CIDeRplusGeneral Information:
| Id: | 8,153 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Gooding JR et al.(2016) Metabolomics applied to the pancreatic islet Arch. Biochem. Biophys. 589: 120-130 [PMID: 26116790] |
Interaction Information:
| Comment | Using untargeted GC‚ÄďMS in 832/13 cells, first phase insulin secretion was also found to be negatively associated with aspartate, lysine and proline and positively with ribose-5-phosphate, 6-phosphoglucono-1,5-lactone, gulonic acid gamma-lactone, ribitol, sedoheptulose, N-acetylglucosamine, lactose, sorbitol, fructose, alanine, and 3-aminoisobutyrate. In another GC‚ÄďMS based study, first phase insulin secretion was found to be negatively correlated with aspartate, (iso)leucine, hydroxyproline, proline and valine, and positively correlated with ribose-5-phosphate, lactate, glycerol-3-phosphate, alanine, cysteine, glutamate, and glycine. Another study found an inverse relationship between asparagine, glutamine, lysine, serine, long chain fatty acids, long-chain acyl-CoAs, HMG-CoA, NADP, mono- and diphosphonucleotides and first phase insulin secretion using unbiased LC‚ÄďMS/MS in glucose-stimulated 832/13 cells. In contrast, this group also observed increases in farnesyl pyrophosphate, NADH, 6-phosphogluconate, sedoheptulose phosphate, phosphoribosyl pyrophosphate, ZMP, glycinamideribotide, and GDP-mannose. |
|
Formal Description Interaction-ID: 81986 |
process insulin secretion, first phase decreases_quantity of drug/chemical compound |