CIDeRplusGeneral Information:
| Id: | 7,531 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Homo sapiens | |
| review | |
| Reference: | Muller TD et al.(2017) The New Biology and Pharmacology of Glucagon Physiol. Rev. 97: 721-766 [PMID: 28275047] |
Interaction Information:
| Comment | The machinery regulating the secretion of somatostatin (SST) from the delta-cells is similar to those regulating the secretion of insulin and glucagon. Accordingly, the delta-cells express K-ATP channels that when blocked generate a membrane potential that entails opening of VDCC. The resulting Ca2+ influx subsequently stimulates fusion of the SST granules with the plasma membrane and secretion of SST into the circulation. In contrast, opening of K-ATP channels using, e.g., diazoxide, renders a membrane potential that entails closing of VDCC, decrease of Ca2+ influx, and thus inhibition of SST secretion. The secretion of SST from delta-cells is stimulated by glucose, amino acids, and GLP-1, while norepinephrine and insulin inhibit its release. |
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Formal Description Interaction-ID: 75236 |
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