krause M(2012) Nutritional regulation of insulin secretion: implications for diabetes Clin Biochem Rev 33: 35-47 [PMID: 22896743] |
Interaction Information:
| Comment | L-glutamine is rapidly taken up and metabolised by islets, however, alone it does not stimulate insulin secretion or enhance glucose-induced insulin secretion. Activation of glutamate dehydrogenase (GDH) by addition of leucine enhances insulin secretion by increasing the entry of glutamine carbon into the tricarboxylic acid cycle. The production of gamma-aminobutyric acid (GABA) from glutamine has been proposed as an explanation for the paradox that glutamine alone does not stimulate insulin release. Under this scheme, glutamine is preferentially metabolised to GABA and L-aspartate. There is no oxidation of glutamine in the process and thus stimulus-secretion coupling via ATP would be minimal. |
|
Formal Description Interaction-ID: 90790 |
|