General Information:
Id: | 7,567 |
Diseases: |
Metabolic
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Homo sapiens | |
article | |
Reference: | Muenchhoff J et al.(2017) Plasma apolipoproteins and physical and cognitive health in very old individuals Neurobiol Aging 55: 49-60 [PMID: 28419892] |
Interaction Information:
Comment | Linear regression analyses showed that there were lower levels of plasma apolipoproteins in increasingly older age bands by 1.21, 28.54, 35.24, 0.30, and 6.75 mg/mL per decade for ApoA1, ApoA2, ApoB, ApoC3, and ApoH, respectively. |
Formal Description Interaction-ID: 74912 |
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Comment | Linear regression analyses showed that there were lower levels of plasma apolipoproteins in increasingly older age bands by 1.21, 28.54, 35.24, 0.30, and 6.75 mg/mL per decade for ApoA1, ApoA2, ApoB, ApoC3, and ApoH, respectively. |
Formal Description Interaction-ID: 74966 |
|
Comment | Linear regression analyses showed that there were lower levels of plasma apolipoproteins in increasingly older age bands by 1.21, 28.54, 35.24, 0.30, and 6.75 mg/mL per decade for ApoA1, ApoA2, ApoB, ApoC3, and ApoH, respectively. |
Formal Description Interaction-ID: 74967 |
|
Comment | Linear regression analyses showed that there were lower levels of plasma apolipoproteins in increasingly older age bands by 1.21, 28.54, 35.24, 0.30, and 6.75 mg/mL per decade for ApoA1, ApoA2, ApoB, ApoC3, and ApoH, respectively. |
Formal Description Interaction-ID: 74968 |
|
Comment | Linear regression analyses showed that there were lower levels of plasma apolipoproteins in increasingly older age bands by 1.21, 28.54, 35.24, 0.30, and 6.75 mg/mL per decade for ApoA1, ApoA2, ApoB, ApoC3, and ApoH, respectively. |
Formal Description Interaction-ID: 74969 |
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Drugbank entries | Show/Hide entries for APOH |
Comment | Linear regression analyses showed that the levels in plasma of ApoE and ApoJ had U-shaped trends in increasingly older age. |
Formal Description Interaction-ID: 74970 |
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Drugbank entries | Show/Hide entries for APOE |
Comment | Linear regression analyses showed that the levels in plasma of ApoE and ApoJ had U-shaped trends in increasingly older age. |
Formal Description Interaction-ID: 74973 |
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Comment | Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower |
Formal Description Interaction-ID: 74975 |
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Comment | Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower |
Formal Description Interaction-ID: 74981 |
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Comment | Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower. |
Formal Description Interaction-ID: 74982 |
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Comment | Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower |
Formal Description Interaction-ID: 74983 |
|
Comment | Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower |
Formal Description Interaction-ID: 74984 |
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Drugbank entries | Show/Hide entries for APOH |
Comment | Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower |
Formal Description Interaction-ID: 74985 |
|
Drugbank entries | Show/Hide entries for APOE |
Comment | Apolipoprotein (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) levels trended lower in APOE epsilon 4 homozygotes and heterozygotes compared with noncarriers, with ApoE and ApoJ being significantly lower |
Formal Description Interaction-ID: 74986 |
|
Comment | Plasma levels of all apolipoproteins (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) except ApoH were higher in females than in males, although for ApoA2 this did not reach statistical significance. Levels of ApoH were not significantly different between males and females. |
Formal Description Interaction-ID: 74988 |
phenotype sex, female increases_quantity of gene/protein |
Comment | Plasma levels of all apolipoproteins (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) except ApoH were higher in females than in males, although for ApoA2 this did not reach statistical significance. Levels of ApoH were not significantly different between males and females. |
Formal Description Interaction-ID: 74989 |
phenotype sex, female increases_quantity of gene/protein |
Comment | Plasma levels of all apolipoproteins (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) except ApoH were higher in females than in males, although for ApoA2 this did not reach statistical significance. Levels of ApoH were not significantly different between males and females. |
Formal Description Interaction-ID: 74991 |
phenotype sex, female increases_quantity of gene/protein |
Comment | Plasma levels of all apolipoproteins (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) except ApoH were higher in females than in males, although for ApoA2 this did not reach statistical significance. Levels of ApoH were not significantly different between males and females. |
Formal Description Interaction-ID: 74992 |
phenotype sex, female affects_quantity of gene/protein |
Drugbank entries | Show/Hide entries for APOE |
Comment | Plasma levels of all apolipoproteins (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) except ApoH were higher in females than in males, although for ApoA2 this did not reach statistical significance. Levels of ApoH were not significantly different between males and females. |
Formal Description Interaction-ID: 74993 |
phenotype sex, female increases_quantity of gene/protein |
Comment | Plasma levels of all apolipoproteins (ApoA1, ApoA2, ApoB, ApoC3, ApoH, APOE, APOJ) except ApoH were higher in females than in males, although for ApoA2 this did not reach statistical significance. Levels of ApoH were not significantly different between males and females. |
Formal Description Interaction-ID: 74995 |
phenotype sex, female increases_quantity of gene/protein |
Drugbank entries | Show/Hide entries for APOH |
Comment | Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant. |
Formal Description Interaction-ID: 74996 |
phenotype sex, female affects_activity of process |
Comment | Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant. |
Formal Description Interaction-ID: 75002 |
phenotype sex, male NOT affects_activity of process |
Comment | Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant. |
Formal Description Interaction-ID: 75003 |
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Comment | Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant. |
Formal Description Interaction-ID: 75004 |
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Comment | Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant. |
Formal Description Interaction-ID: 75006 |
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Comment | Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant. |
Formal Description Interaction-ID: 75007 |
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Comment | Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant. |
Formal Description Interaction-ID: 75008 |
phenotype decreased level of APOA1 increases_activity of process |
Comment | Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant. |
Formal Description Interaction-ID: 75010 |
phenotype decreased level of APOA2 increases_activity of process |
Comment | Significant sex differences were observed for 56-86 year olds for ApoB, ApoE, and ApoH. Females had significant negative associations of ApoB, ApoE, ApoH, and ApoJ with cognition. The remaining 3 apolipoproteins (ApoA1, ApoA2, and ApoC3) showed similar trends in females approaching significance, whereas associations for males were nonsignificant. |
Formal Description Interaction-ID: 75011 |
phenotype decreased level of APOC3 increases_activity of process |