CIDeRplusGeneral Information:
| Id: | 8,153 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Gooding JR et al.(2016) Metabolomics applied to the pancreatic islet Arch. Biochem. Biophys. 589: 120-130 [PMID: 26116790] |
Interaction Information:
| Comment | Chronic exposure to hyperglycemia caused glutamine concentrations and C4-glutamate labeling from U-13C-glucose to decrease, while GABA concentrations increased. These changes may indicate changes in flux through the GABA shunt pathway and glutamate dehydrogenase which have both been implicated in beta-cell function. While this study did not investigate the mechanism of these changes, the results partly align with another report that employed the GABA transaminase inhibitor gabaculine and succinic semialdehyde supplementation of the GABA shunt to link GABA metabolism to GSIS in rat islets. |
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Formal Description Interaction-ID: 82097 |
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