CIDeRplusGeneral Information:
| Id: | 8,614 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| article | |
| Reference: | Fujisaka S et al.(2018) Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites Cell Rep 22: 3072-3086 [PMID: 29539432] |
Interaction Information:
| Comment | Some changes depended on the strain or breeding site of the mouse and the resulting differences in bacterial composition. For example, both antibiotics elevated allantoin in the cecum but had a reverse effect in the plasma uniquely in Jax-bred mice. Likewise, both B6J and 129J mice showed a marked decrease in cecal gamma-aminobutyric acid (GABA) levels in response to vancomycin and an increase by metronidazole, which was not seen in 129T mice. Both B6J and 129J mice also showed an increase in cecal threonine by vancomycin and a decrease by metronidazole, which was not observed in 129T mice. On the other hand, antibiotic treatment of HFD-fed mice produced a decrease in asparagine in only 129T Tac-derived mice. None of the latter changes were observed in the plasma, suggesting that gut bacterial metabolism is not the primary driver controlling the plasma levels of these metabolites. Hexose (fructose/glucose/galactose) levels in the cecum were decreased by an HFD and partially rescued by vancomycin in B6J and 129J mice but not in 129T mice; however, smaller changes were observed in plasma levels. |
|
Formal Description Interaction-ID: 89091 |
environment antibiotic intake affects_quantity of drug/chemical compound |