General Information:

Id: 851 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
DJ-1-/- or DJ-1+/+ mice
BTO:0004102 cerebral cortical neuron; BTO:0004032 dopaminergic neuron
article
Reference: Aleyasin H et al.(2010) DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway Proc. Natl. Acad. Sci. U.S.A. 7: 3186-3191 [PMID: 20133695]

Interaction Information:

Comment Phosphorylation of AKT in response to oxidative stress is reduced in the absence of DJ-1 in vitro and in vivo.
Formal Description
Interaction-ID: 5063

process

response to oxidative stress

increases_phosphorylation of

gene/protein

AKT1

in the presence of DJ-1
Drugbank entries Show/Hide entries for AKT1