General Information:

Id: 757 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1 wt or SOD1G93A transgenic mouse, transfected with human wt SOD1 or human SOD1G93A
BTO:0001103 skeletal muscle
article
Reference: Pierce A et al.(2008) GAPDH is conformationally and functionally altered in association with oxidative stress in mouse models of amyotrophic lateral sclerosis J. Mol. Biol. 382: 1195-1210 [PMID: 18706911]

Interaction Information:

Comment Iron/ascorbate-induced oxidative stress induced a decrease in BisANS incorporation in creatine kinase (CK) and GAPDH in vitro and a decrease in activity of both enzymes.
Formal Description
Interaction-ID: 4291

process

response to oxidative stress

decreases_activity of

gene/protein

CKM

Drugbank entries Show/Hide entries for CKM