CIDeRplusGeneral Information:
| Id: | 8,153 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Gooding JR et al.(2016) Metabolomics applied to the pancreatic islet Arch. Biochem. Biophys. 589: 120-130 [PMID: 26116790] |
Interaction Information:
| Comment | The second phase of insulin secretion correlates with elevated pools of glycolytic and TCA intermediates. Furthermore, the changes in nucleotide levels, PPP intermediates and long chain fatty acids observed in the first phase by unbiased LC‚ÄďMS/MS are sustained in the second phase. Also, PPP intermediates ribose 5-phophate and 6-phosphogluconate, and the amino acids alanine, (iso)leucine, lysine, serine, and medium and long chain fatty acids associate with the second phase, whereas aspartate, sarcosine, and 3-aminobutyric acid are down-regulated by glucose (unbiased GC‚ÄďMS. In another study, targeted LC‚ÄďMS/MS analyses on 832/13 cells demonstrated increases in ATP, GTP, NADH, NADPH, glutamine, glutamate, succinyl-CoA and malonyl-CoA pools after 45 min of glucose stimulation whereas adenosine, AMP, aspartate and HMG-CoA levels decreased. |
|
Formal Description Interaction-ID: 82056 |
process insulin secretion, second phase decreases_quantity of drug/chemical compound |