Schallreuter KU et al.(1994) Defective tetrahydrobiopterin and catecholamine biosynthesis in the depigmentation disorder vitiligo Biochim. Biophys. Acta 1226: 181-192
[PMID: 8204666]
Interaction Information:
Comment
Continuous production of 6-BH4 due to increased GTP-cyclohydrolase I activity in Vitiligo patients, leads to an accumulation of the non-enzymatic byproduct 7-tetrahydropterin in the epidermis and to an excess of norepinephrine in both the plasma and urine of these patients.
CIDeRplus