CIDeRplusGeneral Information:
| Id: | 7,538 |
| Diseases: |
Metabolic
Phenylketonuria - [OMIM] |
| Mammalia | |
| article/cited | |
| Reference: | Yano S et al.(2016) Evaluation of Tetrahydrobiopterin Therapy with Large Neutral Amino Acid Supplementation in Phenylketonuria: Effects on Potential Peripheral Biomarkers, Melatonin and Dopamine, for Brain Monoamine Neurotransmitters PLoS ONE 11 [PMID: 27513937] |
Interaction Information:
| Comment | Individuals with Phenylketonuria develop significant intellectual disability due to high phenylalanine concentrations in the blood. (cited information) |
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Formal Description Interaction-ID: 74543 |
phenotype Hyperphenylalaninemia increases_activity of phenotype intellectual disability |
| Comment | Melatonin is synthesized from serotonin in the pinealocytes. For this reason the melatonin concentration in the blood reflects the concentration of serotonin in the brain. (cited information) |
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Formal Description Interaction-ID: 74600 |
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| Drugbank entries | Show/Hide entries for |
| Comment | Melatonin concentration in blood and urine (reflecting serotonin levels in brain) of individuals with PKU are low, due high blood Phe concentration. High level of phenylalanine leads to competitive inhibition of Trp transport via SLC7A5 (LAT1) and inhibition of Trp hydroxylase. (cited information) |
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Formal Description Interaction-ID: 74604 |
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| Comment | Serotonin concentration in blood and urine (reflecting serotonin levels in brain) of individuals with PKU are low, due high blood Phe concentration. High level of phenylalanine leads to competitive inhibition of Trp transport via SLC7A5 (LAT1) and inhibition of Trp hydroxylase. (cited information) |
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Formal Description Interaction-ID: 74605 |
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| Comment | After Tyr supplementation the dopamine level in urine increased. (cited information) |
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Formal Description Interaction-ID: 74609 |
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| Drugbank entries | Show/Hide entries for |
| Comment | Melatonin synthesis in patients with PKU increased after Trp supplementation (via LNAA supplementation providing Trp at 30 mg/kg/d). |
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Formal Description Interaction-ID: 74616 |
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| Drugbank entries | Show/Hide entries for |
| Comment | Serotonin concentration in blood and urine (reflecting serotonin levels in brain) of individuals with PKU are low, due high blood Phe concentration. High levels of phenylalanine lead to competitive inhibition of Trp transport via SLC7A5 (LAT1) and inhibition of Trp hydroxylase. (cited information) |
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Formal Description Interaction-ID: 74809 |
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| Comment | Individuals with Phenylketonuria develop significant intellectual disability due to high phenylalanine concentrations in the blood. (cited information) |
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Formal Description Interaction-ID: 75844 |
disease increases_activity of phenotype cognitive impairment |
| Comment | Melatonin concentration in blood and urine (reflecting serotonin levels in brain) of individuals with PKU are low, due high blood Phe concentration. High level of phenylalanine leads to competitive inhibition of Trp transport via SLC7A5 (LAT1) and inhibition of Trp hydroxylase. (cited information) |
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Formal Description Interaction-ID: 75845 |
disease decreases_quantity of drug/chemical compound |
| Comment | Melatonin concentration in blood and urine (reflecting serotonin levels in brain) of individuals with PKU are low, due high blood Phe concentration. High level of phenylalanine leads to competitive inhibition of Trp transport via SLC7A5 (LAT1) and inhibition of Trp hydroxylase. (cited information) |
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Formal Description Interaction-ID: 75849 |
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| Drugbank entries | Show/Hide entries for |
| Comment | Melatonin concentration in blood and urine (reflecting serotonin levels in brain) of individuals with PKU are low, due high blood Phe concentration. High level of phenylalanine leads to competitive inhibition of Trp transport via SLC7A5 (LAT1) and inhibition of Trp hydroxylase. (cited information) |
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Formal Description Interaction-ID: 75850 |
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| Drugbank entries | Show/Hide entries for |