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General Information:

Id:	7,536
Diseases:	Metabolic
Organism:	Mammalia
Publication type:	article/cited
Reference:	Fitzpatrick PF(2015) Structural insights into the regulation of aromatic amino acid hydroxylation Curr. Opin. Struct. Biol. 35: 1-6 [PMID: 26241318]

Interaction Information:

Comment	Phenylalanine hydroxylase in the liver catalyzes the hydroxylation of phenylalanine to form tyrosine. PAH deficiency is the cause for the autosomal recessive disease phenylketonuria. (cited information)
Formal Description Interaction-ID: 74532	gene/protein PAH decreases_quantity of drug/chemical compound Phenylalanine
Drugbank entries	Show/Hide entries for PAH
Drugbank DB00120	L-Phenylalanine not specified PAH
Drugbank DB00360	Tetrahydrobiopterin cofactor PAH
Drugbank DB00368	Norepinephrine inhibitor PAH
Drugbank DB00668	Epinephrine antagonist PAH
Drugbank DB02562	Quinonoid 7,8-Tetrahydrobiopterin not specified PAH
Drugbank DB02692	(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin not specified PAH
Drugbank DB02960	1-Carboxyethylaminomethyl-4-Aminomethylb ... not specified pah
Drugbank DB03673	Beta(2-Thienyl)Alanine not specified PAH
Drugbank DB04400	7,8-Dihydrobiopterin not specified PAH
Drugbank DB04419	Norleucine not specified PAH
Drugbank DB06262	Droxidopa inhibitor PAH
Drugbank DB00120	L-Phenylalanine not specified PAH
Drugbank DB02562	Quinonoid 7,8-Tetrahydrobiopterin not specified PAH
Drugbank DB02692	(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin not specified PAH
Drugbank DB02960	1-Carboxyethylaminomethyl-4-Aminomethylb ... not specified pah
Drugbank DB03673	Beta(2-Thienyl)Alanine not specified PAH
Drugbank DB04400	7,8-Dihydrobiopterin not specified PAH
Drugbank DB04419	Norleucine not specified PAH

Comment	Phenylalanine hydroxylase in the liver catalyzes the hydroxylation of phenylalanine to form tyrosine. PAH deficiency is the cause for the autosomal recessive disease phenylketonuria. (cited information)
Formal Description Interaction-ID: 74533	gene/protein PAH increases_quantity of drug/chemical compound Tyrosine
Drugbank entries	Show/Hide entries for PAH
Drugbank DB00120	L-Phenylalanine not specified PAH
Drugbank DB00360	Tetrahydrobiopterin cofactor PAH
Drugbank DB00368	Norepinephrine inhibitor PAH
Drugbank DB00668	Epinephrine antagonist PAH
Drugbank DB02562	Quinonoid 7,8-Tetrahydrobiopterin not specified PAH
Drugbank DB02692	(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin not specified PAH
Drugbank DB02960	1-Carboxyethylaminomethyl-4-Aminomethylb ... not specified pah
Drugbank DB03673	Beta(2-Thienyl)Alanine not specified PAH
Drugbank DB04400	7,8-Dihydrobiopterin not specified PAH
Drugbank DB04419	Norleucine not specified PAH
Drugbank DB06262	Droxidopa inhibitor PAH
Drugbank DB00120	L-Phenylalanine not specified PAH
Drugbank DB02562	Quinonoid 7,8-Tetrahydrobiopterin not specified PAH
Drugbank DB02692	(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin not specified PAH
Drugbank DB02960	1-Carboxyethylaminomethyl-4-Aminomethylb ... not specified pah
Drugbank DB03673	Beta(2-Thienyl)Alanine not specified PAH
Drugbank DB04400	7,8-Dihydrobiopterin not specified PAH
Drugbank DB04419	Norleucine not specified PAH

Comment	Tyrosine hydroxylase (TH) in the nervous system and the adrenal gland catalyzes the hydroxylation of tyrosine to form 3,4-dihydroxyphenylalanine. This is the key regulatory step in the biosynthesis of dopamine.
Formal Description Interaction-ID: 74534	gene/protein TH decreases_quantity of drug/chemical compound Tyrosine
Drugbank entries	Show/Hide entries for TH
Drugbank DB00120	L-Phenylalanine binder TH
Drugbank DB00135	L-Tyrosine binder TH
Drugbank DB00360	Tetrahydrobiopterin cofactor TH
Drugbank DB00765	Metyrosine binder TH
Drugbank DB03552	Meta-Tyrosine not specified TH
Drugbank DB04400	7,8-Dihydrobiopterin not specified TH
Drugbank DB00120	L-Phenylalanine binder TH
Drugbank DB00135	L-Tyrosine binder TH
Drugbank DB00765	Metyrosine binder TH
Drugbank DB03552	Meta-Tyrosine not specified TH
Drugbank DB04400	7,8-Dihydrobiopterin not specified TH

Comment	Tyrosine hydroxylase (TH) in the nervous system and the adrenal gland catalyzes the hydroxylation of tyrosine to form 3,4-dihydroxyphenylalanine. This is the key regulatory step in the biosynthesis of dopamine.
Formal Description Interaction-ID: 74535	gene/protein TH increases_quantity of drug/chemical compound Dopamine
Drugbank entries	Show/Hide entries for TH or Dopamine
Drugbank DB00120	L-Phenylalanine binder TH
Drugbank DB00135	L-Tyrosine binder TH
Drugbank DB00360	Tetrahydrobiopterin cofactor TH
Drugbank DB00765	Metyrosine binder TH
Drugbank DB03552	Meta-Tyrosine not specified TH
Drugbank DB04400	7,8-Dihydrobiopterin not specified TH
Drugbank DB00120	L-Phenylalanine binder TH
Drugbank DB00135	L-Tyrosine binder TH
Drugbank DB00765	Metyrosine binder TH
Drugbank DB03552	Meta-Tyrosine not specified TH
Drugbank DB04400	7,8-Dihydrobiopterin not specified TH
Drugbank DB00988	Dopamine agonist DRD1
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00988	Dopamine agonist DRD5
Drugbank DB00988	Dopamine agonist DRD2
Drugbank DB00988	Dopamine agonist DRD3
Drugbank DB00988	Dopamine agonist DRD4
Drugbank DB00988	Dopamine inducer SLC6A3

Comment	Phenylalanine hydroxylase in the liver catalyzes the hydroxylation of phenylalanine to form tyrosine. PAH deficiency is the cause for the autosomal recessive disease phenylketonuria. (cited information)
Formal Description Interaction-ID: 74536	drug/chemical compound Phenylalanine increases_quantity of drug/chemical compound Tyrosine

Comment	Tyrosine hydroxylase (TH) in the nervous system and the adrenal gland catalyzes the hydroxylation of tyrosine to form 3,4-dihydroxyphenylalanine. This is the key regulatory step in the biosynthesis of dopamine.
Formal Description Interaction-ID: 74537	drug/chemical compound Tyrosine increases_quantity of drug/chemical compound Dopamine
Drugbank entries	Show/Hide entries for
Drugbank DB00988	Dopamine agonist DRD1
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00988	Dopamine agonist DRD5
Drugbank DB00988	Dopamine agonist DRD2
Drugbank DB00988	Dopamine agonist DRD3
Drugbank DB00988	Dopamine agonist DRD4
Drugbank DB00988	Dopamine inducer SLC6A3

Comment	Tryptophan hydroxylase (TPH1 or TPH2) in the brain and gastric system catalyzes the hydroxylation of tryptophan to form 5-hydroxytryptophan during serotonin biosynthesis.
Formal Description Interaction-ID: 74538	gene/protein TPH1 decreases_quantity of drug/chemical compound Tryptophan
Drugbank entries	Show/Hide entries for TPH1
Drugbank DB00360	Tetrahydrobiopterin cofactor TPH1
Drugbank DB03271	7,8-Dihydro-L-Biopterin not specified TPH1
Drugbank DB03271	7,8-Dihydro-L-Biopterin not specified TPH1

Comment	Tryptophan hydroxylase (TPH1 or TPH2) in the brain and gastric system catalyzes the hydroxylation of tryptophan to form 5-hydroxytryptophan during serotonin biosynthesis.
Formal Description Interaction-ID: 74539	gene/protein TPH1 increases_quantity of drug/chemical compound 5-Hydroxytryptophan
Drugbank entries	Show/Hide entries for TPH1
Drugbank DB00360	Tetrahydrobiopterin cofactor TPH1
Drugbank DB03271	7,8-Dihydro-L-Biopterin not specified TPH1
Drugbank DB03271	7,8-Dihydro-L-Biopterin not specified TPH1

Comment	Tryptophan hydroxylase (TPH1 or TPH2) in the brain and gastric system catalyzes the hydroxylation of tryptophan to form 5-hydroxytryptophan during serotonin biosynthesis.
Formal Description Interaction-ID: 74540	drug/chemical compound Tryptophan increases_quantity of drug/chemical compound 5-Hydroxytryptophan

Comment	Tryptophan hydroxylase (TPH1 or TPH2) in the brain and gastric system catalyzes the hydroxylation of tryptophan to form 5-hydroxytryptophan during serotonin biosynthesis.
Formal Description Interaction-ID: 74541	drug/chemical compound 5-Hydroxytryptophan increases_quantity of drug/chemical compound Serotonin

Comment	Tryptophan hydroxylase (TPH1 or TPH2) in the brain and gastric system catalyzes the hydroxylation of tryptophan to form 5-hydroxytryptophan during serotonin biosynthesis.
Formal Description Interaction-ID: 74606	gene/protein TPH decreases_quantity of drug/chemical compound Tryptophan

Comment	Tryptophan hydroxylase (TPH1 or TPH2) in the brain and gastric system catalyzes the hydroxylation of tryptophan to form 5-hydroxytryptophan during serotonin biosynthesis.
Formal Description Interaction-ID: 74607	gene/protein TPH increases_quantity of drug/chemical compound 5-Hydroxytryptophan