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Field	Query

	Field	Term

General Information:

Id:	855
Diseases:	Breast cancer - [OMIM] Parkinson disease
Organism:	Mus musculus
Publication type:	article
Reference:	Kim RH et al.(2005) DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell 7: 263-273 [PMID: 15766664]

Interaction Information:

Comment	DJ-1 rescues PTEN-induced cell death.
Formal Description Interaction-ID: 5085	gene/protein PTEN increases_activity of process neuron death

Comment	DJ-1 rescues PTEN-induced cell death.
Formal Description Interaction-ID: 5086	gene/protein PARK7 decreases_activity of process neuron death induced by PTEN
Drugbank entries	Show/Hide entries for PARK7
Drugbank DB01769	Double Oxidized Cysteine not specified PARK7
Drugbank DB01769	Double Oxidized Cysteine not specified PARK7

Comment	DJ-1 rescues PTEN-induced cell death.
Formal Description Interaction-ID: 5087	gene/protein PARK7 decreases_activity of gene/protein PTEN
Drugbank entries	Show/Hide entries for PARK7
Drugbank DB01769	Double Oxidized Cysteine not specified PARK7
Drugbank DB01769	Double Oxidized Cysteine not specified PARK7

Comment	DJ-1 can transform cells by increasing both cell proliferation and resistance to cell cycle arrest.
Formal Description Interaction-ID: 5096	gene/protein PARK7 decreases_activity of process cell cycle arrest under starvation conditions
Drugbank entries	Show/Hide entries for PARK7
Drugbank DB01769	Double Oxidized Cysteine not specified PARK7
Drugbank DB01769	Double Oxidized Cysteine not specified PARK7

Comment	DJ-1 can transform cells by increasing both cell proliferation and resistance to cell cycle arrest.
Formal Description Interaction-ID: 5097	gene/protein PARK7 increases_activity of process cell population proliferation under starvation conditions
Drugbank entries	Show/Hide entries for PARK7
Drugbank DB01769	Double Oxidized Cysteine not specified PARK7
Drugbank DB01769	Double Oxidized Cysteine not specified PARK7

Comment	DJ-1 plays a role in the pathogenesis of primary breast cancer. DJ-1 may modulate PTEN function such that PKB/Akt becomes hyperphosphorylated and promotes abnormal cell survival.
Formal Description Interaction-ID: 5098	gene/protein PARK7 increases_activity of disease Breast cancer
Drugbank entries	Show/Hide entries for PARK7
Drugbank DB01769	Double Oxidized Cysteine not specified PARK7
Drugbank DB01769	Double Oxidized Cysteine not specified PARK7

Comment	DJ-1 induced high levels of endogenous phosphorylated PKB/AKT.
Formal Description Interaction-ID: 6308	gene/protein PARK7 increases_phosphorylation of gene/protein AKT1
Drugbank entries	Show/Hide entries for PARK7 or AKT1
Drugbank DB01769	Double Oxidized Cysteine not specified PARK7
Drugbank DB01769	Double Oxidized Cysteine not specified PARK7
Drugbank DB00171	Adenosine triphosphate not specified AKT1
Drugbank DB01169	Arsenic trioxide inducer AKT1
Drugbank DB01863	Inositol 1,3,4,5-Tetrakisphosphate not specified AKT1
Drugbank DB07584	N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phe ... not specified AKT1
Drugbank DB07585	5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4 ... not specified AKT1
Drugbank DB00171	Adenosine triphosphate not specified AKT1
Drugbank DB01863	Inositol 1,3,4,5-Tetrakisphosphate not specified AKT1

Comment	DJ-1 induced high levels of endogenous phosphorylated PKB/AKT.
Formal Description Interaction-ID: 6309	gene/protein PARK7 increases_activity of process protein kinase B signaling
Drugbank entries	Show/Hide entries for PARK7
Drugbank DB01769	Double Oxidized Cysteine not specified PARK7
Drugbank DB01769	Double Oxidized Cysteine not specified PARK7

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