CIDeRplusGeneral Information:
| Id: | 772 |
| Diseases: |
Amyotrophic lateral sclerosis
|
| Mus musculus | |
| male | |
| BTO:0001103 skeletal muscle | |
| article | |
| Reference: | Muller FL et al.(2007) Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 [PMID: 17584954] |
Interaction Information:
| Comment | ROS production is increased in muscle mitochondria during aging and is correlated with muscle atrophy. State 1 ROS production was increased nearly twofold in mitochondria isolated from hindlimb skeletal muscle from 28-mo-old male mice compared with mitochondria from 10-mo-old mice. |
|
Formal Description Interaction-ID: 4356 |
process increases_quantity of drug/chemical compound Reactive oxygen species |
| Comment | ROS production is increased in muscle mitochondria during aging and is correlated with muscle atrophy. Gastrocnemius muscle mass was reduced nearly 13% at 28 mo in male wild-type mice and nearly 40% at 32 mo compared with 10-mo-old adult control mice. |
|
Formal Description Interaction-ID: 4357 |
|