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Field	Query

	Field	Term

General Information:

Id:	7,552
Diseases:	Neurological
Organism:	Homo sapiens
Publication type:	article/cited
Reference:	Arnold AC et al.(2017) Hyperinsulinemia and Insulin Resistance in Dopamine beta-Hydroxylase Deficiency J. Clin. Endocrinol. Metab. 102: 10-14 [PMID: 27778639]

Interaction Information:

Comment	Dopamine beta-hydroxylase deficiency is a rare genetic disorder characterized by failure to convert dopamine to norepinephrine. (cited information)
Formal Description Interaction-ID: 74762	gene/protein DBH affects_activity of disease Dopamine beta-hydroxylase deficiency
Drugbank entries	Show/Hide entries for DBH
Drugbank DB00126	Vitamin C not specified DBH
Drugbank DB00822	Disulfiram inhibitor DBH
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00126	Vitamin C not specified DBH

Comment	Dopamine beta-hydroxylase deficiency is a rare genetic disorder characterized by failure to convert dopamine to norepinephrine (Noradrenaline). Due to the defect in the enzyme dopamine beta-hydroxylase levels of plasma norepinephrine and epinephrine are undetectable and dopamine levels are high. (cited information)
Formal Description Interaction-ID: 74763	gene/protein DBH increases_quantity of drug/chemical compound Noradrenaline
Drugbank entries	Show/Hide entries for DBH
Drugbank DB00126	Vitamin C not specified DBH
Drugbank DB00822	Disulfiram inhibitor DBH
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00126	Vitamin C not specified DBH

Comment	Dopamine beta-hydroxylase deficiency is a rare genetic disorder characterized by failure to convert dopamine to norepinephrine (Noradrenaline). Due to the defect in the enzyme dopamine beta-hydroxylase levels of plasma norepinephrine and epinephrine are undetectable and dopamine levels are high. (cited information)
Formal Description Interaction-ID: 74764	gene/protein DBH decreases_quantity of drug/chemical compound Dopamine
Drugbank entries	Show/Hide entries for DBH or Dopamine
Drugbank DB00126	Vitamin C not specified DBH
Drugbank DB00822	Disulfiram inhibitor DBH
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00126	Vitamin C not specified DBH
Drugbank DB00988	Dopamine agonist DRD1
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00988	Dopamine agonist DRD5
Drugbank DB00988	Dopamine agonist DRD2
Drugbank DB00988	Dopamine agonist DRD3
Drugbank DB00988	Dopamine agonist DRD4
Drugbank DB00988	Dopamine inducer SLC6A3

Comment	Dopamine beta-hydroxylase deficiency is a rare genetic disorder characterized by failure to convert dopamine to norepinephrine (Noradrenaline). (cited information)
Formal Description Interaction-ID: 74765	drug/chemical compound Dopamine increases_quantity of drug/chemical compound Noradrenaline
Drugbank entries	Show/Hide entries for Dopamine
Drugbank DB00988	Dopamine agonist DRD1
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00988	Dopamine agonist DRD5
Drugbank DB00988	Dopamine agonist DRD2
Drugbank DB00988	Dopamine agonist DRD3
Drugbank DB00988	Dopamine agonist DRD4
Drugbank DB00988	Dopamine inducer SLC6A3

Comment	In patients with dopamine beta-hydroxylase deficiency glucose-stimulated insulin secretion is enhanced.
Formal Description Interaction-ID: 74773	disease Dopamine beta-hydroxylase deficiency increases_activity of process insulin secretion

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