CIDeRplusGeneral Information:
| Id: | 8,105 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Rattus norvegicus | |
| BTO:0003318 INS-1 823/13 cell | |
| article | |
| Reference: | Huang M and Joseph JW(2012) Metabolomic analysis of pancreatic beta-cell insulin release in response to glucose Islets 4: 210-222 [PMID: 22847496] |
Interaction Information:
| Comment | Defining the key metabolic pathways that are important for fuel-regulated insulin secretion is critical to providing a complete picture of how nutrients regulate insulin secretion. 41 metabolites were consistently identified as biomarker for GSIS by orthogonal partial least-squares (OPLS). Most of the identified metabolites are from common metabolic pathways including glycolytic, sorbitol-aldose reductase pathway, pentose phosphate pathway, and the TCA cycle suggesting these pathways play an important role in GSIS. Lipids and related products were also shown to contribute to the clustering of high glucose sample groups. Amino acids lysine, tyrosine, alanine and serine were upregulated by glucose whereas aspartic acid was downregulated by glucose suggesting these amino acids might play a key role in GSIS. |
|
Formal Description Interaction-ID: 80755 |
decreases_quantity of drug/chemical compound |