CIDeRplusGeneral Information:
| Id: | 8,176 |
| Diseases: |
Cancer
Metabolic |
| Homo sapiens | |
| Lung adenocarcinoma A549 cells | |
| article | |
| Reference: | Fan TW et al.(2006) Integrating metabolomics and transcriptomics for probing SE anticancer mechanisms Drug Metab. Rev. 38: 707-732 [PMID: 17145697] |
Interaction Information:
| Comment | Incubation of lung adenocarcinoma cells with selenite or selenomethionine results in growth inhibition, accompanied by alterations in cell morphology and cytoskeleton structures, as well as inhibition of mitochondrial redox activity. |
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Formal Description Interaction-ID: 82233 |
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| Comment | Selenite exposure enhances apoptosis in lung adenocarcinoma cells, as evidenced by an increase in DNA fragmentation and caspase activity. |
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Formal Description Interaction-ID: 82234 |
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| Comment | Incubation of lung adenocarcinoma cells with selenite or selenomethionine results in growth inhibition, accompanied by alterations in cell morphology and cytoskeleton structures, as well as inhibition of mitochondrial redox activity. |
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Formal Description Interaction-ID: 82235 |
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| Comment | The concentration of essential amino acids Ile, Leu, Val, Arg, Tyr and nonessential amino acid Gln as well as spermine, and phosphorylcholine increases after 24-h treatment with selenite. |
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Formal Description Interaction-ID: 82237 |
drug/chemical compound increases_quantity of drug/chemical compound |
| Comment | The concentration of essential amino acids Ile, Leu, Val, Arg, Tyr and nonessential amino acid Gln as well as spermine, and phosphorylcholine increases after 24-h treatment with selenite. |
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Formal Description Interaction-ID: 82238 |
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| Comment | The concentration of essential amino acids Ile, Leu, Val, Arg, Tyr and nonessential amino acid Gln as well as spermine, and phosphorylcholine increases after 24-h treatment with selenite. |
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Formal Description Interaction-ID: 82239 |
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| Comment | The concentration of essential amino acids Ile, Leu, Val, Arg, Tyr and nonessential amino acid Gln as well as spermine, and phosphorylcholine increases after 24-h treatment with selenite. |
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Formal Description Interaction-ID: 82240 |
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| Comment | The concentration of essential amino acids Ile, Leu, Val, Arg, Tyr and nonessential amino acid Gln as well as spermine, and phosphorylcholine increases after 24-h treatment with selenite. |
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Formal Description Interaction-ID: 82241 |
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| Comment | The concentration of essential amino acids Ile, Leu, Val, Arg, Tyr and nonessential amino acid Gln as well as spermine, and phosphorylcholine increases after 24-h treatment with selenite. |
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Formal Description Interaction-ID: 82242 |
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| Comment | The concentration of essential amino acids Ile, Leu, Val, Arg, Tyr and nonessential amino acid Gln as well as spermine, and phosphorylcholine increases after 24-h treatment with selenite. |
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Formal Description Interaction-ID: 82243 |
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| Drugbank entries | Show/Hide entries for |
| Comment | The concentration of essential amino acids Ile, Leu, Val, Arg, Tyr and nonessential amino acid Gln as well as spermine, and phosphorylcholine increases after 24-h treatment with selenite. |
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Formal Description Interaction-ID: 82244 |
drug/chemical compound increases_quantity of drug/chemical compound |
| Comment | The concentration of Glu, Asp, glutathione (GSH), lactate, and taurine decreases after 24-h treatment with selenite. |
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Formal Description Interaction-ID: 82245 |
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| Comment | The concentration of Glu, Asp, glutathione (GSH), and taurine decreases after 24-h treatment with selenite. |
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Formal Description Interaction-ID: 82246 |
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| Comment | The concentration of Glu, Asp, glutathione (GSH), and taurine decreases after 24-h treatment with selenite. The large depletion of GSH in selenite-treated cells results from oxidative stress. |
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Formal Description Interaction-ID: 82247 |
drug/chemical compound decreases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | The concentration of Glu, Asp, glutathione (GSH), and taurine decreases after 24-h treatment with selenite. |
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Formal Description Interaction-ID: 82248 |
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| Comment | Addition of selenomethionine (SeM) induces depletion of phosphorylcholine, in contrast to its accumulation in response to selenite. These differences in metabolic responses between selenite- and SeM-treated cells suggest distinct mechanisms of toxicity for the two selenium forms. |
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Formal Description Interaction-ID: 82256 |
drug/chemical compound decreases_quantity of drug/chemical compound |
| Comment | Addition of selenite induces a time-dependent increase in H2O2 production. This is consistent with the GSH depletion in selenite-treated cells. |
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Formal Description Interaction-ID: 82257 |
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| Comment | Addition of selenite induces a time-dependent increase in H2O2 production. This is consistent with the GSH depletion in selenite-treated cells. |
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Formal Description Interaction-ID: 82258 |
drug/chemical compound increases_activity of process |
| Comment | The concentration of Glu, Asp, glutathione (GSH), lactate, and taurine decreases after 24-h treatment with selenite. |
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Formal Description Interaction-ID: 82259 |
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| Comment | Selenite treatment results in down-regulation of 5 glycolytic enzymes, glucose-6-phosphate isomerase (GPI), phosphofructokinase 2 (PFK2, PFKFB), aldolase A (ALDOA), triosephosphate isomerase (TPI1) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). This explains the reduced synthesis of lactate or glycolytic flux in response to selenite. |
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Formal Description Interaction-ID: 82276 |
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| Drugbank entries | Show/Hide entries for GPI |
| Comment | Selenite treatment results in down-regulation of 5 glycolytic enzymes, glucose-6-phosphate isomerase (GPI), phosphofructokinase 2 (PFK2, PFKFB) , aldolase A (ALDOA), triosephosphate isomerase (TPI1) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). This explains the reduced synthesis of lactate or glycolytic flux in response to selenite. |
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Formal Description Interaction-ID: 82277 |
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| Comment | Selenite treatment results in down-regulation of 5 glycolytic enzymes, glucose-6-phosphate isomerase (GPI), phosphofructokinase 2 (PFK2, PFKFB) , aldolase A (ALDOA), triosephosphate isomerase (TPI1) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). This explains the reduced synthesis of lactate or glycolytic flux in response to selenite. |
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Formal Description Interaction-ID: 82278 |
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| Drugbank entries | Show/Hide entries for ALDOA |
| Comment | Selenite treatment results in down-regulation of 5 glycolytic enzymes, glucose-6-phosphate isomerase (GPI), phosphofructokinase 2 (PFK2, PFKFB) , aldolase A (ALDOA), triosephosphate isomerase (TPI1) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). This explains the reduced synthesis of lactate or glycolytic flux in response to selenite. |
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Formal Description Interaction-ID: 82279 |
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| Drugbank entries | Show/Hide entries for TPI1 |
| Comment | Selenite treatment results in down-regulation of 5 glycolytic enzymes, glucose-6-phosphate isomerase (GPI), phosphofructokinase 2 (PFK2, PFKFB) , aldolase A (ALDOA), triosephosphate isomerase (TPI1) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). This explains the reduced synthesis of lactate or glycolytic flux in response to selenite. |
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Formal Description Interaction-ID: 82280 |
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| Drugbank entries | Show/Hide entries for GAPDH |
| Comment | Selenite treatment results in down-regulation of mitochondrial pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, isocitrate dehydrogenase, and malate dehydrogenase. This may account for the attenuated TCA cycle activity, which, together with the reduced glycolytic activity, leads to the reduced synthesis of glutamate from glucose. |
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Formal Description Interaction-ID: 82281 |
drug/chemical compound decreases_activity of complex/PPI Pyruvate dehydrogenase complex |
| Comment | Selenite treatment results in lower expression of acetyl-CoA carboxylase, which catalyzes the rate-limiting step in the biogenesis of long-chain fatty acids. |
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Formal Description Interaction-ID: 82296 |
drug/chemical compound decreases_quantity of gene/protein ACAC |