CIDeRplusGeneral Information:
| Id: | 8,384 |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Obesity - [OMIM] |
| Homo sapiens | |
| Hispanic | |
| article | |
| Reference: | Butte NF et al.(2015) Global metabolomic profiling targeting childhood obesity in the Hispanic population Am. J. Clin. Nutr. 102: 256-267 [PMID: 26085512] |
Interaction Information:
| Comment | Branched-chained amino acids (BCAAs) (Leu, Ile, and Val) and their catabolites, propionylcarnitine and butyrylcarnitine, were significantly elevated in obese children. |
|
Formal Description Interaction-ID: 85066 |
|
| Comment | Branched-chained amino acids (BCAAs) (Leu, Ile, and Val) and their catabolites, propionylcarnitine and butyrylcarnitine, were significantly elevated in obese children. |
|
Formal Description Interaction-ID: 85416 |
|
| Comment | Branched-chained amino acids (BCAAs) (Leu, Ile, and Val) and their catabolites, propionylcarnitine and butyrylcarnitine, were significantly elevated in obese children. |
|
Formal Description Interaction-ID: 85417 |
disease increases_quantity of drug/chemical compound |
| Comment | Branched-chained amino acids (BCAAs) (Leu, Ile, and Val) and their catabolites, propionylcarnitine and butyrylcarnitine, were significantly elevated in obese children. |
|
Formal Description Interaction-ID: 85418 |
disease increases_quantity of drug/chemical compound |
| Comment | Branched-chained amino acids (BCAAs) (Leu, Ile, and Val) and their catabolites, propionylcarnitine and butyrylcarnitine, were significantly elevated in obese children. |
|
Formal Description Interaction-ID: 85419 |
disease increases_quantity of drug/chemical compound |
| Comment | Fasting insulin concentrations and HOMA-IR were elevated in obese children. |
|
Formal Description Interaction-ID: 85421 |
|
| Comment | When adjusted for sex, age, and Tanner stage, BCAAs (Leu, Ile, and Val) were significantly higher in obese children as were BCAA catabolites 2-methylbutyrylcarnitine, 3-methyl-2-oxobutyrate, and isovalerylcarnitine. |
|
Formal Description Interaction-ID: 85436 |
disease increases_quantity of drug/chemical compound Alpha-methylbutyrylcarnitine |
| Comment | When adjusted for sex, age, and Tanner stage, BCAAs (Leu, Ile, and Val) were significantly higher in obese children as were BCAA catabolites 2-methylbutyrylcarnitine, 3-methyl-2-oxobutyrate, and isovalerylcarnitine. |
|
Formal Description Interaction-ID: 85437 |
disease increases_quantity of drug/chemical compound |
| Comment | When adjusted for sex, age, and Tanner stage, BCAAs (Leu, Ile, and Val) were significantly higher in obese children as were BCAA catabolites 2-methylbutyrylcarnitine, 3-methyl-2-oxobutyrate, and isovalerylcarnitine. |
|
Formal Description Interaction-ID: 85438 |
disease increases_quantity of drug/chemical compound Isovalerylcarnitine |
| Comment | Additional AAs (alanine, glutamate, lysine, phenylalanine, and tyrosine), polyamines, several gamma-glutamyl dipeptides, and polypeptides were also elevated in obese children. |
|
Formal Description Interaction-ID: 85439 |
|
| Comment | Additional AAs (alanine, glutamate, lysine, phenylalanine, and tyrosine), polyamines, several gamma-glutamyl dipeptides, and polypeptides were also elevated in obese children. |
|
Formal Description Interaction-ID: 85440 |
|
| Comment | Additional AAs (alanine, glutamate, lysine, phenylalanine, and tyrosine), polyamines, several gamma-glutamyl dipeptides, and polypeptides were also elevated in obese children. |
|
Formal Description Interaction-ID: 85441 |
|
| Comment | Additional AAs (alanine, glutamate, lysine, phenylalanine, and tyrosine), polyamines, several gamma-glutamyl dipeptides, and polypeptides were also elevated in obese children. |
|
Formal Description Interaction-ID: 85442 |
disease increases_quantity of drug/chemical compound |
| Comment | Additional AAs (alanine, glutamate, lysine, phenylalanine, and tyrosine), polyamines, several gamma-glutamyl dipeptides, and polypeptides were also elevated in obese children. |
|
Formal Description Interaction-ID: 85443 |
|
| Comment | Additional AAs (alanine, glutamate, lysine, phenylalanine, and tyrosine), polyamines, several gamma-glutamyl dipeptides, and polypeptides were also elevated in obese children. |
|
Formal Description Interaction-ID: 85444 |
disease increases_quantity of drug/chemical compound C-glycosyltryptophan |
| Comment | Kynurenine and kynurenate, which are involved with the dilation of blood vessels during inflammation, were elevated in obese children. |
|
Formal Description Interaction-ID: 85445 |
disease increases_quantity of drug/chemical compound |
| Comment | Kynurenine and kynurenate, which are involved with the dilation of blood vessels during inflammation, were elevated in obese children. |
|
Formal Description Interaction-ID: 85446 |
disease increases_quantity of drug/chemical compound |
| Comment | Additional AAs (alanine, glutamate, lysine, phenylalanine, and tyrosine), polyamines, several gamma-glutamyl dipeptides, and polypeptides were also elevated in obese children. |
|
Formal Description Interaction-ID: 85447 |
disease increases_quantity of drug/chemical compound |
| Comment | Additional AAs (alanine, glutamate, lysine, phenylalanine, and tyrosine), polyamines, several gamma-glutamyl dipeptides, and polypeptides were also elevated in obese children. |
|
Formal Description Interaction-ID: 85448 |
|
| Comment | Additional AAs (alanine, glutamate, lysine, phenylalanine, and tyrosine), polyamines, several gamma-glutamyl dipeptides, and polypeptides were also elevated in obese children. |
|
Formal Description Interaction-ID: 85449 |
|
| Comment | Additional AAs (alanine, glutamate, lysine, phenylalanine, and tyrosine), polyamines, several gamma-glutamyl dipeptides, and polypeptides were also elevated in obese children. |
|
Formal Description Interaction-ID: 85450 |
|
| Comment | Additional AAs (alanine, glutamate, lysine, phenylalanine, and tyrosine), polyamines, several gamma-glutamyl dipeptides, and polypeptides were also elevated in obese children. |
|
Formal Description Interaction-ID: 85451 |
|
| Comment | Consistent with elevated C-reactive protein concentrations, several metabolites indicative of inflammation and the activation of an immune response were elevated in the obese children. Bradykinin (a potent vasodilator), bradykinin-des-Arg(9) (an active metabolite of bradykinin), and HWESASLLR and HWESASXX (peptides that map to complement C3 protein) were elevated in obese children, consistent with the activation of an immune response. |
|
Formal Description Interaction-ID: 85452 |
|
| Comment | Consistent with elevated C-reactive protein concentrations, several metabolites indicative of inflammation and the activation of an immune response were elevated in the obese children. Bradykinin (a potent vasodilator), bradykinin-des-Arg(9) (an active metabolite of bradykinin), and HWESASLLR and HWESASXX (peptides that map to complement C3 protein) were elevated in obese children, consistent with the activation of an immune response. |
|
Formal Description Interaction-ID: 85453 |
disease increases_quantity of gene/protein His-Trp-Glu-Ser-Ala-Ser-Leu-Leu-Arg |
| Comment | Consistent with elevated C-reactive protein concentrations, several metabolites indicative of inflammation and the activation of an immune response were elevated in the obese children. Bradykinin (a potent vasodilator), bradykinin-des-Arg(9) (an active metabolite of bradykinin), and HWESASLLR and HWESASXX (peptides that map to complement C3 protein) were elevated in obese children, consistent with the activation of an immune response. |
|
Formal Description Interaction-ID: 85454 |
disease increases_quantity of gene/protein His-Trp-Glu-Ser-Ala-Ser-X-X |
| Comment | Levels of asparagine, aspartate, glycine, serine, and histidine were lower in obese children. |
|
Formal Description Interaction-ID: 85455 |
disease decreases_quantity of drug/chemical compound |
| Comment | Levels of asparagine, aspartate, glycine, serine, and histidine were lower in obese children. |
|
Formal Description Interaction-ID: 85456 |
|
| Comment | Levels of asparagine, aspartate, glycine, serine, and histidine were lower in obese children. |
|
Formal Description Interaction-ID: 85457 |
|
| Drugbank entries | Show/Hide entries for |
| Comment | Levels of asparagine, aspartate, glycine, serine, and histidine were lower in obese children. |
|
Formal Description Interaction-ID: 85458 |
|
| Comment | Levels of asparagine, aspartate, glycine, serine, and histidine were lower in obese children. |
|
Formal Description Interaction-ID: 85459 |
|
| Comment | There were significantly higher levels of alpha-hydroxybutyrate (AHB) and alpha-ketobutyrate (AKB) in obese children. |
|
Formal Description Interaction-ID: 85460 |
disease increases_quantity of drug/chemical compound |
| Comment | There were significantly higher levels of alpha-hydroxybutyrate (AHB) and alpha-ketobutyrate (AKB) in obese children. |
|
Formal Description Interaction-ID: 85461 |
disease increases_quantity of drug/chemical compound |
| Comment | Carnitine and the short-chain acylcarnitines [propionylcarnitine (3), butyrylcarnitine (4), and hexanoylcarnitine (6)] were elevated in obese children, whereas a few of the long-chain acylcarnitines [stearoylcarnitine (18) and oleoylcarnitine (18:1)] were lower. |
|
Formal Description Interaction-ID: 85465 |
|
| Comment | Carnitine and the short-chain acylcarnitines [propionylcarnitine (3), butyrylcarnitine (4), and hexanoylcarnitine (6)] were elevated in obese children, whereas a few of the long-chain acylcarnitines [stearoylcarnitine (18) and oleoylcarnitine (18:1)] were lower. |
|
Formal Description Interaction-ID: 85466 |
disease increases_quantity of drug/chemical compound Hexanoylcarnitine |
| Comment | Carnitine and the short-chain acylcarnitines [propionylcarnitine (3), butyrylcarnitine (4), and hexanoylcarnitine (6)] were elevated in obese children, whereas a few of the long-chain acylcarnitines [stearoylcarnitine (18) and oleoylcarnitine (18:1)] were lower. |
|
Formal Description Interaction-ID: 85467 |
disease decreases_quantity of drug/chemical compound Stearoylcarnitine |
| Comment | Carnitine and the short-chain acylcarnitines [propionylcarnitine (3), butyrylcarnitine (4), and hexanoylcarnitine (6)] were elevated in obese children, whereas a few of the long-chain acylcarnitines [stearoylcarnitine (18) and oleoylcarnitine (18:1)] were lower. |
|
Formal Description Interaction-ID: 85468 |
disease decreases_quantity of drug/chemical compound Acylcarnitine C18:1 |
| Comment | There was a striking decrease in lysolipids (glycerophosphocholines and glycerophosphoethanolamines) and dicarboxylated fatty acids (dodecanedioate, tetradecanedioate, and 2-hydroxydecanoate) in obese children. |
|
Formal Description Interaction-ID: 85469 |
disease decreases_quantity of drug/chemical compound |
| Comment | There was a striking decrease in lysolipids (glycerophosphocholines and glycerophosphoethanolamines) and dicarboxylated fatty acids (dodecanedioate, tetradecanedioate, and 2-hydroxydecanoate) in obese children. |
|
Formal Description Interaction-ID: 85470 |
disease decreases_quantity of drug/chemical compound Glycerophosphoethanolamine |
| Comment | There was a striking decrease in lysolipids (glycerophosphocholines and glycerophosphoethanolamines) and dicarboxylated fatty acids (dodecanedioate, tetradecanedioate, and 2-hydroxydecanoate) in obese children. |
|
Formal Description Interaction-ID: 85471 |
disease decreases_quantity of drug/chemical compound |
| Comment | There was a striking decrease in lysolipids (glycerophosphocholines and glycerophosphoethanolamines) and dicarboxylated fatty acids (dodecanedioate, tetradecanedioate, and 2-hydroxydecanoate) in obese children. |
|
Formal Description Interaction-ID: 85472 |
disease decreases_quantity of drug/chemical compound Tetradecanedioic acid |
| Comment | There was a striking decrease in lysolipids (glycerophosphocholines and glycerophosphoethanolamines) and dicarboxylated fatty acids (dodecanedioate, tetradecanedioate, and 2-hydroxydecanoate) in obese children. |
|
Formal Description Interaction-ID: 85473 |
disease decreases_quantity of drug/chemical compound 2-Hydroxydecanoate |
| Comment | The ketone body beta-hydroxybutyrate was significantly lower in obese children than in nonobese children. |
|
Formal Description Interaction-ID: 85474 |
disease decreases_quantity of drug/chemical compound |
| Comment | With the exceptions of cortisone, androsterone sulfate, and epiandrosterone sulfate, steroid derivatives were markedly higher in obese children. |
|
Formal Description Interaction-ID: 85475 |
disease increases_quantity of drug/chemical compound 4-Androsten-3beta,17beta-diol disulfate 1 |
| Comment | With the exceptions of cortisone, androsterone sulfate, and epiandrosterone sulfate, steroid derivatives were markedly higher in obese children. |
|
Formal Description Interaction-ID: 85476 |
disease increases_quantity of drug/chemical compound 4-Androsten-3beta,17beta-diol disulfate 2 |
| Comment | With the exceptions of cortisone, androsterone sulfate, and epiandrosterone sulfate, steroid derivatives were markedly higher in obese children. |
|
Formal Description Interaction-ID: 85477 |
disease increases_quantity of drug/chemical compound 5alpha-Androstan-3beta,17beta-diol disulfate |
| Comment | With the exceptions of cortisone, androsterone sulfate, and epiandrosterone sulfate, steroid derivatives were markedly higher in obese children. |
|
Formal Description Interaction-ID: 85478 |
disease increases_quantity of drug/chemical compound Androsteroid monosulfate 2 |
| Comment | With the exceptions of cortisone, androsterone sulfate, and epiandrosterone sulfate, steroid derivatives were markedly higher in obese children. |
|
Formal Description Interaction-ID: 85479 |
disease increases_quantity of drug/chemical compound |
| Comment | Consistent with elevated LDL-cholesterol concentrations in obese children, the cholesterol precursor lathosterol was significantly higher in obese children. |
|
Formal Description Interaction-ID: 85480 |
disease increases_quantity of drug/chemical compound |
| Comment | Mannose and pyruvate were higher, but glycerate was lower, in obese children than in nonobese children. |
|
Formal Description Interaction-ID: 85481 |
|
| Comment | Mannose and pyruvate were higher, but glycerate was lower, in obese children than in nonobese children. |
|
Formal Description Interaction-ID: 85482 |
|
| Comment | Mannose and pyruvate were higher, but glycerate was lower, in obese children than in nonobese children. |
|
Formal Description Interaction-ID: 85483 |
|
| Comment | In the tricarboxylic acid (TCA) cycle, the only metabolite that reached significance was citrate, which was lower in obese children. |
|
Formal Description Interaction-ID: 85484 |
|
| Comment | Consistent with elevated uric acid, higher levels of purine and pyrimidine metabolites were seen in obese children. Levels of the purine catabolite xanthine were significantly elevated, which may have reflected an increased generation of H2O2 during the conversion of hypoxanthine to xanthine by xanthine oxidase as part of an inflammatory response. Xanthine oxidase also converts xanthine to urate, the levels of which were also higher in the obese-children group. |
|
Formal Description Interaction-ID: 85485 |
|
| Drugbank entries | Show/Hide entries for |
| Comment | Consistent with elevated uric acid, higher levels of purine and pyrimidine metabolites were seen in obese children. Levels of the purine catabolite xanthine were significantly elevated, which may have reflected an increased generation of H2O2 during the conversion of hypoxanthine to xanthine by xanthine oxidase as part of an inflammatory response. Xanthine oxidase also converts xanthine to urate, the levels of which were also higher in the obese-children group. |
|
Formal Description Interaction-ID: 85486 |
|