General Information:

Id: 861 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
brain
article
Reference: Pei JJ et al.(2003) Role of protein kinase B in Alzheimers neurofibrillary pathology. Acta Neuropathol. 105: 381-392 [PMID: 12624792]

Interaction Information:

Comment Protein kinase B (PKB) is an important intermediate in the phosphatidylinositol-3 kinase signaling cascade that acts to phosphorylate glycogen synthase kinase-3 (GSK-3) at its serine 9 residue, thereby inactivating it.
Formal Description
Interaction-ID: 5106

gene/protein

AKT1

increases_phosphorylation of

gene/protein

GSK3B

at Ser9, thereby inactivating GSK3B;
Drugbank entries Show/Hide entries for AKT1 or GSK3B
Comment PKB was increased in AD brains as compared with normal aged and Huntington's disease controls.
Formal Description
Interaction-ID: 5108

disease

Alzheimer disease

increases_quantity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment Protein kinase B (PKB) is an important intermediate in the phosphatidylinositol-3 kinase signaling cascade that acts to phosphorylate glycogen synthase kinase-3 (GSK-3) at its serine 9 residue, thereby inactivating it.
Formal Description
Interaction-ID: 5117

gene/protein

AKT1

affects_phosphorylation of

gene/protein

GSK3

at Ser9; this phosphorylated GSK3 is inactivated
Drugbank entries Show/Hide entries for AKT1
Comment Both active PKB and GSK-3alpha/beta preceded the abnormal hyperphosphorylation of tau in pattern 1 neurons.
Formal Description
Interaction-ID: 5119

gene/protein

AKT1

increases_quantity of

protein modification

MAPT-hyperphos

Drugbank entries Show/Hide entries for AKT1
Comment In the protein kinase B signaling cascade (=Akt signaling pathway) AKT1 acts as key enzyme.
Formal Description
Interaction-ID: 19094

gene/protein

AKT1

affects_activity of

process

protein kinase B signaling

Drugbank entries Show/Hide entries for AKT1