CIDeRplusGeneral Information:
| Id: | 851 (click here to show other Interactions for entry) |
| Diseases: |
Parkinson disease
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| Mus musculus | |
| DJ-1-/- or DJ-1+/+ mice | |
| BTO:0004102 cerebral cortical neuron; BTO:0004032 dopaminergic neuron | |
| article | |
| Reference: | Aleyasin H et al.(2010) DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway Proc. Natl. Acad. Sci. U.S.A. 7: 3186-3191 [PMID: 20133695] |
Interaction Information:
| Comment | Phosphorylation of AKT in response to oxidative stress is reduced in the absence of DJ-1 in vitro and in vivo. |
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Formal Description Interaction-ID: 5063 |
process increases_phosphorylation of gene/protein |
| Drugbank entries | Show/Hide entries for AKT1 |
| Comment | Phosphorylation of AKT in response to oxidative stress is reduced in the absence of DJ-1 in vitro and in vivo. |
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Formal Description Interaction-ID: 5065 |
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| Drugbank entries | Show/Hide entries for PARK7 or AKT1 |
| Comment | AKT protects neuronal cells of DJ-1+/+ animals from cell death in response to H2O2. |
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Formal Description Interaction-ID: 5073 |
gene/protein decreases_activity of process |
| Drugbank entries | Show/Hide entries for AKT1 |
| Comment | DJ-1 is necessary for AKT activation and is neuroprotective in response to H2O2. |
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Formal Description Interaction-ID: 5077 |
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| Drugbank entries | Show/Hide entries for PARK7 or AKT1 |
| Comment | H2O2-induced AKT localization to the membrane fraction is greatly decreased in the DJ-1-/- compared with the DJ-1+/+, indicating that DJ-1 modulates AKT translocation to membranous fractions. |
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Formal Description Interaction-ID: 5081 |
gene/protein is localized in cellular component |
| Drugbank entries | Show/Hide entries for AKT1 |
| Comment | Akt1 is the key enzyme of the Akt signaling pathway. |
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Formal Description Interaction-ID: 9725 |
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| Drugbank entries | Show/Hide entries for AKT1 |