General Information:

Id: 792 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Koren J 3rd et al.(2009) Chaperone signalling complexes in Alzheimers disease J. Cell. Mol. Med. 13: 619-630 [PMID: 19449461]

Interaction Information:

Comment Akt, an oncogenic master kinase that can phosphorylate tau, is also elevated in AD.
Formal Description
Interaction-ID: 4693

disease

Alzheimer disease

increases_quantity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment Akt can regulate CHIP expression levels.
Formal Description
Interaction-ID: 4695

gene/protein

AKT1

affects_expression of

gene/protein

STUB1

Drugbank entries Show/Hide entries for AKT1
Comment Akt enhances the activity of PAR1, to promote phosphorylation of tau at S262/S356, a phospho-tau species that is not recognised by the Hsp90/CHIP complex.
Formal Description
Interaction-ID: 4696

gene/protein

AKT1

increases_activity of

gene/protein

MARK2

Drugbank entries Show/Hide entries for AKT1
Comment Akt, an oncogenic master kinase that can phosphorylate tau, is also elevated in AD.
Formal Description
Interaction-ID: 4697

gene/protein

AKT1

affects_phosphorylation of

gene/protein

MAPT

Drugbank entries Show/Hide entries for AKT1