General Information:

Id: 7,531 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
review
Reference: Muller TD et al.(2017) The New Biology and Pharmacology of Glucagon Physiol. Rev. 97: 721-766 [PMID: 28275047]

Interaction Information:

Comment Several lines of evidence indicate that glucagon enhances metabolic rate through activation of brown adipose tissue (BAT). Oxygen consumption and BAT temperature increase in rats following glucagon administration, and glucagon stimulates oxygen consumption in BAT-derived cells. Plasma levels of glucagon increase in rats and humans upon cold exposure, and cold-acclimatized rats have increased levels of glucagon in both plasma and BAT. Administration of norepinephrine increases BAT glucagon levels, and pretreatment of rats or hamsters with the beta-adrenergic receptor blocker propranolol blocks glucagon’s thermogenic effect.
Formal Description
Interaction-ID: 75376

drug/chemical compound

Noradrenaline

increases_quantity of

gene/protein

Glucagon

in brown adipose tissue