CIDeRplusGeneral Information:
| Id: | 7,527 (click here to show other Interactions for entry) |
| Diseases: |
Cardiovascular disease
Diabetes mellitus, type II - [OMIM] Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Kjolby M et al.(2015) Sortilin, encoded by the cardiovascular risk gene SORT1, and its suggested functions in cardiovascular disease Curr Atheroscler Rep 17: 496 [PMID: 25702058] |
Interaction Information:
| Comment | SORT1 encodes sortilin, a multiligand type 1 receptor that is expressed in many cell and tissue types including brain, heart, bone, fat, liver and neurons, hepatocytes, adipocytes, smooth muscle cells, blood lymphocytes, and macrophages. The extracellular part of sortilin is dominated by a small N-terminal propeptide followed by a large ligand binding 10-bladed beta-propeller. The propeptide prevents ligands from interacting with (pro)sortilin in the biosynthetic pathway until it is removed by cleavage in or after passage of the trans-Golgi network (TGN). The mature receptor binds a variety of ligands encompassing nerve growth factors and peptides, as well as cytokines and ligands associatedwith lipid metabolism, e.g., lipoprotein lipase, APOA-V, DLK1 and has, accordingly, been implicated in alternate tissue dependent functions. Sortilin is expressed on the cell surface in low abundance but predominates in Golgi and paranuclear compartments, and its short cytoplasmic domain contains functional motifs for endocytosis as well as Golgi-endosome sorting. |
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Formal Description Interaction-ID: 74357 |
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