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Field	Query

	Field	Term

General Information:

Id:	7,548
Diseases:	Metabolic
Organism:	Mammalia
Publication type:	article
Reference:	[PMID: 14216443]

Interaction Information:

Comment	Tyrosine hydroxylase is inhibited by phenylalanine.
Formal Description Interaction-ID: 74699	drug/chemical compound Phenylalanine decreases_activity of gene/protein TH
Drugbank entries	Show/Hide entries for TH
Drugbank DB00120	L-Phenylalanine binder TH
Drugbank DB00135	L-Tyrosine binder TH
Drugbank DB00360	Tetrahydrobiopterin cofactor TH
Drugbank DB00765	Metyrosine binder TH
Drugbank DB03552	Meta-Tyrosine not specified TH
Drugbank DB04400	7,8-Dihydrobiopterin not specified TH
Drugbank DB00120	L-Phenylalanine binder TH
Drugbank DB00135	L-Tyrosine binder TH
Drugbank DB00765	Metyrosine binder TH
Drugbank DB03552	Meta-Tyrosine not specified TH
Drugbank DB04400	7,8-Dihydrobiopterin not specified TH

Comment	Tyrosine hydroxylase converts tyrosine into L-DOPA, which is further decarboxylated to dopamine.
Formal Description Interaction-ID: 74710	gene/protein TH increases_quantity of drug/chemical compound 3,4-Dihydroxy-L-phenylalanine
Drugbank entries	Show/Hide entries for TH
Drugbank DB00120	L-Phenylalanine binder TH
Drugbank DB00135	L-Tyrosine binder TH
Drugbank DB00360	Tetrahydrobiopterin cofactor TH
Drugbank DB00765	Metyrosine binder TH
Drugbank DB03552	Meta-Tyrosine not specified TH
Drugbank DB04400	7,8-Dihydrobiopterin not specified TH
Drugbank DB00120	L-Phenylalanine binder TH
Drugbank DB00135	L-Tyrosine binder TH
Drugbank DB00765	Metyrosine binder TH
Drugbank DB03552	Meta-Tyrosine not specified TH
Drugbank DB04400	7,8-Dihydrobiopterin not specified TH

Comment	Tyrosine hydroxylase converts tyrosine into L-DOPA, which is further decarboxylated to dopamine.
Formal Description Interaction-ID: 74711	gene/protein TH decreases_quantity of drug/chemical compound Tyrosine
Drugbank entries	Show/Hide entries for TH
Drugbank DB00120	L-Phenylalanine binder TH
Drugbank DB00135	L-Tyrosine binder TH
Drugbank DB00360	Tetrahydrobiopterin cofactor TH
Drugbank DB00765	Metyrosine binder TH
Drugbank DB03552	Meta-Tyrosine not specified TH
Drugbank DB04400	7,8-Dihydrobiopterin not specified TH
Drugbank DB00120	L-Phenylalanine binder TH
Drugbank DB00135	L-Tyrosine binder TH
Drugbank DB00765	Metyrosine binder TH
Drugbank DB03552	Meta-Tyrosine not specified TH
Drugbank DB04400	7,8-Dihydrobiopterin not specified TH

Comment	Tyrosine hydroxylase converts tyrosine into L-DOPA, which is further decarboxylated to dopamine.
Formal Description Interaction-ID: 74712	gene/protein DDC decreases_quantity of drug/chemical compound 3,4-Dihydroxy-L-phenylalanine
Drugbank entries	Show/Hide entries for DDC
Drugbank DB00114	Pyridoxal Phosphate cofactor DDC
Drugbank DB00114	Pyridoxal Phosphate cofactor DDC
Drugbank DB00114	Pyridoxal Phosphate cofactor DDC
Drugbank DB00190	Carbidopa inhibitor DDC
Drugbank DB00190	Carbidopa inhibitor DDC

Comment	Tyrosine hydroxylase converts tyrosine into L-DOPA, which is further decarboxylated to dopamine.
Formal Description Interaction-ID: 74713	gene/protein DDC increases_quantity of drug/chemical compound Dopamine
Drugbank entries	Show/Hide entries for DDC or Dopamine
Drugbank DB00114	Pyridoxal Phosphate cofactor DDC
Drugbank DB00114	Pyridoxal Phosphate cofactor DDC
Drugbank DB00114	Pyridoxal Phosphate cofactor DDC
Drugbank DB00190	Carbidopa inhibitor DDC
Drugbank DB00190	Carbidopa inhibitor DDC
Drugbank DB00988	Dopamine agonist DRD1
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00988	Dopamine agonist DRD5
Drugbank DB00988	Dopamine agonist DRD2
Drugbank DB00988	Dopamine agonist DRD3
Drugbank DB00988	Dopamine agonist DRD4
Drugbank DB00988	Dopamine inducer SLC6A3

Comment	Tyrosine hydroxylase converts tyrosine into L-DOPA, which is further decarboxylated to dopamine.
Formal Description Interaction-ID: 74714	drug/chemical compound 3,4-Dihydroxy-L-phenylalanine increases_quantity of drug/chemical compound Dopamine
Drugbank entries	Show/Hide entries for
Drugbank DB00988	Dopamine agonist DRD1
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00988	Dopamine agonist DRD5
Drugbank DB00988	Dopamine agonist DRD2
Drugbank DB00988	Dopamine agonist DRD3
Drugbank DB00988	Dopamine agonist DRD4
Drugbank DB00988	Dopamine inducer SLC6A3

Comment	Tyrosine hydroxylase converts tyrosine into L-DOPA, which is further decarboxylated to dopamine.
Formal Description Interaction-ID: 74715	drug/chemical compound Tyrosine increases_quantity of drug/chemical compound 3,4-Dihydroxy-L-phenylalanine

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