General Information:

Id: 7,542
Diseases: Metabolic
Phenylketonuria - [OMIM]
Homo sapiens
adults with phenylketonuria
article
Reference: Yano S et al.(2014) Melatonin and dopamine as biomarkers to optimize treatment in phenylketonuria: effects of tryptophan and tyrosine supplementation J. Pediatr. 165: 184-189 [PMID: 24857519]

Interaction Information:

Comment After supplementation of ten adult individuals with phenylketonuria with tryptophan, serum melatonin was not increased, but dopamine levels were increased.
Formal Description
Interaction-ID: 74601

drug/chemical compound

Tryptophan

NOT increases_quantity of

drug/chemical compound

Melatonin

in serum of PKU individuals
Drugbank entries Show/Hide entries for
Comment After supplementation of ten adult individuals with phenylketonuria with tryptophan, serum melatonin was not increased, but dopamine levels were increased.
Formal Description
Interaction-ID: 74602

drug/chemical compound

Tryptophan

increases_quantity of

drug/chemical compound

Dopamine

in serum of PKU individuals
Drugbank entries Show/Hide entries for
Comment High phenylalanine levels in patients with phenylketonuria suppresses serotonin synthesis. This might be due to suppression of tryptophan hydroxylase.
Formal Description
Interaction-ID: 74603

drug/chemical compound

Phenylalanine

decreases_quantity of

drug/chemical compound

Serotonin

Comment High phenylalanine levels in patients with phenylketonuria suppresses serotonin synthesis. This might be due to suppression of tryptophan hydroxylase.
Formal Description
Interaction-ID: 74863

disease

Phenylketonuria

decreases_quantity of

drug/chemical compound

Serotonin

due to high high Phe concentrations in PKU patients