CIDeRplusGeneral Information:
| Id: | 8,638 |
| Diseases: |
Cancer
Diabetes mellitus, type II - [OMIM] Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Bi X and Henry CJ(2017) Plasma-free amino acid profiles are predictors of cancer and diabetes development Nutr Diabetes 7: e249 [PMID: 28287627] |
Interaction Information:
| Comment | Insulin has long been recognized as the regulator of branched-chain alpha-keto acid dehydrogenase complex, an enzyme complex involved in BCAA catabolism. Insulin resistance has been found to reduce the enzymatic activity of branched-chain alpha-keto acid dehydrogenase complex and hence suppress BCAA catabolism. This is considered as the plausible etiology of increased BCAA levels in obesity and/or diabetes. Indeed, evidence is accumulating that there is positive association between insulin resistance and circulating concentrations of BCAAs. |
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Formal Description Interaction-ID: 89358 |
complex/PPI Insulin affects_activity of complex/PPI Branched-chain keto acid dehydrogenase complex |
| Comment | Insulin has long been recognized as the regulator of branched-chain alpha-keto acid dehydrogenase complex, an enzyme complex involved in BCAA catabolism. Insulin resistance has been found to reduce the enzymatic activity of branched-chain alpha-keto acid dehydrogenase complex and hence suppress BCAA catabolism. This is considered as the plausible etiology of increased BCAA levels in obesity and/or diabetes. Indeed, evidence is accumulating that there is positive association between insulin resistance and circulating concentrations of BCAAs. |
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Formal Description Interaction-ID: 89712 |
disease Insulin resistance decreases_activity of complex/PPI Branched-chain keto acid dehydrogenase complex |
| Comment | Insulin resistance was shown to be correlated with the alterations of several other PFAAs, including aromatic amino acids (AAAs), alanine (Ala), proline (Pro) and glycine (Gly). |
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Formal Description Interaction-ID: 89713 |
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| Comment | Insulin resistance was shown to be correlated with the alterations of several other PFAAs, including aromatic amino acids (AAAs), alanine (Ala), proline (Pro) and glycine (Gly). |
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Formal Description Interaction-ID: 89714 |
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| Comment | Insulin resistance was shown to be correlated with the alterations of several other PFAAs, including aromatic amino acids (AAAs), alanine (Ala), proline (Pro) and glycine (Gly). |
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Formal Description Interaction-ID: 89715 |
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| Comment | Insulin resistance was shown to be correlated with the alterations of several other PFAAs, including aromatic amino acids (AAAs), alanine (Ala), proline (Pro) and glycine (Gly). |
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Formal Description Interaction-ID: 89716 |
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| Drugbank entries | Show/Hide entries for |
| Comment | Cancer cells require certain amino acids, for example, glutamine (Gln), Gly, aspartic acid (Asp) and serine (Ser), for DNA synthesis, building new blood vessels, and duplicating their entire protein contents. They also require amino acids for proteins synthesis. |
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Formal Description Interaction-ID: 89717 |
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| Comment | Cancer cells require certain amino acids, for example, glutamine (Gln), Gly, aspartic acid (Asp) and serine (Ser), for DNA synthesis, building new blood vessels, and duplicating their entire protein contents. They also require amino acids for proteins synthesis. |
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Formal Description Interaction-ID: 89718 |
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| Drugbank entries | Show/Hide entries for Glycine |
| Comment | Cancer cells require certain amino acids, for example, glutamine (Gln), Gly, aspartic acid (Asp) and serine (Ser), for DNA synthesis, building new blood vessels, and duplicating their entire protein contents. They also require amino acids for proteins synthesis. |
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Formal Description Interaction-ID: 89719 |
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| Comment | Cancer cells require certain amino acids, for example, glutamine (Gln), Gly, aspartic acid (Asp) and serine (Ser), for DNA synthesis, building new blood vessels, and duplicating their entire protein contents. They also require amino acids for proteins synthesis. |
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Formal Description Interaction-ID: 89720 |
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| Comment | The elevated BCAAs are able to activate mTORC and its downstream effecter S6K1 in the liver, muscle and adipose tissue. Persistent activation leads to serine phosphorylation of IRS-1 and thus the inhibition of IRS-1, resulting in insulin resistance. |
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Formal Description Interaction-ID: 89721 |
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| Comment | The elevated BCAAs are able to activate mTORC and its downstream effecter S6K1 in the liver, muscle and adipose tissue. Persistent activation leads to serine phosphorylation of IRS-1 and thus the inhibition of IRS-1, resulting in insulin resistance. |
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Formal Description Interaction-ID: 89722 |
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| Comment | The elevated BCAAs are able to activate mTORC and its downstream effecter S6K1 in the liver, muscle and adipose tissue. Persistent activation leads to serine phosphorylation of IRS-1 and thus the inhibition of IRS-1, resulting in insulin resistance. |
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Formal Description Interaction-ID: 89723 |
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| Drugbank entries | Show/Hide entries for IRS1 |
| Comment | Aromatic amino acids (AAAs) are metabolized to catecholamines, which alter the liver function leading to hyperinsulinemia and dyslipidemia. |
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Formal Description Interaction-ID: 89724 |
drug/chemical compound increases_activity of |
| Comment | Aromatic amino acids (AAAs) are metabolized to catecholamines, which alter the liver function leading to hyperinsulinemia and dyslipidemia. |
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Formal Description Interaction-ID: 89725 |
drug/chemical compound increases_quantity of drug/chemical compound |
| Comment | Alanine is metabolized to pyruvate to maintain glucose homeostasis. |
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Formal Description Interaction-ID: 89726 |
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| Comment | Alanine is metabolized to pyruvate to maintain glucose homeostasis. |
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Formal Description Interaction-ID: 89727 |
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