General Information:

Id: 7,567
Diseases: Metabolic
Homo sapiens
article
Reference: Muenchhoff J et al.(2017) Plasma apolipoproteins and physical and cognitive health in very old individuals Neurobiol Aging 55: 49-60 [PMID: 28419892]

Interaction Information:

Comment Linear regression analyses showed that there were lower levels of plasma apolipoproteins in increasingly older age bands by 1.21, 28.54, 35.24, 0.30, and 6.75 mg/mL per decade for ApoA1, ApoA2, ApoB, ApoC3, and ApoH, respectively.
Formal Description
Interaction-ID: 74912

process

aging

decreases_quantity of

gene/protein

APOA1

in plasma
Comment Linear regression analyses showed that there were lower levels of plasma apolipoproteins in increasingly older age bands by 1.21, 28.54, 35.24, 0.30, and 6.75 mg/mL per decade for ApoA1, ApoA2, ApoB, ApoC3, and ApoH, respectively.
Formal Description
Interaction-ID: 74966

process

aging

decreases_quantity of

gene/protein

APOA2

in plasma
Comment Linear regression analyses showed that there were lower levels of plasma apolipoproteins in increasingly older age bands by 1.21, 28.54, 35.24, 0.30, and 6.75 mg/mL per decade for ApoA1, ApoA2, ApoB, ApoC3, and ApoH, respectively.
Formal Description
Interaction-ID: 74967

process

aging

decreases_quantity of

gene/protein

APOB

in plasma
Comment Linear regression analyses showed that there were lower levels of plasma apolipoproteins in increasingly older age bands by 1.21, 28.54, 35.24, 0.30, and 6.75 mg/mL per decade for ApoA1, ApoA2, ApoB, ApoC3, and ApoH, respectively.
Formal Description
Interaction-ID: 74968

process

aging

decreases_quantity of

gene/protein

APOC3

in plasma
Comment Linear regression analyses showed that there were lower levels of plasma apolipoproteins in increasingly older age bands by 1.21, 28.54, 35.24, 0.30, and 6.75 mg/mL per decade for ApoA1, ApoA2, ApoB, ApoC3, and ApoH, respectively.
Formal Description
Interaction-ID: 74969

process

aging

decreases_quantity of

gene/protein

APOH

in plasma
Drugbank entries Show/Hide entries for APOH
Comment Linear regression analyses showed that the levels in plasma of ApoE and ApoJ had U-shaped trends in increasingly older age.
Formal Description
Interaction-ID: 74970

process

aging

affects_quantity of

gene/protein

APOE

in plasma
Drugbank entries Show/Hide entries for APOE
Comment Linear regression analyses showed that the levels in plasma of ApoE and ApoJ had U-shaped trends in increasingly older age.
Formal Description
Interaction-ID: 74973

process

aging

affects_quantity of

gene/protein

CLU

in plasma
Comment Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower
Formal Description
Interaction-ID: 74975

gene/protein mutant

APOE (isoform E4)

decreases_quantity of

gene/protein

APOA1

in plasma
Comment Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower
Formal Description
Interaction-ID: 74981

gene/protein mutant

APOE (isoform E4)

decreases_quantity of

gene/protein

APOA2

in plasma
Comment Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower.
Formal Description
Interaction-ID: 74982

gene/protein mutant

APOE (isoform E4)

decreases_quantity of

gene/protein

APOB

in plasma
Comment Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower
Formal Description
Interaction-ID: 74983

gene/protein mutant

APOE (isoform E4)

decreases_quantity of

gene/protein

APOC3

in plasma
Comment Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower
Formal Description
Interaction-ID: 74984

gene/protein mutant

APOE (isoform E4)

decreases_quantity of

gene/protein

APOH

in plasma
Drugbank entries Show/Hide entries for APOH
Comment Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower
Formal Description
Interaction-ID: 74985

gene/protein mutant

APOE (isoform E4)

decreases_quantity of

gene/protein

APOE

in plasma
Drugbank entries Show/Hide entries for APOE
Comment Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower
Formal Description
Interaction-ID: 74986

gene/protein mutant

APOE (isoform E4)

decreases_quantity of

gene/protein

CLU

in plasma
Comment Plasma levels of all apolipoproteins (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) except ApoH were higher in females than in males, although for ApoA2 this did not reach statistical significance. Levels of ApoH were not significantly different between males and females.
Formal Description
Interaction-ID: 74988

phenotype

sex, female

increases_quantity of

gene/protein

APOA1

in plasma; in increasingly older age groups of patients
Comment Plasma levels of all apolipoproteins (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) except ApoH were higher in females than in males, although for ApoA2 this did not reach statistical significance. Levels of ApoH were not significantly different between males and females.
Formal Description
Interaction-ID: 74989

phenotype

sex, female

increases_quantity of

gene/protein

APOB

in plasma; in increasingly older age groups of patients
Comment Plasma levels of all apolipoproteins (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) except ApoH were higher in females than in males, although for ApoA2 this did not reach statistical significance. Levels of ApoH were not significantly different between males and females.
Formal Description
Interaction-ID: 74991

phenotype

sex, female

increases_quantity of

gene/protein

APOC3

in plasma; in increasingly older age groups of patients
Comment Plasma levels of all apolipoproteins (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) except ApoH were higher in females than in males, although for ApoA2 this did not reach statistical significance. Levels of ApoH were not significantly different between males and females.
Formal Description
Interaction-ID: 74992

phenotype

sex, female

affects_quantity of

gene/protein

APOE

in plasma; in increasingly older age groups of patients
Drugbank entries Show/Hide entries for APOE
Comment Plasma levels of all apolipoproteins (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) except ApoH were higher in females than in males, although for ApoA2 this did not reach statistical significance. Levels of ApoH were not significantly different between males and females.
Formal Description
Interaction-ID: 74993

phenotype

sex, female

increases_quantity of

gene/protein

CLU

in plasma; in increasingly older age groups of patients
Comment Plasma levels of all apolipoproteins (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) except ApoH were higher in females than in males, although for ApoA2 this did not reach statistical significance. Levels of ApoH were not significantly different between males and females.
Formal Description
Interaction-ID: 74995

phenotype

sex, female

increases_quantity of

gene/protein

APOH

in plasma; in increasingly older age groups of patients
Drugbank entries Show/Hide entries for APOH
Comment Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant.
Formal Description
Interaction-ID: 74996

phenotype

sex, female

affects_activity of

process

cognition

in 56-86 year old females with decreased levels of ApoB, ApoE, ApoH. ApoJ, ApoA1, ApoA2, ApoC3 in plasma
Comment Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant.
Formal Description
Interaction-ID: 75002

phenotype

sex, male

NOT affects_activity of

process

cognition

in 56-86 year old males with decreased levels of ApoB, ApoE, ApoH, ApoJ, ApoA1, ApoA2, ApoC3 in plasma
Comment Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant.
Formal Description
Interaction-ID: 75003

phenotype

decreased level of APOB

increases_activity of

process

cognition

in 56-86 year old females
Comment Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant.
Formal Description
Interaction-ID: 75004

phenotype

decreased level of APOE

increases_activity of

process

cognition

in 56-86 year old females
Comment Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant.
Formal Description
Interaction-ID: 75006

phenotype

decreased level of APOH

increases_activity of

process

cognition

in 56-86 year old females
Comment Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant.
Formal Description
Interaction-ID: 75007

phenotype

decreased level of CLU

increases_activity of

process

cognition

in 56-86 year old females
Comment Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant.
Formal Description
Interaction-ID: 75008

phenotype

decreased level of APOA1

increases_activity of

process

cognition

in 56-86 year old females
Comment Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant.
Formal Description
Interaction-ID: 75010

phenotype

decreased level of APOA2

increases_activity of

process

cognition

in 56-86 year old females
Comment Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant.
Formal Description
Interaction-ID: 75011

phenotype

decreased level of APOC3

increases_activity of

process

cognition

in 56-86 year old females