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Field	Query

	Field	Term

General Information:

Id:	7,567 (click here to show other Interactions for entry)
Diseases:	Metabolic
Organism:	Homo sapiens
Publication type:	article
Reference:	Muenchhoff J et al.(2017) Plasma apolipoproteins and physical and cognitive health in very old individuals Neurobiol Aging 55: 49-60 [PMID: 28419892]

Interaction Information:

Comment	Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower
Formal Description Interaction-ID: 74975	gene/protein mutant APOE (isoform E4) decreases_quantity of gene/protein APOA1 in plasma

Comment	Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower
Formal Description Interaction-ID: 74981	gene/protein mutant APOE (isoform E4) decreases_quantity of gene/protein APOA2 in plasma

Comment	Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower.
Formal Description Interaction-ID: 74982	gene/protein mutant APOE (isoform E4) decreases_quantity of gene/protein APOB in plasma

Comment	Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower
Formal Description Interaction-ID: 74983	gene/protein mutant APOE (isoform E4) decreases_quantity of gene/protein APOC3 in plasma

Comment	Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower
Formal Description Interaction-ID: 74984	gene/protein mutant APOE (isoform E4) decreases_quantity of gene/protein APOH in plasma
Drugbank entries	Show/Hide entries for APOH
Drugbank DB02944	Alpha-D-Mannose not specified APOH
Drugbank DB02944	Alpha-D-Mannose not specified APOH

Comment	Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower
Formal Description Interaction-ID: 74985	gene/protein mutant APOE (isoform E4) decreases_quantity of gene/protein APOE in plasma
Drugbank entries	Show/Hide entries for APOE
Drugbank DB00062	Human Serum Albumin not specified APOE
Drugbank DB00064	Serum albumin iodonated not specified APOE
Drugbank DB00062	Human Serum Albumin not specified APOE
Drugbank DB00064	Serum albumin iodonated not specified APOE

Comment	Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower
Formal Description Interaction-ID: 74986	gene/protein mutant APOE (isoform E4) decreases_quantity of gene/protein CLU in plasma

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