General Information:

Id: 8,154
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
article
Reference: Axelsson AS et al.(2017) Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes Nat Commun 8: 15652 [PMID: 28585545]

Interaction Information:

Comment Immunostainings showed a reduction of MAFA expression in Sox5-kd cells, while MAFB, NKX6.1 and PAX6 were unaffected. MAFA but not PDX1 protein levels were reduced in Sox5-kd cells.
Formal Description
Interaction-ID: 81795

gene/protein

SOX5

affects_expression of

gene/protein

MAFA

Comment Sox5 knockdown impairs glucose-stimulated insulin secretion.
Formal Description
Interaction-ID: 81908
Comment Sox5 knockdown impairs glucose metabolism.
Formal Description
Interaction-ID: 81909

gene/protein

SOX5

affects_activity of

process

glucose metabolic process

Comment Alanine and lactate, which are both generated from pyruvate, were elevated in Sox5-kd cells relative to control cells at high glucose.
Formal Description
Interaction-ID: 81910

gene/protein

SOX5

affects_quantity of

drug/chemical compound

Alanine

Comment Alanine and lactate, which are both generated from pyruvate, were elevated in Sox5-kd cells relative to control cells at high glucose.
Formal Description
Interaction-ID: 81912

gene/protein

SOX5

affects_quantity of

drug/chemical compound

Lactate

Comment Sox5 expression was reduced after silencing the transcription factor Yin Yang 1 (Yy1), which was in turn significantly affected by palmitate treatment. The inhibitory effect of palmitate on Sox5 expression was abolished after Yy1 knockdown.
Formal Description
Interaction-ID: 81916

gene/protein

YY1

decreases_expression of

gene/protein

SOX5

Comment Sox5 expression was reduced after silencing the transcription factor Yin Yang 1 (Yy1), which was in turn significantly affected by palmitate treatment. The inhibitory effect of palmitate on Sox5 expression was abolished after Yy1 knockdown.
Formal Description
Interaction-ID: 81917

drug/chemical compound

Palmitic acid

decreases_expression of

gene/protein

SOX5

Drugbank entries Show/Hide entries for Palmitic acid
Comment Valproic acid elevates Sox5 expression and insulin secretion.
Formal Description
Interaction-ID: 81919

drug/chemical compound

Valproic acid

increases_expression of

gene/protein

SOX5

Drugbank entries Show/Hide entries for Valproic acid
Comment Valproic acid elevates Sox5 expression and insulin secretion.
Formal Description
Interaction-ID: 81920

drug/chemical compound

Valproic acid

increases_activity of

process

insulin secretion involved in cellular response to glucose stimulus

Drugbank entries Show/Hide entries for Valproic acid