General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J Endocrinol 204: 93-104 [PMID: 19770177]

Interaction Information:

Comment Activation of AKT by insulin elicits phosphorylation of both TORC2 and PGC-1alpha leading to their degradation.
Formal Description
Interaction-ID: 4864

gene/protein

AKT1

decreases_quantity of

gene/protein

PPARGC1A

in liver; via increased degradation of PPARGC1A
Drugbank entries Show/Hide entries for AKT1