General Information:

Id: 8,314
Diseases: Gastrointestinal
Inflammation
Rattus norvegicus
male
western albino rats (3‚Äď4 weeks of age)
brain
article/cited
Reference: El-Ansary A et al.(2017) Glutamate excitotoxicity induced by orally administered propionic acid, a short chain fatty acid can be ameliorated by bee pollen Lipids Health Dis 16: 96 [PMID: 28532421]

Interaction Information:

Comment Propionic acid is a metabolite in the gut. It is mainly produced by clostridia species. (cited information)
Formal Description
Interaction-ID: 84299

environment

Clostridia

increases_quantity of

drug/chemical compound

Propanoate

in intestine
Comment PPA-treated rats show a significant increase in Glu and the Glu/Gln ratio with a concomitant decrease of GABA, Gln, and the GABA/Glu ratio, compared to untreated rats.
Formal Description
Interaction-ID: 84306

drug/chemical compound

Propanoate

increases_quantity of

drug/chemical compound

Glutamate

in brain
Comment PPA-treated rats show a significant increase in Glu and the Glu/Gln ratio with a concomitant decrease of GABA, Gln, and the GABA/Glu ratio, compared to untreated rats.
Formal Description
Interaction-ID: 84308

drug/chemical compound

Propanoate

increases_activity of

phenotype

increased glutamate/glutamine ratio

in brain
Comment PPA-treated rats show a significant increase in Glu and the Glu/Gln ratio with a concomitant decrease of GABA, Gln, and the GABA/Glu ratio, compared to untreated rats.
Formal Description
Interaction-ID: 84309

drug/chemical compound

Propanoate

decreases_quantity of

drug/chemical compound

GABA

in brain
Comment PPA-treated rats show a significant increase in Glu and the Glu/Gln ratio with a concomitant decrease of GABA, Gln, and the GABA/Glu ratio, compared to untreated rats.
Formal Description
Interaction-ID: 84310

drug/chemical compound

Propanoate

decreases_quantity of

drug/chemical compound

Glutamine

in brain
Comment PPA-treated rats show a significant increase in Glu and the Glu/Gln ratio with a concomitant decrease of GABA, Gln, and the GABA/Glu ratio, compared to untreated rats.
Formal Description
Interaction-ID: 84311

drug/chemical compound

Propanoate

decreases_activity of

phenotype

decreased GABA/glutamine ratio

in brain
Comment Propionic acid (PPA) is neurotoxic. (cited information)
Formal Description
Interaction-ID: 84312

drug/chemical compound

Propanoate

increases_activity of

process

neuron death

in brain