General Information:
Id: | 861 |
Diseases: |
Alzheimer disease
- [OMIM]
|
Homo sapiens | |
brain | |
article | |
Reference: | Pei JJ et al.(2003) Role of protein kinase B in Alzheimers neurofibrillary pathology. Acta Neuropathol. 105: 381-392 [PMID: 12624792] |
Interaction Information:
Comment | Protein kinase B (PKB) is an important intermediate in the phosphatidylinositol-3 kinase signaling cascade that acts to phosphorylate glycogen synthase kinase-3 (GSK-3) at its serine 9 residue, thereby inactivating it. |
Formal Description Interaction-ID: 5106 |
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Drugbank entries | Show/Hide entries for AKT1 or GSK3B |
Comment | PKB was increased in AD brains as compared with normal aged and Huntington's disease controls. |
Formal Description Interaction-ID: 5108 |
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Drugbank entries | Show/Hide entries for AKT1 |
Comment | This increase in PKB levels corresponded with a several-fold increase in the levels of total tau and abnormally hyperphosphorylated tau at the Tau-1 site. |
Formal Description Interaction-ID: 5109 |
phenotype increased AKT1 level cooccurs with phenotype increased MAPT level |
Comment | This increase in PKB levels corresponded with a several-fold increase in the levels of total tau and abnormally hyperphosphorylated tau at the Tau-1 site. |
Formal Description Interaction-ID: 5111 |
phenotype increased AKT1 level cooccurs with phenotype increased MAPT-hyperphos level |
Comment | The amount of activated PKB (phos-Thr308) is increased in correlation to the neurofibrillary changes. |
Formal Description Interaction-ID: 5115 |
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Comment | Protein kinase B (PKB) is an important intermediate in the phosphatidylinositol-3 kinase signaling cascade that acts to phosphorylate glycogen synthase kinase-3 (GSK-3) at its serine 9 residue, thereby inactivating it. |
Formal Description Interaction-ID: 5117 |
gene/protein affects_phosphorylation of gene/protein GSK3 |
Drugbank entries | Show/Hide entries for AKT1 |
Comment | Both active PKB and GSK-3alpha/beta preceded the abnormal hyperphosphorylation of tau in pattern 1 neurons. |
Formal Description Interaction-ID: 5119 |
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Drugbank entries | Show/Hide entries for AKT1 |
Comment | In the protein kinase B signaling cascade (=Akt signaling pathway) AKT1 acts as key enzyme. |
Formal Description Interaction-ID: 19094 |
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Drugbank entries | Show/Hide entries for AKT1 |
Comment | Both active PKB and GSK-3alpha/beta preceded the abnormal hyperphosphorylation of tau in pattern 1 neurons. |
Formal Description Interaction-ID: 23597 |
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Drugbank entries | Show/Hide entries for GSK3B |
Comment | Both active PKB and GSK-3alpha/beta preceded the abnormal hyperphosphorylation of tau in pattern 1 neurons. |
Formal Description Interaction-ID: 23598 |
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